Abstract: Objective To explore the effects of inhaled nitric oxide (NO) on oxygen supply status,left heart function and platelet aggregation in neonates with persistent pulmonary hypertension (PPHN). Methods A total of 80 children with PPHN admitted to our hospital from April 2019 to March 2022 were selected as the study subjects and randomly divided into the conventional group and the combined group with 40 cases in each group.The conventional group was given high-frequency shock ventilation,and the combined group was given combined inhalation NO.The oxygen supply status,platelet aggregation function,left heart function and outcome of the two groups were compared. Results The results of covariance analysis showed that the levels of blood oxygen saturation (SaO2) and blood oxygen partial pressure (PaO2) at the end of 72h of intervention in the combined group were higher than those in the conventional group;the oxygenation index was lower than that of the conventional group;the difference was statistically significant (P<0.05).The platelet aggregation rate,P-selectin and platelet membrane glycoprotein (GPⅡb/Ⅲa) levels in the combined group at the end of 72h after intervention were lower than those in the conventional group,and the differences were statistically significant (all P<0.05).There was no significant difference in the early peak diastolic velocity (em) of left ventricular mitral ring between the two groups at the end of 72h after intervention (P>0.05).Left ventricular systolic peak velocity (sm) and left ventricular output in combined group were higher than those in conventional group at the end of 72h after intervention,and Tei index was lower than that in conventional group,the differences being of statistical significance (P<0.05).By Fisher′s exact probability test,the fatality rate was 0.00% (0/40) in the combined group and 7.50% (3/40) in the conventional group,the differences being of no statistical significance (P=0.241). Conclusion Inhalation of NO can regulate the left heart function,improve the oxygen supply status,regulate the platelet aggregation function and improve the survival rate of PPHN children.

Key words:

Persistent pulmonary hypertension, Inhalation of nitric oxide, Left heart function, Newborn