ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (3): 191-196.

• 中医药治疗Meta分析专栏 • 上一篇    下一篇

基于网状Meta分析探讨10种中成药辅助治疗儿童肺炎支原体肺炎的临床疗效

目的: 通过网状Meta分析系统评价10种中成药辅助治疗儿童肺炎支原体肺炎(MPP)的疗效。
方法: 计算机检索CNKI、VIP、CBM、Wan Fang Date、PubMed、Cochrane Library数据库，检索时间为建库至2020年9月，搜集关于中成药联合阿奇霉素治疗MPP患儿效果的临床试验的文献，由2名评价员独立筛选文献、提取数据及评价文献质量，以临床有效率作为结局指标，采用Revman 5.4、Stata 14.0软件进行网状Meta分析。
结果: 纳入文献48篇，共计4 895例MPP患儿，包括10种中成药，网状Meta分析显示：黄连颗粒/口服液、小儿豉翘清热颗粒、小儿肺咳颗粒、小儿肺热咳喘口服液、小儿消积止咳口服液、柴桂退热颗粒、金振口服液、麻甘颗粒、蒲地蓝消炎口服液联合阿奇霉素治疗儿童MPP的临床有效率优于单独使用阿奇霉素，其余药物两两比较差异无统计学意义；根据不同口服中成药累计排序曲线下面积（SUCRA）值的排序结果显示，在提高临床有效率方面，排在前4位的是：小儿肺咳颗粒、小儿消积止咳口服液、柴桂退热颗粒、小儿豉翘清热颗粒。
结论: 中成药辅助阿奇霉素治疗小儿MPP可提高临床有效率，且小儿肺咳颗粒、小儿消积止咳口服液、柴桂退热颗粒与小儿豉翘清热颗粒的效果较其他中成药更优。
  

  1. 110847 沈阳，辽宁中医药大学2018级中医儿科专业研究生（钟润锋，候宏彬，任园园，王雪飞）；110032 沈阳，辽宁中医药大学附属医院儿科（吴振起）
  • 出版日期:2021-06-25 发布日期:2021-12-15
  • 通讯作者: 吴振起，E-mail：zhenqiwu@163.com
  • 作者简介:钟润锋（1994-），男，辽宁中医药大学2018级硕士研究生在读。研究方向：中医药防治小儿呼吸系统疾病
  • 基金资助:
    国家自然科学基金面上项目（81874490）；辽宁省高等学校创新人才支持计划（LR2019040）

Exploration of the clinical efficacy of 10 kinds of Chinese patent medicines in adjuvant treatment of Mycoplasma pneumoniae pneumonia in children

Objective: To evaluate the efficacy of 10 Chinese patent medicines in adjuvant treatment of Mycoplasma pneumoniae pneumonia (MPP) in children through a network meta-analysis system.#br# Methods: Search the CNKI,VIP,CBM,Wan Fang Date,Pubmed,Cochrane Library databases,the search time being from the establishment of the database to September 2020;the literatures on clinical trials of Chinese patent medicine combined with azithromycin in the treatment of children with MPP was collected.Two reviewers screened the literatures,extracted data,and evaluated the quality of the literatures independently.The clinical effectiveness was used as the outcome index.Revman 5.4 and Stata 14.0 softwares were used to conduct network meta-analysis.#br# Results: A total of 48 literatures involving 4 895 children with MPP were included,concerning 10 Chinese patent medicines.The network meta-analysis showed:The clinical effectiveness of the combination of Huanglian Granules/Oral Liquid,Xiao′er Chiqiao Qingre Granules,Xiaoer Feike Granules,Xiaoer Feire Kechuan Oral Liquid,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Tuire Granules,Jinzhen Oral Liquid,Magan Granules and Podilan Antipyretic Oral Liquid with azithromycin in the treatment of children′s MPP was better than that of azithromycin alone.The other drugs showed no statistical difference when compared between each two.According to the ranking results of the surace under cumulative ranking area (SUCRA) value of different oral Chinese patent medicines,the top 4 medicines in terms of improving clinical efficiency were:Xiaoer Feike Granules,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Antipyretic Granules and Xiao′er Chiqiao Qingre Granules.#br# Conclusion: Chinese patent medicine assisting azithromycin in the treatment of children with MPP can improve the clinical effectiveness,and the effects of Xiaoer Feike Granules,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Antipyretic Granules and Xiao′er Chiqiao Qingre Granules are better than other Chinese patent medicines.   

  1. Liaoning University of Traditional Chinese Medicine,Shenyang 110847，China
  • Online:2021-06-25 Published:2021-12-15

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摘要： 目的: 通过网状Meta分析系统评价10种中成药辅助治疗儿童肺炎支原体肺炎(MPP)的疗效。
方法: 计算机检索CNKI、VIP、CBM、Wan Fang Date、PubMed、Cochrane Library数据库，检索时间为建库至2020年9月，搜集关于中成药联合阿奇霉素治疗MPP患儿效果的临床试验的文献，由2名评价员独立筛选文献、提取数据及评价文献质量，以临床有效率作为结局指标，采用Revman 5.4、Stata 14.0软件进行网状Meta分析。
结果: 纳入文献48篇，共计4 895例MPP患儿，包括10种中成药，网状Meta分析显示：黄连颗粒/口服液、小儿豉翘清热颗粒、小儿肺咳颗粒、小儿肺热咳喘口服液、小儿消积止咳口服液、柴桂退热颗粒、金振口服液、麻甘颗粒、蒲地蓝消炎口服液联合阿奇霉素治疗儿童MPP的临床有效率优于单独使用阿奇霉素，其余药物两两比较差异无统计学意义；根据不同口服中成药累计排序曲线下面积（SUCRA）值的排序结果显示，在提高临床有效率方面，排在前4位的是：小儿肺咳颗粒、小儿消积止咳口服液、柴桂退热颗粒、小儿豉翘清热颗粒。
结论: 中成药辅助阿奇霉素治疗小儿MPP可提高临床有效率，且小儿肺咳颗粒、小儿消积止咳口服液、柴桂退热颗粒与小儿豉翘清热颗粒的效果较其他中成药更优。

关键词: 肺炎支原体肺炎, 中成药, 阿奇霉素, 网状Meta分析

Abstract: Objective: To evaluate the efficacy of 10 Chinese patent medicines in adjuvant treatment of Mycoplasma pneumoniae pneumonia (MPP) in children through a network meta-analysis system.
Methods: Search the CNKI,VIP,CBM,Wan Fang Date,Pubmed,Cochrane Library databases,the search time being from the establishment of the database to September 2020;the literatures on clinical trials of Chinese patent medicine combined with azithromycin in the treatment of children with MPP was collected.Two reviewers screened the literatures,extracted data,and evaluated the quality of the literatures independently.The clinical effectiveness was used as the outcome index.Revman 5.4 and Stata 14.0 softwares were used to conduct network meta-analysis.
Results: A total of 48 literatures involving 4 895 children with MPP were included,concerning 10 Chinese patent medicines.The network meta-analysis showed:The clinical effectiveness of the combination of Huanglian Granules/Oral Liquid,Xiao′er Chiqiao Qingre Granules,Xiaoer Feike Granules,Xiaoer Feire Kechuan Oral Liquid,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Tuire Granules,Jinzhen Oral Liquid,Magan Granules and Podilan Antipyretic Oral Liquid with azithromycin in the treatment of children′s MPP was better than that of azithromycin alone.The other drugs showed no statistical difference when compared between each two.According to the ranking results of the surace under cumulative ranking area (SUCRA) value of different oral Chinese patent medicines,the top 4 medicines in terms of improving clinical efficiency were:Xiaoer Feike Granules,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Antipyretic Granules and Xiao′er Chiqiao Qingre Granules.
Conclusion: Chinese patent medicine assisting azithromycin in the treatment of children with MPP can improve the clinical effectiveness,and the effects of Xiaoer Feike Granules,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Antipyretic Granules and Xiao′er Chiqiao Qingre Granules are better than other Chinese patent medicines.

Key words: Mycoplasma pneumoniae pneumonia, Chinese patent medicine, Azithromycin, Network meta-analysis