Abstract: Objective To explore the value of alanine aminotransferase(ALT),aspartate aminotransferase(AST) and serum albumin(ALB) combined with prothrombin time(PT) in judging the development and prognosis of heart failure in children. Methods The clinical data of 50 children with heart failure was retrospectively analyzed,and the children were divided into cardiac function grade Ⅱ group(n=15),cardiac function Ⅲ group(n=14) and cardiac function Ⅳ group(n=21) according to modified Ross heart function grading,and into survival group(n=31） and death group(n=19) according to prognosis.The levels of ALT,AST,ALB and PT among the groups were compared,and the correlation between ALT,AST,ALB,PT,Ross cardiac function classes and death from heart failure was analyzed. Results The median ALT level of all children with heart failure was 95.0(141.2) U/L,AST was 60.9(79.1) U/L,ALB was 35.3(7.1) g/L,and PT was (19.64±2.62)s.The differences in ALB,AST,ALT and PT among cardiac function grade Ⅱ,Ⅲ and Ⅳ groups were statistically significant(P<0.05).Except for the difference in ALB between cardiac function grade Ⅱ group and Ⅲ group(P>0.05),the differences in ALB,ALT and PT were statistically significant(P<0.05) between each two groups among other groups.There was a negative correlation between the degree of heart failure and ALB grade in all children(rs=-0.375,P<0.05),a positive correlation with ALT grade(rs=0.747,P<0.001),no correlation with AST grade(rs=0.275,P>0.05),and a positive correlation with PT grade(rs=0.352,P<0.05).Logistic regression analysis found that the higher the Ross cardiac function level,the higher the ALT value(OR=1.018,95%CI:1.006-1.030) and the higher the AST value(OR=1.010,95%CI:1.001-1.020),the greater the risk of death in children with cardiac exhaustion.Conclusion ALT,AST and ALB combined with PT,and modified Ross cardiac function grading can assess the severity of heart failure,and ALT combined with modified Ross grading score has important clinical significance in evaluating the prognosis.

Key words:

Heart failure, Alanine aminotransferase, Glutamate aminotransferases, Albumin, Prothrombin time, Prognosis, Children