早期行为疗法降低仔鼠脑损伤致脑性瘫痪的实验研究

doi:10.3969/j.issn.1674-3865.2010.01.004

Abstract

Abstract: ObjectiveTo study the effect of early behavior therapy to reduce cerebral palsy caused by brain damage in rats.
MethodsTotally 27 pregnant rats were consecutively injected with LPS(450 μg/kg，n=21) or saline(n=6) on gestation 18 d and 19 d.We selected randomly saline neonatal rat group B(n=30) and LPS neonatal rat group A1(n=20)，A2(n=30).The 2 d rats(A1) were given early behavior therapy，such as enriched environment and the rats(A2 and B) were routinely fed.The neurobehavior of the rats was observed in A1，A2 and B groups on 25 d.The MBP and S100 were detected in brain sections on 1 d and 25 d.
ResultsMBP expression was obviously decreased in A2(1 d),compared with B of 1 d rats(P<0.01);MBP was increased in A1 of 25 d,compared with A2 of 25 d(P<0.05)；it was increased in B,contrasted with A1 and A2(P<0.01).Compared with B,there was significant increase in A2 of 1 d with regard to S100(P<0.01).The result of S100 between A2 and B of 25 d was the same with 1 d rats,but the S100 of A1 was the middle of them（P<0.01）．The result of neurobehavioral observation indicated that there were 4 cerebral palsy rats in A1,8 cerebral palsy rats in A2 and no cerebral palsy rat in B.
ConclusionMBP and S100 can become the sign of early diagnosis and the therapeutic effect in brain injury.Early interference can reduce cerebral palsy.

Key words: Cerebral palsy;Brain damage;Behavior therapy;Rat；Animal, experiment

PANG Wei，LI Xiaojie，ZHANG Shiling.. Experimental study of the early behavior therapy to reduce cerebral palsy of the young rats due to brain damage[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2010, 2(1): 8-12.

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Experimental study of the early behavior therapy to reduce cerebral palsy of the young rats due to brain damage

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