ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2010, Vol. 2 ›› Issue (6): 496-498.doi: 10.3969/j.issn.16743865.2010.06.007

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Investigate into the relationship between RELN gene single nucleotide polymorphism and childhood autism〖WT5"BX〗SUN Ying,SHENG Zhaoming,JIANG Zhimei,et al.Division of Pediatric Neurology,the Third Affiliated Hospital of Jiamusi University,Jiamusi 154003,China

  

  • Published:2010-12-25 Online:2019-06-10

Abstract:
ObjectiveTo investigate the relationship between RELN gene single nucleotide polymorphism and childhood autism in Han population in Jiamusi.MethodsPolymerase chain reactionrestricted fragment length polymorphism(PCRRFLP)was used to determine allele and genotype of SNP(exon 6)of RELN in Chinese Han autism children staying in the 3rd Affiliated Hospital of Jiamusi University and 30 normal children in a kindergarten and an elementary school in Jiamusi from January,2006 to December,2007.Results(1)There was a significant difference in the distribution of the allelic frequencies and genotype in exon 6 between the two groups(P<0.05).(2)There was no significant difference in the distribution of the allelic frequencies and genotype in Exon 50 between the two groups(P>0.05).Conclusions(1)There is an association between the SNP(exon 6) of RELN and childhood autism.(2)There is no association between the SNP(Exon 50)of RELN and childhood autism.

Key words: autism, gene RELN, single nucleotide polymorphism(SNP);psychology therapy;child psychology