Abstract: Objective:To analyze the effects of immune enteral nutrition(EN) combined with supplementary parenteral nutrition(SPN) on immune function and prognosis of children with severe viral encephalitis(SVE) under the management of individualized nutrition support.Methods:The clinical data of 98 SVE children treated in our hospital from August 2015 to August 2019 were retrospectively analyzed, and the patients were divided into observation group(n=52) and control group(n=46) according to different nutritional treatment methods. The patients in observation group were treated with individualized immune EN+SNP, and the children in control group were treated with routine EN+SNP. The nutritional status［transferrin(TRF), hemoglobin(Hb), serum albumin(ALB), prealbumin(PAB)］, immune function［immunoglobulins(IgA,IgM,IgG)］ and serum nerve function indicators［neuron-specific enolase(NSE), central nervous specific protein(S100β)］ were compared between the two groups before and after treatment. The children were given 6 months of follow-up, and the incidence rates of sequelae(mental retardation, dyskinesia, symptomatic epilepsy) were counted.Results:After treatment, the levels of TRF, Hb, ALB and PAB in the two groups were higher than those before treatment(P<0.05), but there were no statistically significant differences between the two groups(P>0.05). The levels of IgA, IgM, and IgG in the two groups were significantly higher than those before treatment, and the levels in observation group were higher than those in control group during the same period (P<0.05). The levels of NSE and S100β in the two groups were significantly lower than those before treatment(P<0.05), but there were no statistically significant differences between the two groups(P>0.05). At 6 months of follow-up, there was no statistical difference in the total incidence rate of sequelae between observation group and control group(P>0.05).Conclusion:EN combined with SPN under the management of individualized nutrition support can regulate the immune function and improve the prognosis of child patients with SVE.

Key words: Encephalitis, Viral, Enteral nutrition, Supplementary parenteral nutrition, Immune function, Prognosis