Abstract: Objective To explore the clinical effect of budesonide combined with heating humidification high-frequency oscillatory ventilation in the treatment of severe premature respiratory distress syndrome. Methods A total of 120 premature infants with severe respiratory distress syndrome who were treated in our hospital from August 2020 to August 2022 were randomly divided into the experimental group (60 cases) and the control group (60 cases) by random number table method.Both groups of children were treated with heating humidification high-frequency oscillatory ventilation,and the experimental group was treated with budesonide on this basis.The clinical effects of the two groups were compared.The blood gas indexes,inflammatory factors and lung function indexes of the two groups were compared before and after treatment.The withdrawal failure and complications of the two groups were compared.Results There was no significant difference in PaO2,PaCO2,pH,OI,CC16 and BMP-7 levels between the two groups before treatment(P>0.05).After treatment,PaO2 and pH in the experimental group were significantly higher than those in the control group,and PaCO2,OI,CC16 and BMP-7 levels were significantly lower than those in the control group(P<0.05).After treatment,PaO2 and pH at each time point in the two groups were significantly higher than those before treatment,and PaCO2,OI,CC16 and BMP-7 levels were significantly lower than those before treatment(P<0.05).After treatment,VPEF/VE,VT and TPEF/TE in the experimental group were significantly higher than those in the control group(P<0.05).The effective rate of treatment in the experimental group was 96.7%(58/60),which was not significantly different from 90.0%(54/60) in the control group(P>0.05).The incidence of complications in the experimental group was 11.7%(7/60),which was significantly lower than 26.7%(16/60) in the control group(P<0.05).Conclusion In the treatment of premature infants with severe respiratory distress syndrome,budesonide combined with heating and humidification high-frequency oscillation can effectively improve the clinical efficacy,significantly improve the blood gas index,inflammatory factor level and lung function of the children,and reduce the incidence of complications.

Key words:

Severe premature respiratory distress syndrome, Budesonide, Heating humidification high-frequency oscillation ventilation