Abstract: Objective To observe the effect of intervention by neurodevelopmental therapy(NDT) on neurodevelopment of high-risk preterm infants and the sensitive indicators by rehabilitation intervention in high-risk preterm infants. Methods A total of 82 cases of preterm high-risk infants borned in our hospital from September 2019 to September 2021 were selected and randomly grouped into control group and intervention group.The family members were told about the risks of brain injury and ways of intervention in preterm high-risk infants.The control group(42 cases) was the conventional family rehabilitation group, and the intervention group(40 cases) was the NDT rehabilitation group. Both groups were intervened for 6 months to observe the degree of neurodevelopmental improvement after the intervention, including muscle tone, nervous system reflexes, growth and development(development quotient). Results There was no statistical significance in the difference between the two groups before the intervention(P>0.05); there was no statistical difference in neural reflexes and development quotients between the two groups before the intervention(P>0.05), but there were statistically significant differences between the two groups after the intervention(P<0.01). The Pearson correlation analysis was made and the results showed that the normal number of neural reflexes was related to the development quotient(r=0.829,P<0.01). Conclusion Abnormal neuroreflex examination in high-risk preterm infants, combined with muscle tone and growth development assessment,calls for NDT rehabilitation intervention in the children. Normal levels of neuroreflex can be clinically used as a sensitive indicator of rehabilitation interventions in high-risk preterm infants.

Key words:

Premature infants, High-risk children, Neurodevelopmental therapy, Neurodevelopment