Abstract: ObjectiveTo study the effect of nalmefene hydrochloride in the prevention of sufentanil-induced choking cough reaction during general anesthesia induction in children undergoing surgery. Methods Today 150 children, who underwent laparoscopic surgery for bilateral or unilateral hernia and hydrocele in our hospital from June 2021 to March 2022， were selected as the study subjects, and were randomly divided into an observation group and a control group with 75 cases each. The observation group was given 0.25 μg/kg nalmefene hydrochloride one minute before general anesthesia induction, while the control group was given the same amount of normal saline. The frequency of choking cough within one minute after injection of sufentanil, the vital signs of heart rate (HR), blood oxygen saturation (SpO2), mean arterial pressure (MAP), bispectral index (BIS) at 5, 10, 15 and 20 minutes and other adverse reactions were observed in the two groups.ResultsThe observation group had lower incidence of choking cough (0% ,0/75) and better control rate(100%,75/75) than the control group ［33.3%(25/75) and 66.7%(50/75)］ ,and the difference had statistical significance (P<0.05). However, no obvious difference was found in SBP, DBP, MAP, HR, SpO2 or BIS between the two groups at 5min, 10min and 20min(P>0.05). At 15min, SBP and BIS in the observation group were lower than those in the control group(P<0.05). No significant difference was found in DBP, MAP, HR or SpO2 between the two groups(P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups［4.0%(3/75) in control group vs 1.3%(1/75) in observation group］. Conclusion The administration of 0.25 μg/kg nalmefene hydrochloride one minute before anesthesia induction after entering the operation room can effectively prevent the sufentanil-induced choking cough reaction during general anesthesia in children, which does not affect the hemodynamics or increase the adverse drug reactions, so it can be safely used in clinic.

Key words:

Choking cough, Sufentanil, Nalmefene, Children