Abstract: Influenza virus infection is one of the most prevalent infectious diseases in the world.Influenza virus infection can induce bronchitis and pneumonia,but severe lethal pneumonia is observed when complications involve bacterial infections.Animal models play an important role in the study of co-infection with influenza virus and Streptococcus pneumoniae.Different animal models have different advantages and limitations.This article introduces commonly used animal species and determination methods of pathogens,and synthesize the choice of modeling time points for different research purposes and the determination methods of models.The current research progress of co-infection models at home and abroad is summarized,with a view to provide reference for basic and applied research on co-infection.

Key words: Influenza virus；Streptococcus pneumoniae, Co-infection, Animal model