Abstract: Objective:To analyze the clinical characteristics and pathogenic bacteria distribution of early-onset and late-onset neonatal sepsis, in order to aid in the early clinical diagnosis and treatment.Methods:From Jan. 2017 to Oct. 2017, 28 cases of early-onset neonatal sepsis and 31 cases of late-onset neonatal sepsis were treated in our hospital, and their clinical data were analyzed.Results:The incidence of apnea, abdominal distention and heart rate increase was significantly higher in late onset group (P<0.05). There was no statistical difference in the incidence of abnormal body temperature, milk decrease, jaundice, skin empyesis or shortness of breath. Percentage of elevated C-reactive protein in late-onset group was significantly higher than that in early-onset group (P<0.05). There was no statistical difference in the percentage of abnormal WBC or platelet decrease. Streptococcus agalactiae was detected with the highest frequency in early-onset group(25%,7/28), while klebsiella pneumonia was the most frequently detected strain in late-onset group(38.71%,12/31).Conclusion:The symptoms of apnea, abdominal distention and heart rate increase are more common in late-onset neonatal sepsis than in early-onset neonatal sepsis. C-reactive protein is an important indicator in early evaluation of late-onset neonatal sepsis. Early-onset and late-onset neonatal sepsis differ in the distribution of pathogenic bacteria. Antibiotics should be used according to actual clinical conditions.

Key words: Neonatal sepsis, Early-onset sepsis, Late-onset sepsis, Pathogen, Infant, newborn