ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (3): 185-190.

• 中医药治疗Meta分析专栏 •    下一篇

卫气营血辨证法治疗川崎病疗效的Meta分析

目的： 对卫气营血辨证法治疗川崎病的疗效进行Meta分析。
方法： 通过计算机及手工检索主题词，登录国内外各大数据库网站搜索相关文献，收集2005～2019年国内外公开发表的使用卫气营血辨证法治疗川崎病的随机对照临床研究文献。通过质量评价，依照文献纳入标准进行补充及再次筛选。干预措施为卫气营血辨证法治疗和西药常规治疗。采用 RevMan 5-3软件对筛选出的符合标准文献进行Meta分析。主要包含显效率、有效率、异质性及文献发表偏倚等。
结果： 共检索出相关文献195篇，最终纳入文献10篇共计701例川崎病儿童。显效率及有效率异质性结果分别为：χ2=6.09，P=0.73；χ2=2.61，P=0.98。表明不存在异质性，采用固定效应模型分析。卫气营血辨证法联合丙种球蛋白与单纯丙种球蛋白治疗川崎病显效率合并OR=1.97，95%CI（1.44，2.68），总体效果检验Z=4.29（P<0.000 1），差异有统计学意义。有效率合并OR=3.92，95%CI（2.24，6.86），总体效果检验Z=4.77（P<0.000 01），差异有统计学意义。Meta分析表明，使用卫气营血辨证法治疗川崎病总显效率及总有效率均明显优于单一西药，差异有统计学意义（P<0.05）。
结论: 卫气营血辨证法联合丙种球蛋白治疗川崎病总显效率及总有效率均明显高于单纯使用丙种球蛋白治疗，对提高患者临床疗效有一定优势，对指导临床用药有借鉴意义，值得临床推广应用。   

  1. 510623 广州，广州市妇女儿童医疗中心中医儿科
  • 出版日期:2021-06-25 发布日期:2021-12-15
  • 通讯作者: 邓健，E-mail：dengjian512@21cn.com
  • 作者简介:杨向娜（1985-），女，医学硕士，主治医师。研究方向：中医药防治川崎病的机制研究
  • 基金资助:
    广东省中医药局中医药科研项目（20201269）；广州市妇女儿童医疗中心院内基金（2990032）；广东省中医药局中医药科研项目（20181093）

Meta-analysis of the treatment for Kawasaki disease with Weiqi and Yingxue differentiation

Objective: To conduct a Meta-analysis of the efficacy of Weiqi Yingxue differentiation in the treatment of Kawasaki disease.#br# Methods: Through computer and manual retrieval of keywords,search related literatures by logging into major database websites at home and abroad,and collect the literatures of randomized controlled clinical studies on the treatment of Kawasaki disease with Weiqi Yingxue differentiation published at home and abroad from 2005 to 2019.Through quality evaluation,supplementary and re-screening were conducted according to the inclusion criteria of literature.Intervention measures were Weiqi Yingxue differentiation treatment and conventional western medicine treatment.RevMan 5-3 software was used to make a meta-analysis of the included literatures that met the standards.It mainly included significantly effective rate,effective rate,heterogeneity and publication bias.#br# Results: A total of 195 relevant literatures were retrieved,and a total of 701 children with Kawasaki disease in 10 literatures were finally included.The significant effective and effective heterogeneity were:χ2=6.09,P=0.73;χ2=2.61,P=0.98.The results showed that there was no heterogeneity.When using Weiqi Yingxue differentiation combined with gamma globulin and pure gamma globulin to treat Kawasaki disease,the significant effective rate combined with OR=1.97,95% CI (1.44,2.68),overall effect test Z=4.29 (P<0.000 1).The effective rate was combined with OR=3.92,95% CI (2.24,6.86),and the overall effect test Z=4.77 (P<0.000 01).The difference was statistically significant.Meta-analysis showed that the total significantly effective rate and total effective rate of Weiqi Yingxue differentiation in the treatment of Kawasaki disease were significantly better than those of western medicine alone (P<0.05).#br# Conclusion: The total significantly effective rate and total effective rate of Weiqi Yingxue differentiation combined with gamma globulin in the treatment of Kawasaki disease are significantly higher than those of gamma globulin alone,which has certain advantages in improving the clinical efficacy in patients and reference significance in guiding clinical medication,so it is worthy of clinical promotion and application.   

  1. Guangzhou Women and Children′s Medical Center,Guangzhou 510623,China
  • Online:2021-06-25 Published:2021-12-15

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摘要： 目的： 对卫气营血辨证法治疗川崎病的疗效进行Meta分析。
方法： 通过计算机及手工检索主题词，登录国内外各大数据库网站搜索相关文献，收集2005～2019年国内外公开发表的使用卫气营血辨证法治疗川崎病的随机对照临床研究文献。通过质量评价，依照文献纳入标准进行补充及再次筛选。干预措施为卫气营血辨证法治疗和西药常规治疗。采用 RevMan 5-3软件对筛选出的符合标准文献进行Meta分析。主要包含显效率、有效率、异质性及文献发表偏倚等。
结果： 共检索出相关文献195篇，最终纳入文献10篇共计701例川崎病儿童。显效率及有效率异质性结果分别为：χ2=6.09，P=0.73；χ2=2.61，P=0.98。表明不存在异质性，采用固定效应模型分析。卫气营血辨证法联合丙种球蛋白与单纯丙种球蛋白治疗川崎病显效率合并OR=1.97，95%CI（1.44，2.68），总体效果检验Z=4.29（P<0.000 1），差异有统计学意义。有效率合并OR=3.92，95%CI（2.24，6.86），总体效果检验Z=4.77（P<0.000 01），差异有统计学意义。Meta分析表明，使用卫气营血辨证法治疗川崎病总显效率及总有效率均明显优于单一西药，差异有统计学意义（P<0.05）。
结论: 卫气营血辨证法联合丙种球蛋白治疗川崎病总显效率及总有效率均明显高于单纯使用丙种球蛋白治疗，对提高患者临床疗效有一定优势，对指导临床用药有借鉴意义，值得临床推广应用。

关键词: 川崎病, 卫气营血辨证, 随机对照试验, Meta分析

Abstract: Objective: To conduct a Meta-analysis of the efficacy of Weiqi Yingxue differentiation in the treatment of Kawasaki disease.
Methods: Through computer and manual retrieval of keywords,search related literatures by logging into major database websites at home and abroad,and collect the literatures of randomized controlled clinical studies on the treatment of Kawasaki disease with Weiqi Yingxue differentiation published at home and abroad from 2005 to 2019.Through quality evaluation,supplementary and re-screening were conducted according to the inclusion criteria of literature.Intervention measures were Weiqi Yingxue differentiation treatment and conventional western medicine treatment.RevMan 5-3 software was used to make a meta-analysis of the included literatures that met the standards.It mainly included significantly effective rate,effective rate,heterogeneity and publication bias.
Results: A total of 195 relevant literatures were retrieved,and a total of 701 children with Kawasaki disease in 10 literatures were finally included.The significant effective and effective heterogeneity were:χ2=6.09,P=0.73;χ2=2.61,P=0.98.The results showed that there was no heterogeneity.When using Weiqi Yingxue differentiation combined with gamma globulin and pure gamma globulin to treat Kawasaki disease,the significant effective rate combined with OR=1.97,95% CI (1.44,2.68),overall effect test Z=4.29 (P<0.000 1).The effective rate was combined with OR=3.92,95% CI (2.24,6.86),and the overall effect test Z=4.77 (P<0.000 01).The difference was statistically significant.Meta-analysis showed that the total significantly effective rate and total effective rate of Weiqi Yingxue differentiation in the treatment of Kawasaki disease were significantly better than those of western medicine alone (P<0.05).
Conclusion: The total significantly effective rate and total effective rate of Weiqi Yingxue differentiation combined with gamma globulin in the treatment of Kawasaki disease are significantly higher than those of gamma globulin alone,which has certain advantages in improving the clinical efficacy in patients and reference significance in guiding clinical medication,so it is worthy of clinical promotion and application.

Key words: Kawasaki disease, Weiqi Yingxue differentiation, Randomized controlled trial, Meta-analysis