Abstract: ObjectiveTo systematically evaluate the efficacy and safety of Yupingfeng granules combined with conventional western medicine for acute exacerbation and remission of childhood asthma.Methods The databases of CNKI, Wanfang, VIP, CMB, Chinese Medical Journal Network, PubMed, Cochrane Library and Embase were searched for randomized controlled trials on the effect of Yupingfeng granules in management of childhood asthma. RevMan 5.4.1 was used to perform a Meta analysis.Results A total of 23 studies were included, with 1 147 subjects in acute exacerbation stage and 1 897 subjects in remission stage. The Meta analysis showed that compared with the control group, Yupingfeng granules significantly improved the effective rate in acute exacerbation(RR=1.24,P<0.001), and shortened duration of cough(MD=1.25,P<0.001),wheezing(MD=1.46,P<0.001) and pulmonary wheezing on auscultation(MD=1.39,P<0.001). For asthmatic children in remission stage, Yupingfeng granules significantly improved the effective rate(RR=1.22, P<0.001), reduced the number of acute exacerbation(MD=1.62,P<0.001) and respiratory infections(MD=3.19,P<0.001) and time of antibiotic use(MD=1.09,P<0.001), and significantly improved lung function, cellular immunity and humoral immunity(P<0.05). Yupingfeng granules significantly down-regulated IL-4, IL-9 and IL-17 levels(P<0.05), and up-regulated IFN-γ level(P<0.05). In addition, the incidence of adverse effect was comparable between the Yupingfeng granules group and the control group(P=0.19).Conclusion Yupingfeng granules combined with conventional western medicine can improve management efficacy of childhood asthma in acute exacerbation and remission stage, relieve symptoms of acute exacerbation, and reduce exacerbations during remission stage. Yupingfeng granules can also help to improve lung function, cellular immunity and humoral immunity, reduce inflammatory factors, and has good safety.

Key words:

Asthma, Yupingfeng granules, Acute exacerbation stage, Remission stage；Children