ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2010, Vol. 2 ›› Issue (6): 496-498.doi: 10.3969/j.issn.1674=3865.2010.06.007

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Investigate into the relationship between RELN gene single nucleotide polymorphism and childhood autism

SUN Ying,SHENG Zhao ming,JIANG Zhi mei   

  1. Division of Pediatric Neurology,the Third Affiliated Hospital of Jiamusi University,Jiamusi 154003,China
  • Received:2010-09-22 Published:2010-12-25 Online:2010-12-25

Abstract: Objective:To investigate the relationship between RELN gene single nucleotide polymorphism and childhood autism in Han population in Jiamusi.Methods:Polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP)was used to determine allele and genotype of SNP(exon 6)of RELN in Chinese Han autism children staying in the 3rd Affiliated Hospital of Jiamusi University and 30 normal children in a kindergarten and an elementary school in Jiamusi from January,2006 to December,2007.Results:(1)There was a significant difference in the distribution of the allelic frequencies and genotype in exon 6 between the two groups(P<0.05).(2)There was no significant difference in the distribution of the allelic frequencies and genotype in Exon 50 between the two groups(P>0.05).Conclusions:(1)There is an association between the SNP(exon 6) of RELN and childhood autism.(2)There is no association between the SNP(Exon 50)of RELN and childhood autism.

Key words: autism, gene RELN, single nucleotide polymorphism(SNP);psychology therapy;child psychology