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Investigate into the relationship between RELN gene single nucleotide polymorphism and childhood autism
SUN Ying, SHENG Zhao ming, JIANG Zhi mei
2010, 2 (6):
496-498.
doi: 10.3969/j.issn.1674=3865.2010.06.007
Objective：To investigate the relationship between RELN gene single nucleotide polymorphism and childhood autism in Han population in Jiamusi.Methods：Polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP)was used to determine allele and genotype of SNP(exon 6)of RELN in Chinese Han autism children staying in the 3rd Affiliated Hospital of Jiamusi University and 30 normal children in a kindergarten and an elementary school in Jiamusi from January,2006 to December,2007.Results：(1)There was a significant difference in the distribution of the allelic frequencies and genotype in exon 6 between the two groups(P＜0.05).(2)There was no significant difference in the distribution of the allelic frequencies and genotype in Exon 50 between the two groups(P>0.05).Conclusions：(1)There is an association between the SNP(exon 6) of RELN and childhood autism.(2)There is no association between the SNP(Exon 50)of RELN and childhood autism.
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