Abstract: Objective:To explore the clinical effect of sodium valproate in the treatment of cerebral palsy combined with subclinical epileptiform discharge.
Methods:A total of 62 cases of cerebral palsy with subclinical epileptiform discharge were randomly divided into two groups，31 cases in each group. All the children received routine comprehensive rehabilitation treatment. On the basis of the above treatment，the observation group was given 20-40 mg/(kg·d) of sodium valproate oral solution，the blood concentration of which was controlled at 50-100 mg/L，and the course of treatment was 6 months. The control group did not use drugs. During the experimental period，each group was divided into two types according to whether there was clinical seizure or not. After six months of treatment, video EEG was examined to observe the control of epileptiform discharge. According to the results of EEG,the children with epileptiform discharge were divided into three categories: disappearance，improvement and no change. GMFM was used to observe the improvement of motor function.
Results:During the follow-up period, one case in observation group and two cases in control group were lost. Six cases in observation group were complicated by clinical epileptic seizure, obviously fewer than the control group(13 cases), the difference being statistically significant(P<0.05). After treatment, the re-examination of EEG showed that the effective rate in observation group was 83.33%(25/30) for controlling subclinical epileptiform discharge in children with cerebral palsy, significantly higher than that in control group(34.48%, 10/29)（P<0.05）. Oral administration of sodium valproate in the observation group could improve the motion function more significantly, and there was statistical difference(P<0.05).
Conclusion:Long term oral administration of valproate can effectively control or reduce the occurrence of epileptiform discharge and reduce the probability of clinical seizure in children with cerebral palsy who have subclinical epileptiform discharge. It can improve the motor function of children and improve the effect of rehabilitation treatment.
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Key words: Cerebral palsy, Subclinical epileptiform discharges, Sodium valproate, Child