基于文献研究的中国孤独症儿童肠道菌群特征分析

doi:10.20274/j.cnki.issn.2025.04.006

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (4): 302-312.doi: 10.20274/j.cnki.issn.2025.04.006

基于文献研究的中国孤独症儿童肠道菌群特征分析

易惺钱^1,², 黄敬滢¹, 熊智燚¹, 陈晓凡¹, 刘英^1,², 李小艳², 王立³()

330006 南昌，江西中医药大学临床医学院中医儿科教研室（易惺钱，刘英）
江西中医药大学中医儿科学专业研究生（黄敬滢，熊智燚）
江西中医药大学中医学院（陈晓凡）
330004 南昌，江西中医药大学附属医院儿科（易惺钱，刘英，李小艳）
330036 南昌，南昌医学院（王立）

收稿日期:2024-12-28 修回日期:2025-04-20 出版日期:2025-08-25 上线日期:2025-08-25
通讯作者: 王立 E-mail:353613747@qq.com
作者简介:易惺钱（1986-），女，医学博士，副教授。研究方向：针刺推拿防治儿童神经行为障碍性疾病机制研究
基金资助:
江西省教育厅科学技术研究项目(GJJ2403625);江西省中医药管理局科技计划项目(2023A0034);江西省双高人才项目(12623009);2022年度江西省（省直单位）名老中医药专家学术经验继承工作项目(赣财社指〔2022〕81号)

Analysis of intestinal microbiome characteristics of children with autism in China based on literature research

Xingqian YI^1,², Jing Ying NG¹, Zhiyi XIONG¹, Xiaofan CHEN¹, Ying LIU^1,², Xiaoyan LI², Li WANG³()

^1.Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China
^2.The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
^3.Nanchang Medical College, Nanchang 330036, China

Received:2024-12-28 Revised:2025-04-20 Published:2025-08-25 Online:2025-08-25
Contact: Li WANG E-mail:353613747@qq.com
Supported by:
Scientific and Technological Research Project of Jiangxi Provincial Department of Education(GJJ2403625)

摘要/Abstract

摘要：

目的基于现有文献证据综述孤独症谱系障碍(ASD)患儿肠道菌群特征，探讨其与ASD核心症状的相关性，以期为肠道微生物疗法干预ASD提供理论依据。方法系统检索万方、知网、维普、Web of Science等相关数据库有关中国地区ASD患儿肠道菌群特征相关的文献，检索时限截止至2024年1月6日，按照纳入和排除标准筛选合格文献，提取资料，采用纽卡斯尔-渥太华病例对照研究量表（NOS)对纳入文献进行质量评价。结果共纳入文献33篇，研究对象为2～14岁的ASD患儿，共2 042例。16项研究分析了ASD患儿与健康儿童肠道菌群α或β的多样性，其中7篇报道了α和β的多样性，5篇仅描述α多样性，另4篇仅提及β多样性，但结果不一致。在门水平上，厚壁菌门报道次数最多，9篇文献提及其丰度与ASD有关，其次是拟杆菌门和变形菌门分别在7篇文献中提及。ASD的严重程度与巨单胞菌属、巨球菌属、埃希氏菌属、链球菌属、双歧杆菌属和巴恩斯氏菌相关，社交行为与巨单胞菌属、拟杆菌属、梭状芽孢杆菌属、萨特氏菌属、乳酸杆菌属、布劳特氏菌、链球菌和双歧杆菌相关，而语言障碍与巨单胞菌属有关，认知发育与双歧杆菌属、链球菌属、布劳特氏菌属和拟杆菌属关系密切，刻板行为与梭状芽孢杆菌属、乳酸杆菌属和双歧杆菌相关，情绪障碍则与双歧杆菌有关,胃肠症状如便秘等与厚壁菌门、拟杆菌门和拟杆菌属的丰度密切相关。结论 ASD患儿与健康儿童肠道菌群存在明显差异，参与ASD核心及伴随症状的肠道菌群较多，且大部分与ASD相关的菌群隶属于厚壁菌门，可见厚壁菌门的丰度与ASD的发生发展密切相关。

关键词: 孤独症谱系障碍, 肠道菌群, 系统综述, 中国儿童

Abstract:

Objective To review the characteristics of intestinal microbiome in children with autism spectrum disorder (ASD) based on existing literature evidence, and to explore their correlation with core symptoms of ASD, in order to provide theoretical basis for intestinal microbiome intervention in ASD. Methods The literature on intestinal microbiome characteristics of children with ASD in China was systematically searched for in Wanfang, China national knowledge infrastructure (CNKI), Weipu database (VIP), Web of Science and other relevant databases until January 6, 2024. Qualified articles were selected according to inclusion and exclusion criteria, data were extracted, and the quality of the included articles was evaluated using the Newcastle and Ottawa scale (NOS). Results A total of 33 articles were included, and the study subjects were 2 042 children with ASD aged 2 to 14 years.In 16 studies α or β diversity in the intestinal microbiome was analyzed in the children with ASD and healthy children, of which seven reported α and β diversity, five described only α diversity, and four mentioned only β diversity, but the results were inconsistent.At the phylum level,Firmicutes were the most frequently reported, with 9 articles mentioning that their abundance was related to ASD, followed by Bacteroidetes and Proteobacteria, each mentioned in 7 articles. Megamonas, Megasphaera, Barnesiella, Escherichia, Streptococcus and Bifidobacterium were associated with the severity of ASD. Megamonas, Blautia, Streptococcus, Bacteroides, Clostridium, Sutterella, Lactobacillus and Bifidobacterium were reported to be associated with social behavior, while Megamonas was associated with speech disorders. Bifidobacterium, Streptococcus, Blautia and Bacteroides were associated with cognitive development. Clostridium, Lactobacillus and Bifidobacterium were associated with stereotypical behavior, while Bifidobacterium was associated with mood disorders. The abundance of Firmicutes, Bacteroidetes and Bacteroides was associated with gastrointestinal symptoms such as constipation. Conclusion There are significant differences in intestinal microbiome between children with ASD and healthy children. There is a great number of intestinal microbiome involved in the core and accompanying symptoms of ASD, and most of the microbiome associated with ASD belong to phylum Firmicutes, indicating that the abundance of Firmicutes is closely related to the occurrence and development of ASD.

Key words: Autism spectrum disorder, Intestinal microbiome, Systematic review, Chinese children

中图分类号:

R277.7

易惺钱, 黄敬滢, 熊智燚, 陈晓凡, 刘英, 李小艳, 王立. 基于文献研究的中国孤独症儿童肠道菌群特征分析[J]. 中国中西医结合儿科学, 2025, 17(4): 302-312.

Xingqian YI, Jing Ying NG, Zhiyi XIONG, Xiaofan CHEN, Ying LIU, Xiaoyan LI, Li WANG. Analysis of intestinal microbiome characteristics of children with autism in China based on literature research[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 302-312.

图/表 4

参考文献 93

[1]	Robertson RC, Manges AR, Brett Finlay B, et al. The human microbiome and child growth - first 1000 days and beyond[J]. Trends Microbiol, 2019, 27(2): 131-147.
[2]	赵亚楠, 李智文, 李琳, 等. 中国0～6岁儿童孤独症谱系障碍筛查患病现状[J]. 中国生育健康杂志, 2023, 34(5): 423-428.
[3]	徐玉兵, 刘兴晖, 张蜀豫, 等. 儿童孤独症谱系障碍患者的母亲肠道菌群组成特征及其对疾病预测价值的研究[J]. 现代检验医学杂志, 2022, 37(5): 65-69.
[4]	周自云. 孤独症谱系障碍儿童饮食行为问题及肠道微生物的研究[D]. 合肥: 安徽医科大学, 2015.
[5]	杨娇, 廖章伊, 任锦丽, 等. 环境对自闭症影响的研究进展[J]. 中国生育健康杂志, 2019, 30(2): 183-185.
[6]	马佳, 彭献, 何樨. ASD患儿肠道菌群失衡、免疫指标紊乱调查及关系分析[J]. 医学食疗与健康, 2022, 20(1): 81-83, 93.
[7]	徐宇明, 姚宝珍. 剖宫产与常见儿童神经发育障碍相关性新进展[J]. 武汉大学学报(医学版), 2023, 44(9): 1148-1153.
[8]	赵晴, 刘星吟. 肠道微生物在孤独症中的研究进展[J]. 中国科学: 生命科学, 2023, 53(5): 605-615.
[9]	王芳, 杨广学, 郭德华. 自闭症谱系障碍成因的菌肠脑轴模型研究新进展[J]. 中国康复医学杂志, 2018, 33(5): 598-603.
[10]	Wells GA, Wells G, Shea B, et al. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in Meta-analyses[EB/OL].[2024-12-18]. .
[11]	李德欣, 陈强, 庄志成, 等. 孤独症谱系障碍儿童肠道菌群与症状严重程度相关性研究[J]. 中国儿童保健杂志, 2023, 31(5): 497-501.
[12]	李正, 肖贵元, 罗雅婷, 等. 孤独症谱系障碍儿童血清叶酸、维生素B₁₂水平与肠道菌群的关联[J]. 中国儿童保健杂志, 2023, 31(3): 246-251.
[13]	Ma B, Liang J, Dai M, et al. Altered gut microbiota in Chinese children with autism spectrum disorders[J]. Front Cell Infect Microbiol, 2019, 9: 40.
[14]	刘丽艳, 杨丽, 秦国涛, 等. 粪菌移植干预在治疗儿童自闭症中的疗效分析[J]. 中国病原生物学杂志, 2024, 19(1): 83-87.
[15]	Wang M, Wan J, Rong H, et al. Alterations in gut glutamate metabolism associated with changes in gut microbiota composition in children with autism spectrum disorder[J]. mSystems, 2019, 4(1): e00321-18.
[16]	成霞, 袁伯稳. 自闭症患儿肠道菌群变化及其与自闭症分级的关系[J]. 中国微生态学杂志, 2021, 33(5): 560-563.
[17]	曾津, 危松青, 王曼知. 孤独症谱系障碍患儿肠道菌群与症状严重程度相关性分析[J]. 精神医学杂志, 2020, 33(1): 62-65.
[18]	刘智程. 孤独症谱系障碍儿童肠道菌群的结构及功能研究[D]. 合肥: 安徽医科大学, 2023.
[19]	张瑜. 自闭症儿童粪便肠道菌群、短链脂肪酸及血清标志物变化意义研究[D]. 镇江: 江苏大学, 2022.
[20]	张静, 王凯旋, 盛放, 等. 孤独症谱系障碍儿童肠道菌群多样性与Treg-Th17的相关性研究[J]. 中华全科医学, 2020, 18(8): 1324-1326.
[21]	吴薇岚, 江蕙芸, 陈雪, 等. 孤独症谱系障碍儿童肠道菌群多样性的研究[J]. 中国儿童保健杂志, 2020, 28(9): 980-984.
[22]	李正, 杨桂存, 蒋静, 等. 肠道菌群与孤独症谱系障碍儿童功能性便秘的关系[J]. 中国微生态学杂志, 2023, 35(1): 63-68.
[23]	张子同. 孤独症谱系障碍患儿肠道菌群构成研究[D]. 合肥: 安徽医科大学, 2023.
[24]	王军梅, 吴敏娜, 杨健全. 孤独症谱系障碍患儿肠道菌群的变化及意义[J]. 妇儿健康导刊, 2023(11): 49-51.
[25]	韩俊林, 林玉梅, 林堃, 等. 孤独症谱系障碍儿童的肠道菌群特点及其对患儿行为的影响[J]. 中外医学研究, 2023, 21(34): 63-67.
[26]	邹俊, 曾令兵, 蔡沁明, 等. 自闭症患者治疗前后肠道微生物菌群分布多样性研究[J]. 江西医药, 2019, 54(10): 1157-1160.
[27]	唐栋. 自闭症患儿肠道症状及菌群与行为的相关性[J]. 新疆医学, 2020, 50(11): 1158-1161.
[28]	曾佩佩, 曾婷, 邓梁琼, 等. 基于高通量测序分析孤独症谱系障碍儿童肠道菌群的构成变化[J]. 检验医学, 2021, 36(2): 153-161.
[29]	向彩虹. ASD儿童维生素A营养状况与肠道菌群结构的相关性研究[D]. 长沙: 中南大学, 2022.
[30]	丁雪. 肠道菌群与孤独症谱系障碍的相关性研究[D]. 郑州: 郑州大学, 2020.
[31]	刘思濛. 酪酸梭菌改善自闭症谱系障碍小鼠肠道屏障功能和行为症状的机制研究[D]. 郑州: 郑州大学, 2019.
[32]	陈换利. 孤独症谱系障碍儿童的肠道菌群特点及其与行为的相关性分析[D]. 济南: 山东大学, 2021.
[33]	刘欢. 复合益生菌干预对孤独症谱系障碍儿童症状、肠道菌群及其代谢产物的影响研究[D]. 镇江: 江苏大学, 2023.
[34]	谭雪莹. 孤独症谱系障碍儿童饮食行为及肠道菌群的探讨[D]. 湛江：广东医科大学,2021.
[35]	李宁. 孤独症谱系障碍儿童母子肠道菌群相关性及潜在风险评估标志物研究[D]. 济南: 山东大学, 2019.
[36]	张一然. 孤独症儿童心肝火旺证和心脾两虚证肠道菌群初步探究[D]. 咸阳: 陕西中医药大学, 2021.
[37]	Zou R, Xu F, Wang Y, et al. Changes in the gut microbiota of children with autism spectrum disorder[J]. Autism Res, 2020, 13(9): 1614-1625.
[38]	Niu M, Li Q, Zhang J, et al. Characterization of intestinal microbiota and probiotics treatment in children with autism spectrum disorders in China[J]. Front Neurol, 2019, 10: 1084.
[39]	Sun H, You Z, Jia L, et al. Autism spectrum disorder is associated with gut microbiota disorder in children[J]. BMC Pediatr, 2019, 19(1): 516.
[40]	Zhang M, Ma W, Zhang J, et al. Analysis of gut microbiota profiles and microbe-disease associations in children with autism spectrum disorders in China[J]. Sci Rep, 2018, 8(1): 13981.
[41]	Huang M, Liu K, Wei Z, et al. Serum oxytocin level correlates with gut microbiome dysbiosis in children with autism spectrum disorder[J]. Front Neurosci, 2021, 15: 721884.
[42]	Wong OWH, Lam AMW, Or BPN, et al. Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case-control study on prepubertal Chinese boys[J]. Sci Rep, 2022, 12(1): 10659.
[43]	Lyon L. 'All disease begins in the gut': was Hippocrates right[J]? Brain, 2018, 141(3): e20.
[44]	Chidambaram SB, Essa MM, Rathipriya AG, et al. Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: tales of a vicious cycle[J]. Pharmacol Ther, 2022, 231: 107988.
[45]	Agirman G, Yu KB, Hsiao EY. Signaling inflammation across the gut-brain axis[J]. Science, 2021, 374(6571): 1087-1092.
[46]	Cussotto S, Sandhu KV, Dinan TG, et al. The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective[J]. Front Neuroendocrinol, 2018, 51: 80-101.
[47]	Shin NR, Whon TW, Bae JW. Proteobacteria: microbial signature of dysbiosis in gut microbiota[J]. Trends Biotechnol, 2015, 33(9): 496-503.
[48]	曹瑞华, 张黎梦, 肖再利. 胃肠道5-羟色胺在炎症性肠病中的潜在生理作用[J]. 饲料博览, 2020(2): 41-47.
[49]	Lee A, Choo H, Jeon B. Serotonin receptors as therapeutic targets for autism spectrum disorder treatment[J]. Int J Mol Sci, 2022, 23(12): 6515.
[50]	Lesch KP, Waider J. Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders[J]. Neuron, 2012, 76(1): 175-191.
[51]	Mudd AT, Berding K, Wang M, et al. Serum Cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig[J]. Gut Microbes, 2017, 8(6): 589-600.
[52]	郭莉莉,胡建. 催产素在精神障碍治疗中的研究进展[J]. 中华行为医学与脑科学杂志,2014,23(10):956-958.
[53]	杜琳. 维生素D介导的Th17/Treg细胞稳态调节对孤独症大鼠肠道菌群失调作用的研究[D]. 长春: 吉林大学, 2019.
[54]	Luu M, Pautz S, Kohl V, et al. The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes[J]. Nat Commun, 2019, 10(1): 760.
[55]	刘智程, 吴德, 屈爱娜, 等. 孤独症谱系障碍儿童肠道菌群多样性研究及功能预测分析[J]. 中国当代儿科杂志, 2022, 24(12): 1356-1364.
[56]	Wan L, Wang H, Liang Y, et al. Effect of oral faecal microbiota transplantation intervention for children with autism spectrum disorder: a randomised, double-blind, placebo-controlled trial[J]. Clin Transl Med, 2024, 14(9): e70006.
[57]	刘思濛, 席华媛, 孙向东, 等. 孤独症谱系障碍小鼠肠道屏障功能研究[J]. 中国微生态学杂志, 2023, 35(1): 8-15.
[58]	刘欣, 郭宇冰, 楚治良, 等. 肠道菌群的影响因素研究进展[J]. 结直肠肛门外科, 2020, 26(4): 393-397.
[59]	李烨, 王晓艺, 刘星吟. 微生物药物在神经系统疾病中的研究进展[J]. 生命科学, 2023, 35(3): 296-306.
[60]	李可敏,李景南. 应激与肠道微生态-肠脑轴相互作用机制研究进展[J]. 中华内科杂志,2020,59(3):247-249.
[61]	Wolff JJ, Swanson MR, Elison JT, et al. Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism[J]. Mol Autism, 2017, 8: 8.
[62]	Ameis SH, Catani M. Altered white matter connectivity as a neural substrate for social impairment in Autism Spectrum Disorder[J]. Cortex, 2015, 62: 158-181.
[63]	马烨, 谭李红, 黄瑞文, 等. 早产儿神经发育与肠道菌群关系的初步研究[J]. 中国医师杂志, 2023, 25(7): 998-1002.
[64]	史延昊, 张宁, 黄俊伟, 等. 益生菌对高脂饮食诱导的遗忘型轻度认知障碍大鼠记忆力和肠道菌群的影响[J]. 现代中西医结合杂志, 2023, 32(4): 477-482.
[65]	赵锐豪, 郑鹏远, 刘思濛, 等. 孤独症谱系障碍儿童肠道菌群与行为症状的相关研究[J]. 中国当代儿科杂志, 2019, 21(7): 663-669.
[66]	MacFabe DF, Cain DP, Rodriguez-Capote K, et al. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders[J]. Behav Brain Res, 2007, 176(1): 149-169.
[67]	Al-Asmakh M, Anuar F, Zadjali F, et al. Gut microbial communities modulating brain development and function[J]. Gut Microbes, 2012, 3(4): 366-373.
[68]	Bermudez-Martin P, Becker JAJ, Caramello N, et al. The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota[J]. Microbiome, 2021, 9(1): 157.
[69]	Richdale AL, Schreck KA. Sleep problems in autism spectrum disorders: prevalence, nature, & possible biopsychosocial aetiologies[J]. Sleep Med Rev, 2009, 13(6): 403-411.
[70]	罗靓尹, 曹牧青, 石碧君, 等. 孤独症谱系障碍男童皮质醇分泌水平及其相关因素研究[J]. 教育生物学杂志, 2020, 8(1): 18-22.
[71]	谢巧珍. 头发中皮质醇的质谱检测及其与孤独症儿童行为的关联[D]. 南京:东南大学,2011.
[72]	赵婷. 3岁儿童肠道菌群分布与神经发育表型的关联分析[D]. 青岛: 青岛大学, 2019.
[73]	Kim KS. Escherichia coli translocation at the blood-brain barrier[J]. Infect Immun, 2001, 69(9): 5217-5222.
[74]	Lieblein-Boff JC, McKim DB, Shea DT, et al. Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron[J]. J Neurosci, 2013, 33(41): 16334-16345.
[75]	Billeci L, Calderoni S, Tosetti M, et al. White matter connectivity in children with autism spectrum disorders: a tract-based spatial statistics study[J]. BMC Neurol, 2012, 12: 148.
[76]	乐涛, 卢红艳, 薛正阳, 等. 基于高通量测序分析早产认知障碍大鼠肠道菌群结构特征[J]. 中国当代儿科杂志, 2019, 21(7): 701-707.
[77]	Liu J, Liu X, Xiong XQ, et al. Effect of vitamin A supplementation on gut microbiota in children with autism spectrum disorders - a pilot study[J]. BMC Microbiol, 2017, 17(1): 204.
[78]	白琦琦. 复合益生菌对ASD大鼠行为症状及肠道功能的影响[D]. 沈阳: 辽宁大学, 2023.
[79]	苗壮壮. 乳双歧杆菌Probio-M8对自闭症模型小鼠行为、肠道菌群及其代谢物质的影响[D]. 呼和浩特: 内蒙古农业大学, 2022.
[80]	刘娟. 维生素A对孤独症谱系障碍儿童肠道症状、肠道菌群与行为的影响[D]. 重庆: 重庆医科大学, 2018.
[81]	高紫琳, 许幼仕, 曾坤山, 等. 孤独症谱系障碍儿童肠道菌群与症状严重程度的相关性分析[J]. 中国当代医药, 2022, 29(34): 66-69.
[82]	Kelly JR, Minuto C, Cryan JF, et al. Cross talk: the microbiota and neurodevelopmental disorders[J]. Front Neurosci, 2017, 11: 490.
[83]	朱江. 维生素A对孤独症谱系障碍儿童肠道色氨酸代谢及症状的影响[D]. 重庆:重庆医科大学,2020.
[84]	Kedishvili NY. Enzymology of retinoic acid biosynthesis and degradation[J]. J Lipid Res, 2013, 54(7): 1744-1760.
[85]	孔文成, 李幼生. 维生素D在肠道中生理作用的研究进展[J]. 医学研究生学报, 2015, 28(1): 106-109.
[86]	秦莹, 仰曙芬. 维生素D与脑发育相关研究进展[J]. 中国儿童保健杂志, 2021, 29(4): 393-396.
[87]	张静, 王凯旋, 盛放, 等. 维生素D对孤独症谱系障碍儿童血清25(OH)D水平肠道症状及肠道菌群失调的影响[J]. 中国妇幼保健, 2020, 35(23): 4493-4495.
[88]	段云峰, 蔡峰, 律娜, 等. 益生菌促进胃肠道健康的机制及应用[J]. 微生物学报, 2022, 62(3): 836-847.
[89]	李玉勤, 孙映红, 梁亚鹏, 等. 益生菌联合应用行为分析法治疗儿童孤独症谱系障碍的前瞻性随机对照研究[J]. 中国当代儿科杂志, 2021, 23(11): 1103-1110.
[90]	廖想,李爽,曾瑶. 2012-2021年粪菌移植研究的趋势及热点分析[J]. 中华消化病与影像杂志（电子版）,2023,13(2):93-99.
[91]	曾凯丹, 温雪风, 王贵莲. 肠道菌群移植干预自闭症合并胃肠道症状患儿的效果评估[J]. 中国医学创新, 2023, 20(17): 1-5.
[92]	罗茜. 肠道微生态与孤独症谱系障碍相关性及粪微生态移植治疗的初步研究[D]. 北京: 中国人民解放军医学院, 2018.
[93]	周丛笑. 小儿运脾推拿法治疗孤独症谱系障碍的临床疗效及对肠道菌群的影响[D]. 北京: 北京中医药大学, 2021.

项目	结果	总数	研究文献
α多样性	↑	2	[30,34]
	↓	5	[15,31,33,36,42]
	-	5	[12,21,23,32,40]
β多样性	*	9	[13,18,23,29-32,40,42]
	-	2	[12,38]

菌群分类	总数	丰度升高	丰度降低
厚壁菌门	9	5^{[14,19,29-30,38]}	4^{[17,24,31,37]}
拟杆菌门	7	1^[37]	6^{[14,19,21,29-30,38]}
变形菌门	7	4^{[14,19,35,38]}	3^[11,21,37]
放线菌门	5	4^{[15,22-23,29]}	1^[38]
酸杆菌门	3	1^[31]	2^[17,24]

基于文献研究的中国孤独症儿童肠道菌群特征分析

Analysis of intestinal microbiome characteristics of children with autism in China based on literature research

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