Abstract:
Objective：To observe the safety and the effect of fat emulsion on weight increase in very low birth weight infants.
Methods：From January 2012 to December 2014,82 very low birth weight infants in our hospital were randomly divided (by means of random number table)into two groups :the treatment group(42 persons) and the control group(40 persons).The treatment group received intravenous nutrition with fat emulsion within 24 hours after birth,the initial dose 0.5～1.0 g/（kg·d） with an increase of 0.5 g/kg daily;the maximum dose was 3.0 g/kg every day. The control group received fat emulsion from the fourth day after birth.The other methods were the same. Compare the weight growth, the time to return to normal weight,biochemical parameters and complications.
Results：The daily weight gain of the treatment group was significantly higher than the control group. The time to return to normal weight in the treatment group was shorter than the control group(P＜0.05）.There were no significant differences in biochemical indicators between the two groups(P＞0.05）. The risks of cholestasis, high bilirubin, and infection were increased in the treatment group.
Conclusion：Administration of a larger dose of fat emulsion in early premature infants can promote the weight gain, reduce the incidence of EUGR, and shorten the hospital stay, which has no influence on the rates of complications.

Key words: Very low birth weight infant, Parenteral nutrition, Fat emulsion, Complication, Infant;newborn