ISSN 1674-3865  CN 21-1569/R
主管：国家卫生和计划生育委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
Chinese Pediatrics of Integrated Traditional and Western Medicine

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (3): 201-204.

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Research progress in animal models of co-infection by influenza virus and Streptococcus pneumoniae at home and abroad

Influenza virus infection is one of the most prevalent infectious diseases in the world.Influenza virus infection can induce bronchitis and pneumonia,but severe lethal pneumonia is observed when complications involve bacterial infections.Animal models play an important role in the study of co-infection with influenza virus and Streptococcus pneumoniae.Different animal models have different advantages and limitations.This article introduces commonly used animal species and determination methods of pathogens,and synthesize the choice of modeling time points for different research purposes and the determination methods of models.The current research progress of co-infection models at home and abroad is summarized,with a view to provide reference for basic and applied research on co-infection.   

  1. Liaoning University of Traditional Chinese Medicine，Shenyang 110000，China
  • Online:2021-06-25 Published:2021-12-15

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Abstract: Influenza virus infection is one of the most prevalent infectious diseases in the world.Influenza virus infection can induce bronchitis and pneumonia,but severe lethal pneumonia is observed when complications involve bacterial infections.Animal models play an important role in the study of co-infection with influenza virus and Streptococcus pneumoniae.Different animal models have different advantages and limitations.This article introduces commonly used animal species and determination methods of pathogens,and synthesize the choice of modeling time points for different research purposes and the determination methods of models.The current research progress of co-infection models at home and abroad is summarized,with a view to provide reference for basic and applied research on co-infection.

Key words: Influenza virus；Streptococcus pneumoniae, Co-infection, Animal model