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Investigate into the relationship between RELN gene single nucleotide polymorphism and childhood autism〖WT5"BX〗SUN Ying,SHENG Zhaoming,JIANG Zhimei,et al.Division of Pediatric Neurology,the Third Affiliated Hospital of Jiamusi University,Jiamusi 154003,China
2010, 2 (6):
496-498.
doi: 10.3969/j.issn.16743865.2010.06.007
ObjectiveTo investigate the relationship between RELN gene single nucleotide polymorphism and childhood autism in Han population in Jiamusi.MethodsPolymerase chain reactionrestricted fragment length polymorphism(PCRRFLP)was used to determine allele and genotype of SNP(exon 6)of RELN in Chinese Han autism children staying in the 3rd Affiliated Hospital of Jiamusi University and 30 normal children in a kindergarten and an elementary school in Jiamusi from January,2006 to December,2007.Results(1)There was a significant difference in the distribution of the allelic frequencies and genotype in exon 6 between the two groups(P<0.05).(2)There was no significant difference in the distribution of the allelic frequencies and genotype in Exon 50 between the two groups(P>0.05).Conclusions(1)There is an association between the SNP(exon 6) of RELN and childhood autism.(2)There is no association between the SNP(Exon 50)of RELN and childhood autism.
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