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25 April 2015, Volume 7 Issue 2 Previous Issue    Next Issue

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The changed of CXCL16 and ADAM10 in children with primary nephrotic syndrome interfered by Shenkangling decoction ZHENG Jian，AI Si，YANG Fan，et al 2015, 7 (2):  112-115.  doi: 10.3969/j.issn.1674-3865.2015.02.005 Abstract ( 347 )   PDF   Save Objective：To observe the levels of CXCL16,a disintegrin and metalloprotease 10(ADAM10) in children with primary nephrotic syndrome(PNS) before and after intervention of traditional Chinese medicine Shenkangling,and to clarify the mechanism of PNS and the action of Shenkangling by molecular biology. Methods：PNS children were randomly divided into the Shenkangling + western medicine group(n=30) and the western medicine group(n=30),and healthy children as normal control group were selected in the examination center(n=30).Serum CXCL16,ADAM10 were detected by ELISA in children with PNS before and after treatment, and at the same time, serum albumin(ALB), cholesterol(CH) and 24hour urinary protein excretion efficacy evaluation were detected. Results：In PNS children urinary protein excretion was elevated, serum ALB reduced,CH increased,CXCL16 and ADAM10 content increased(P<0.01).Compared to western medicine group, in Shenkangling + western medicine group CH and serum CXCL16 and ADAM10 content was reduced, serum ALB increased more significantly(P<0.01 or P<0.05).Both in Shenkangling + western medicine group and in western medicine group urine protein was decreased, but there was no difference between them. Conclusion：CXCL16 and ADAM10 are involved in the pathogenesis of PNS,and traditional Chinese medicine Shenkangling can significantly reduce the levels of serum CXCL16 and ADAM10,reduce the urine protein and CH and elevate ALB, thus improving symptoms in children, which may be related to removal of serum CXCL16 by clearing up oxLDL. Related Articles | Metrics

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Clinical efficacy and economic analysis of combined treatment with Chinese and Western medicine for pediatric bronchopneumonia GAO Zhongqiu, Huang Jing, Pang Jie，et al. 2015, 7 (2):  115-117.  doi: 10.3969/j.issn.1674-3865.2015.02.006 Abstract ( 260 )   PDF (334KB) ( 70 )   Save Objective：Study of the therapeutic efficiency of the combinational treatment of ChineseWestern medicine for pediatric bronchopneumonia. Method：120 of pediatric bronchopneumonia patients were divided into two groups randomly, 60 cases for each group. Group one was treated with both Chinese and Western medicine and group two was treated with Western medicine only. The group one had antibiotics and modified Chinese herbal formula Qiang yuan su fei; the group two was given antibiotics and drinking water with brown sugar added. Both were monitored during hospitalization period, and the clinical curative effect of seventh and tenth days were reviewed. Results：Significant difference between the two groups in the improvement of symptoms, signs and hospitalization time(P＜0.01）. In seventh day the cure rate of the group one was 61.6%, the total effective rate was 91.6%, significantly better than the group two with the cure rate of 41.6% and 76.6% of the total efficiency(P＜0.05）. In tenth day the cure rate of the group one was 81.6%, the cure rate of the group two of 68.3% at the same time, the group one was slightly better than the group two, but the difference was not statistically significant (P>0.05). The group one per capita cost 632 yuan, compared with the group two of 21.35% reduction(P＜0.01). Conclusion：The combinational treatment with both Chinese and Western medicine for pediatric bronchopneumonia can improve the clinical curative effect and cure rate, shorten the treatment time and cost savings. Related Articles | Metrics