多维度探讨维生素D在儿童疾病中的应用进展

doi:10.20274/j.cnki.issn.1674-3865.2025.06.006

Abstract

Abstract:

Vitamin D, an essential fat-soluble vitamin for the human body, has long been recognized for its critical role in regulating calcium and phosphorus metabolism and supporting skeletal health. In recent years, a great number of clinical studies have proved that there is a significant association between vitamin D deficiency or insufficiency and the development of multisystem disorders in pediatric population. Particularly during key developmental stages in childhood, the immunomodulatory, anti-inflammatory, and organ-developmental effects of vitamin D have attracted much attention. This article provides a comprehensive review of the research progress in the application of vitamin D in pediatric conditions affecting the respiratory, gastrointestinal, immune, neurological and urinary systems as well as in infectious diseases, with the aim of providing references for the rational clinical use of vitamin D in pediatric population.

Key words: Vitamin D, Multisystem diseases, Application progress, Child

CLC Number:

R977.2+4

Ziwei WANG, Xiaolan SHU, Xi MING, Anmin WANG, Yi BI, Yi LONG, Qianyuan ZENG, Wang LI. A comprehensive study on the application progress of vitamin D in pediatric diseases[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(6): 493-497.

References 17

[1]	Liu Z, Huang S, Yuan X, et al. The role of vitamin D deficiency in the development of paediatric diseases[J]. Ann Med, 2023, 55(1): 127-135.
[2]	Chinese Society of Preventive Medicine, Child Health Branch. 中国儿童维生素A、维生素D临床应用专家共识(2024)[J]. 中国儿童保健杂志, 2024, 32(4): 349-358.
[3]	Aggeletopoulou I, Marangos M, Assimakopoulos SF, et al. Vitamin D and microbiome molecular interaction in inflammatory bowel disease pathogenesis[J]. Am J Pathol, 2023, 193(6): 656-668.
[4]	方勇. 维生素D对儿童反复呼吸道感染免疫调节作用的研究[J]. 中国处方药, 2021, 19(1): 101-102.
[5]	赵莹,姚丛月.血清25-羟维生素D水平与儿童肺炎支原体肺炎心肌损伤的相关性研究[J].临床肺科杂志, 2023, 28(7):1020-1023.
[6]	Das RR, Singh M, Naik SS. Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia[J]. Cochrane Database Syst Rev, 2023, 1(1): CD011597.
[7]	陈海萍, 赵方梅. 维生素D缺乏对儿童哮喘发病及哮喘控制的影响[J]. 临床医学研究与实践, 2024, 9(27): 18-21.
[8]	陈琳, 梁彩文, 龙丽娜. 维生素D辅助治疗小儿支气管哮喘的效果及对肺功能的影响[J]. 中国现代药物应用, 2021, 15(12): 181-183.
[9]	Fedora K, Setyoningrum RA, Aina Q, et al. Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials[J]. Ann Med, 2024, 56(1): 2400313.
[10]	纪展鹏, 魏兵. 儿童哮喘与血清25羟维生素D的双向两样本孟德尔随机化研究[J]. 中国中西医结合儿科学, 2024, 16(2): 148-154.
[11]	中华医学会消化病学分会炎症性肠病学组儿科协作组, 中华医学会儿科学分会临床营养学组. 儿童炎症性肠病诊疗中心质量控制标准专家共识[J]. 中华儿科杂志, 2023, 61(2): 117-121.
[12]	周丹丽, 林琼, 倪竹梦, 等. 儿童炎症性肠病微量营养素缺乏研究进展及治疗建议[J]. 药学与临床研究, 2022, 30(6): 536-540.
[13]	薛燕, 李蔚然, 王萍, 等. 炎症性肠病患儿维生素D营养状况的meta分析[J]. 重庆医学, 2024, 53(20): 3132-3137.
[14]	Torres DJ, Pitts MW, Hashimoto AC, et al. Agrp-specific ablation of scly protects against diet-induced obesity and leptin resistance[J]. Nutrients, 2019, 11(7): 1693.
[15]	申洋, 李昌平. 补充维生素D对炎性肠病患者肠道微生物群的稳态分析[J]. 中国病原生物学杂志, 2024, 19(9): 1047-1052.
[16]	Vernia F, Valvano M, Longo S, et al. Vitamin D in inflammatory bowel diseases. mechanisms of action and therapeutic implications[J]. Nutrients, 2022, 14(2): 269.
[17]	Tuncalp Ö, Rogers LM, Lawrie TA, et al. WHO recommendations on antenatal nutrition: an update on multiple micronutrient supplements[J]. BMJ Glob Health, 2020, 5(7): e003375.

A comprehensive study on the application progress of vitamin D in pediatric diseases

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