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25 June 2014, Volume 6 Issue 3 Previous Issue    Next Issue

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Behavioral study of Longmu Guizhi decoction on ADHD model rats   HE Ping，TANG Yan,YANG Ruo jun. 2014, 6 (3):  203-205.  doi: 10.3969/j.issn.1674-3865.2014.03.005 Abstract ( 469 )   PDF (387KB) ( 166 )   Save Objective:To investigate the effect of Longmu Guizhi decoction(LD) on locomotor activity and nonselective attention of juvenile SHR(spontaneously hypertensive rat)——a rat model of attention deficit hyperactivity disorder. Methods:Forty-eight SHR male  were randomly divided into high-dose LD group, middle-dose LD group, methylphenidate control group and saline control group. All the SHRs were lavaged for 14 days. Locomotor activity and nonselective attention were examined by openfield test and Làt maze test respectively before and after intervention. Results :In openfield test ,the number of square crossing and rearing after intervention of methylphenidate and decoctions in SHRs was significantly fewer than the saline group (P<0.01). The number of the above items in methylphenidate group was significantly fewer than middle-dose LD group (P<0.05). There was no difference between methylphenidate group and high-dose LD group（P>0.05).In Làt maze test, frequency of leaning against the wall after intervention of methylphenidate and decoctions in SHRs was significantly increased compared with the saline group (P<0.01), and that of high-dose LD group was significantly higher than the methylphenidate group and middledose LD group(P<0.05). Conclusion :Longmu Guizhi decoction can reduce locomotor activity and improve non-selective attention of ADHD model rats,which presents some kind of dose-effect relationship. Related Articles | Metrics

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The effect of hyperbilirubinemia on serum neuron-specific enolase(NSE) and neurological behavior in the neonates GUO Chun-yan. 2014, 6 (3):  221-224.  doi: 10.3969/j.issn.1674-3865.2014.03.012 Abstract ( 300 )   PDF (498KB) ( 110 )   Save Objective:To investigate the relationship among serum neuron-specific enolase(NSE),total serum bilirubin and neurological behavior in neonates with hyperbilirubinemia. Methods:A total of 86 cases of newborn hyperbilirubinemia were included in the boservation group,while 86 normal term newborns were choose as the control group.Enzymelinked immunosorbent assay was used to determine serum concentration of NSE and total serum bilirubin.NBNA score was also determined. Results:The serum concentrations of NSE and TSB in the observation group were significantly higher than those in the control group(P<0.01);two indicators decreased significantly after treatment.NBNA scores were significantly lower than the control group(P<0.01);After treatment they increased and were close to normal.NSE serum concentration and NBNA score showed a significant negative correlation(P<0.01)，but it was positively correlated with the TSB concentration. Conclusion: Serum NSE is significantly higher in the hyperbilirubinemia neonates than in the normal ones,which can be an indicator for early prediction of neonatal bilirubin brain injury; Hyperbilirubinemia has some influence on neonatal neurobehavior. Related Articles | Metrics