ISSN 1674-3865  CN 21-1569/R
主管：国家卫生和计划生育委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
Chinese Pediatrics of Integrated Traditional and Western Medicine

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (3): 234-236.

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Clinical analysis of hemophagocytic syndrome in children

Objective: To investigate the clinical features，diagnosis，individualized treatment and prognosis of hemophagocytic syndrome(HPS).#br# Methods: A retrospective study was carried out to analyze the clinical data of 24 HPS cases treated in our hospital from Sep. 2015 to Nov. 2018.#br# Results: The most common clinical manifestations were fever and splenomegaly.There were also central nervous involvement and acute liver failure as the first clinical manifestations of HPS.The features of laboratory data included cytopenia(29.2%)，coagulation disorder(83.3%)，high level of triglyceride(45.8%)，hepatic function damage(87.5%)，elevated lactate dehydrogenase(100%)，elevated C reactive protein(70.8%),calcium ion(25%)，reduced sodion(66.7%)，elevated ferritin(87.5%)，reduced activity of NK cells(91.75%)，and elevated level of sCD 25(100%); hemophagocytosis and histiocytes could be seen in bone marrow of 23 cases.#br# Conclusion: HPS has diverse clinical manifestations;therefore,good results can be obtained by early identification,early diagnosis,and trying to find the primary cause in order to perform individualized treatment.   

  1. Dalian Children′s Hospital，Dalian 116000，China
  • Online:2021-06-25 Published:2021-12-15

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Abstract: Objective: To investigate the clinical features，diagnosis，individualized treatment and prognosis of hemophagocytic syndrome(HPS).
Methods: A retrospective study was carried out to analyze the clinical data of 24 HPS cases treated in our hospital from Sep. 2015 to Nov. 2018.
Results: The most common clinical manifestations were fever and splenomegaly.There were also central nervous involvement and acute liver failure as the first clinical manifestations of HPS.The features of laboratory data included cytopenia(29.2%)，coagulation disorder(83.3%)，high level of triglyceride(45.8%)，hepatic function damage(87.5%)，elevated lactate dehydrogenase(100%)，elevated C reactive protein(70.8%),calcium ion(25%)，reduced sodion(66.7%)，elevated ferritin(87.5%)，reduced activity of NK cells(91.75%)，and elevated level of sCD 25(100%); hemophagocytosis and histiocytes could be seen in bone marrow of 23 cases.
Conclusion: HPS has diverse clinical manifestations;therefore,good results can be obtained by early identification,early diagnosis,and trying to find the primary cause in order to perform individualized treatment.

Key words: Hemophagocytic syndrome, Clinical characteristics, Individualized treatment