Abstract:
Objective
To observe the therapeutic effect of Guben Quyu Huashi decoction on pediatric nephrotic syndrome.
Methods
Fifty cases of children with nephrotic syndrome admitted to the Department of Pediatrics of Wuwei Liangzhou Hospital from June 2016 to June 2018 were selected as study subjects, and were randomly divided into control group (20 cases) and observation group (30 cases).Both groups were given routine treatment, and the observation group was also treated with Guben Quyu Huashi decoction for syndrome differentiation and modified treatment one dose per day and 12 weeks as one course of treatment. After one course of treatment, the clinical efficacy, biochemical indexes, urine protein conversion time and edema regression time of the two groups after treatment were observed.
Results
After treatment, plasma albumin was significantly higher in the two groups than before treatment, and urine protein and cholesterol were significantly lower in the 24h group than before treatment, with statistically significant differences (P<0.05).After treatment, plasma albumin in the observation group was significantly higher than that in the control group, and urine protein quantification and cholesterol in 24 hours were significantly lower than those in the control group, with statistically significant differences (P<0.05).After treatment, the plasma immunoglobulin of the observation group was significantly higher than that of the control group, and the duration of urine protein conversion to Yin and edema regression was significantly less than that of the control group, with statistically significant differences (P<0.05).The total effective rate in the observation group was higher than that in the control group［96.6%(29/30) vs 70.0%(14/20)］, and the difference was statistically significant(P<0.05).After treatment, the incidence of full moon face, infection, recurrence, gastrointestinal reaction and hyperglycemia in the observation group was lower than that in the control group, with statistically significant differences(P<0.05).There was no significant difference in the incidence of acne and hypotension between the two groups(P>0.05).
Conclusion
Guben Quyu Huashi decoction can significantly improve the effect of treatment for nephrotic syndrome, rapidly improve the clinical symptoms, with quick effect and less adverse reactions, which is worthy of clinical application.

Key words: Nephrotic syndrome, Guben Quyu Huashi decoction, Children