Abstract: ObjectiveTo explore the effect of fastigial nucleus electric stimulation on learning memory of rats with hypoxicischemic brain damage.MethodsThirtysix cases of sevendayage Wistar rats were randomly divided into HIBD group and sham operation group.HIBD group was divided into model group and electric stimulation group.Left common carotid artery was ligatured and nitrogenoxygen mixture gas inhaled for 2 h,hence HIBD animal models of neonatal rats were made;link the equipment without electrical stimulation (sham operated group),link the device but not connected (model group),and link device and connected (electrical stimulation group) at the same time.Twelve rats were randomly divided into 7day intervention group(6 cases)and 14day intervention group(6 cases).After 7 days and 14 days intervention，(1)the two groups were pespectively detected by Ytype maze learning and memory of mice brain injury function;(2)after HE staining,observe nerve cells and nerve fibers by the optical microscope;(3)detect the brain white matter STAT3 protein expression levels by immunohistochemi.ResultBy Ytype maze test，total time in M group was longer than group E (P< 0.05);active avoid reaction rate and the correct response rate in M group was lower than E group (P< 0.05).In M group the total time increased significantly compared with group F(P< 0.05); in M group,active avoid reaction rate and the correct response rate was also significantly lower than group F (P< 0.05).In F group of structure and cellular level brain tissue of each place was clear,form normal,with no obvious harm change.In M group capillary hemorrhage could be seen obviously,nuclei became pyknotic,nuclear cataclasmproof obvious,so the model as a success.In Group E nerve cells degeneration necrosis was less,most cell forms were relatively normal.The signal transduction and transcription activated protein 3 (STAT3) around cortex and seahorses increased relatively more than model group (P< 0.05).ConclusionElectrical stimulation of the cerebellar fastigial nucleus can recover the learning memory ability of rats.

Key words: Electrical stimulation of cerebellum top nuclear, Learning memory, Brain damage, Ytype maze, STAT3