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25 October 2010, Volume 2 Issue 5 Previous Issue    Next Issue

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Research of TCM clinical validation scheme on children′s pneumonia with“wind and heat blocking the lung syndrome”and“phlegmheat obstructing the lung syndrome”by multicenter randomized controlled study Lining,WANG Xuefeng,YUAN Xiaofeng，et al 2010, 2 (5):  386-391.  doi: 10.3969/j.issn.1674-3865.2010.05.002 Abstract ( 399 )   PDF (624KB) ( 144 )   Save ObjectiveTo evaluate the effect superiority of TCM on children′s pneumonia with“wind and heat blocking the lung syndrome”and“phlegmheatobstructingthelung syndrome”objectively. MethodsMulticenter,randomized controlled study was done on 640 cases of pneumonia with“wind and heat blocking the lung syndrome”and“phlegmheat obstructing the lung syndrome”in thirteen hospitals by TCM clinical validation scheme.Children with pneumonia were randomly divided into 3 groups.Besides the basic treatment of Chinese patent drug by intravenous injections,children in group A were treated with TCM decoction according to syndrome;in group B,the patients were treated by external application of Fubei plaster,while the children in group C were treated by internal administration and external application of Fubei plaster.The course of therapy was 14 days for each group.The children′s clinical symptoms were recorded at the 1,7,14 days of admission.To all these groups,the general effect and syndrome score of TCM were analyzed. ResultsIn these three groups,the score of clinical symptoms obviously decreased after treatment,indicateding that three therapies all let patients′ condition ameliorate,and the clinical outcome time corresponds with course of children′s pneumonia.On the 7th day,in group C,the score diminishing rates were better than the other groups (P<0.05),especially in the group of“wind and heat blocking the lung syndrome”.The score diminishing rates in the group of“phlegmheat obstructing the lung syndrome”and on 14th day were of no differences among the three groups (P>0.05).There was no difference among the three groups on the symptom in fever,sputum,cough,breathlessness and auscultation on the lung recovered (P>0.05).On the 7th day, the effective rates were 59.9% in group A, 56.69% in group B and 70.2% in group C respectively.There was significant difference among the three groups (P<0.05), which meant clinical effect of group C was superior than the other groups. At the same points for the “wind and heat blocking the lung syndrome”,the effective rates were 58.1% in group A,54.8% in group B and 74.0% in group C respectively.There was significant difference among the three groups (P<0.05);and for the“phlegmheat obstructing the lung syndrome”on the 14th day,there was no significant difference among the three groups (P>0.05). ConclusionsTCM has marked clinical effect on children′s pneumonia,whether by internal administration of Chinese recipe prescribed according to syndrome differentiation,external application of Fubei plaster,or combining both methods,especially in the early stage of pneumonia.Besides,application therapy is more handy simpler and more convenient,so we could popularize this method. Related Articles | Metrics

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Astragalus membranaceus Injection(AMI)in children′s viral myocarditis (VMC): a systematic review HU Siyuan，MA Rong，XU Qiang 2010, 2 (5):  411-416.  doi: 10.3969/j.issn.1674-3865.2010.05.012 Abstract ( 314 )   PDF (1745KB) ( 94 )   Save ObjectiveTo evaluate the effect and safety of Astragalus membranaceus Injection（AMI） combined with convetional western medicine in treating children′s viral myocarditis（VMC）. MethodsWe formulated the inclusion criteria, exclusion criteria and retrieval strategy on the basis of original literatures, searched Cochrane central Register of Controlled Trials,PUBMED,CNKI,VIP.Randomized controlled trials (RCTs) of routin treatment (RT) with AMI compared with RT only in treating children′s VMC and eligible studies were included;the methodological quality of inclusive trials was assessed by Jadad scale of Cochrane Collaboration recommended. Metaanalysis was used to analyse the data by statistical software RevMan4.2.10. We adopted clinical effective rate, EKG, myocardial enzymes, cardiac function and adverse reaction rate as observation indexs, made qualitative and quantitative analysis. ResultsWe found 291 literatures totally. Among these literatures, 22 RCTs(934/847)were selected. All RCTs were low methodological quality according to Jadad score index. Metaanalysis indicated that RR and 95% CIof 21 RCTs′s(894/807)effective rate was 4.53［3.33， 6.17］.WMD and 95% CIof 7 RCTs′s(342/322)improving CKMB and 1 RCT′s (44/39)improving EF were -10.19［-14.02， -6.36］ and 2.30［-3.22， 7.82］ respectively. RR and 95% CI of7 RCTs′s(302/264)EKG improvement rate was 4.62［2.72， 7.84］. This systematic review showed that AMI was effective and safe for children′s VMC. In view of effective rate, EKG improvement rate and improving CKMB, there were great difference between two groups (P<0.00001). ConclusionsAMI is effective and safe for children′s VMC;it can improve clinical effect rate and EKG improvement rate, decrease CKMB in blood for.However, the evidence is not strong because of low methodological quality of these literatures. To further evaluate the effect and safety of AMI for children′s VMC more rationally designed and strictly executed RCTs with large samples need to be made Related Articles | Metrics