Abstract: Objective To compare three different height prediction methods ［growth curve method, Bayley-Pinneau (B-P) method and new method］ in girls with precocious puberty of phlegm-dampness obstruction type after the treatment with Jianpi Ziyin prescription, and analyze their value in predicting adult height (PAH). Methods Forty precocious puberty girls with phlegm-dampness obstruction were chosen, who were treated in Pediatric Department of shanghai University of Traditional Chinese Medicine from Jan. 1,2005 to June 30,2016. Their mean age on visiting the hospital was 7.20±0.85 years old. Only Jianpi Ziyin prescription was used during the whole process of treatment. The treatment lasted for 2 years, and the girls' final height was followed up.  Greulich-Pyle atlas method and estimated PAH method were used, and the three methods were used to predict adult height， which was compared with the final height. Results The final height of the 40 girls was (164.46±4.66)cm. The PAH before treatment, at 1 year of treatment and when the drug was stopped was (156.35±5.24)cm,(157.11±5.42)cm and (159.74±4.37)cm by growth curve method; it was (161.84±7.40)cm， (163.18±7.46)cm and (165.83±5.95)cm by B-P method; it was (154.64±7.24)cm，(157.90±7.29)cm and (161.49±5.77)cm by new method.The comparison of PAH before treatment and when the drug was stopped among the groups showed statistical difference(P<0.05). Comparing the PAH at each treatment stage with the final height, there was no statistical difference in PAH by B-P method at more than one year of treatment (P>0.05). The PAH when the drug was stopped by growth curve method. B-P method and new method was all positively correlated with the final height(r=0.70,0.75,0.71),and the difference between final height and PAH was (4.72±3.48)cm, (-1.37±3.99)cm and (2.97±4.11)cm, with the 95%CI being 3.61 to 5.84, -2.64 to -0.90 and 1.66 to 4.29.Conclusion The Bayley-Pinneau method is more suitable for predicting adult height of girls with precocious puberty of phlegm-dampness obstruction type treated by Jianpi Ziyin prescription.

Key words:

Precocious puberty, Jianpi Ziyin prescription, Girl, Phlegm-dampness obstruction, Predicting adult height