ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (3): 242-245.doi: 10.20274/j.cnki.issn.1674-3865.2025.03.010

• 临床研究 • 上一篇    下一篇

小儿定喘口服液联合西医治疗小儿喘息性支气管炎的临床观察

肖海飞1, 王纳2()   

  1. 450000 郑州，河南中医药大学第五临床医学院（郑州人民医院）儿科（肖海飞）
    200000 上海，复旦大学附属儿科医院中医科（王纳）
  • 收稿日期:2024-08-22 修回日期:2025-02-15 出版日期:2025-06-25 上线日期:2025-06-25
  • 通讯作者: 王纳 E-mail:18203638814@163.com
  • 作者简介:肖海飞（1991?），女，医学硕士，主治医师。研究方向：小儿呼吸系统疾病的诊治
  • 基金资助:
    国家自然科学基金（青年科学基金）项目(82205189)

Clinical observation of Xiaoer Dingchuan oral solution combined with western medicine treatment in the treatment of children with asthmatic bronchitis

Haifei XIAO1, Na WANG2()   

  1. 1.The Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine(Zhengzhou People's Hospital), Zhengzhou 450000, China
    2.Pediatric Hospital Affiliated to Fudan University, Shanghai 200000，China
  • Received:2024-08-22 Revised:2025-02-15 Published:2025-06-25 Online:2025-06-25
  • Contact: Na WANG E-mail:18203638814@163.com
  • Supported by:
    National Natural Science Foundation of China(Youth Science Fund)(82205189)

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摘要：

目的 探讨在治疗小儿喘息性支气管炎中，除常规西医疗法外，加用小儿定喘口服液的临床价值。 方法 选取2022年2月至2024年2月郑州人民医院收治的喘息性支气管炎患儿80例，随机分为对照组和观察组各40例。对照组采用常规西医治疗，观察组在对照组治疗基础上加用小儿定喘口服液治疗，两组患儿均连续用药5 d。比较两组患儿的临床总有效率，咳嗽、喘息等临床症状体征消失时间，炎症因子（白细胞介素-4、白细胞介素-6、白细胞介素-10、γ干扰素）指标变化情况，以及不良反应发生情况。 结果 治疗后观察组总有效率为92.5%（37/40），高于对照组75.0%（30/40），差异有统计学意义（P=0.034）。观察组患儿咳嗽、喘息、哮鸣音、粗湿啰音消失时间短于对照组，差异有统计学意义（P<0.05）。两组患儿治疗后炎性因子指标白细胞介素-4、白细胞介素-6、白细胞介素-10、γ干扰素均低于治疗前，且观察组指标低于对照组，差异有统计学意义（P<0.05）。对照组与观察组出现的不良反应轻微，发生率比较差异无统计学意义（P=1.000）。 结论 小儿定喘口服液联合西医治疗小儿喘息性支气管炎相比于常规西医治疗，总有效率更高，改善临床症状效果更为显著，炎性因子指标恢复更明显，且不良反应发生率没有明显上升，值得临床上进一步探索使用。

关键词: 喘息性支气管炎, 炎症因子, 小儿定喘口服液, 儿童

Abstract:

Objective To explore the clinical value of adding Xiaoer Dingchuan oral solution to western medicine treatment in the treatment of children with asthmatic bronchitis. Methods From February 2022 to February 2024, 80 children with asthmatic bronchitis were treated in Zhengzhou People’s Hospital, and they were randomly divided into a control group(40 cases) and an experimental group(40 cases). The control group received conventional western medicine treatment, and the experimental group was treated with Xiaoer Dingchuan oral solution in addition to western medicine treatment. Both groups were treated continuously for 5 days. The total clinical effective rate, the disappearance time of clinical symptoms and signs such as cough and wheezing, the changes in inflammatory factor indexes [interleukin(IL)-4, IL-6, IL-10, interferon-γ(IFN-γ)], and the occurrence of adverse reactions were compared between the two groups. Results After treatment, the total effective rate of the experimental group was 92.5%(37/40), which was higher than 75.0%(30/40) of the control group, and the difference was statistically significant(P=0.034); the disappearance time of cough, gasping, wheezing and coarse moist rales in the experimental group was shorter than that in the control group(P<0.05). The inflammatory factor indexes (IL-4, IL-6, IL-10, and IFN-γ) after treatment in both groups were significantly lower than those before treatment, and the indexes in the experimental group were lower than those in the control group(all P<0.05). The adverse reactions in the control group and the experimental group were mild, and the incidence rate had no statistical difference(P=1.000). Conclusion Compared with the single use of western medicine treatment, the combined use of Xiaoer Dingchuan oral solution and western medicine treatment for children with asthmatic bronchitis has a higher total effective rate, a more significant improvement in the clinical symptoms, and a more obvious recovery of inflammatory factor indexes, and there is no significant increase in the incidence rate of adverse reactions, which is worthy of further exploration and use in clinical practice.

Key words: Asthmatic bronchitis, Inflammatory factor, Xiaoer Dingchuan oral solution, Child

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