关键词: 抽动症, 数据挖掘, 湖湘医派, 临床经验, 用药特色, 儿童

Abstract:

Objective Using data mining techniques to analyze the clinical experience and medication characteristics of the Huxiang School of Pediatric Medicine in treating pediatric tic disorders, this study aims to provide insights and references for the clinical management of pediatric tic disorders. Methods By collecting prescriptions for treating pediatric tic disorders from Essence of Famous Doctors' Classics in Huxiang, we input the data into Excel 2021 to establish a database. Using the IBM SPSS Statistics 27.0 platform, we analyzed the standardized TCM prescription data, including drug usage frequency, properties and flavors, meridian tropism, efficacy, association rules, and hierarchical clustering. The results were visualized using Origin 2024 and ModelerClient. Results A total of 127 TCM prescriptions were included, involving 117 Chinese medicinal herbs, with a total drug usage frequency of 995 times. Regarding properties and flavors, the dominant properties were warm and cold, while the predominant flavors were pungent and sweet. In terms of meridian tropism, the lung and spleen meridians were the most frequently involved, followed by the liver and heart meridians. Analysis of drug association rules revealed commonly used drug combinations, including "Bombyx Batryticatus(Jiangcan)–Scorpio (Quanxie), Typhonium Rhizome(Baifuzi)" and "Gastrodia Rhizome(Tianma)–Typhonium Rhizome(Baifuzi), Scorpio(Quanxie)".Hierarchical clustering analysis was performed on high-frequency herbs with usage frequency>5, resulting in 6 clusters, which were as follows:C1: Glycyrrhiza Radix et Rhizoma(Gancao), Paeoniae Radix Alba(Baishao), Cinnamomi Ramulus(Guizhi), Citri Reticulatae Pericarpium(Chenpi), Zingiberis Rhizoma Recens(Shengjiang);C2: Saposhnikoviae Radix(Fangfeng), Chuanxiong Rhizoma(Chuanxiong), Notopterygii Rhizoma et Radix(Qianghuo), Aurantii Fructus(Zhike), Angelicae Pubescentis Radix(Duhuo), Peucedani Radix(Qianhu), Platycodonis Radix(Jiegeng), Bupleuri Radix(Chaihu), Rhei Radix et Rhizoma(Dahuang), Ephedrae Herba(Mahuang), Scutellariae Radix(Huangqin), Menthae Herba(Bohe), Schizonepetae Herba(Jingjie), Talcum(Huashi);C3: Angelicae Sinensis Radix(Danggui), Poria cum Radix Pini(Fushen), Uncariae Ramulus Cum Uncis(Gouteng), Ophiopogonis Radix(Maidong), Akebiae Caulis(Mutang);C4: Ginseng Radix et Rhizoma(Renshen), Poria(Fuling), Atractylodis Macrocephalae Rhizoma(Baizhu), Aucklandiae Radix(Muxiang), Glycyrrhizae Preparata Radix(Zhigancao), Cinnamomi Cortex(Rougui), Aconiti Lateralis Radix Praeparata(Fuzi)C5: Scorpio(Quanxie), Bombyx Batryticatus(Jiangcan), Gastrodia Rhizome(Tianma), Typhonium Rhizome(Baifuzi), Arisaema Cum Bile(Dannanxing), Amber(Hupo), Cinnabaris(Zhusha), Moschus(Shexiang), Bovis Calculus(Niuhuang), Bambusae Concretio Silicea(Tianzhuhuang), Scolopendra(Wugong), Pinelliae Rhizoma(Banxia);C6: Natrii Sulfas(Mangxiao). Conclusion The Huxiang School of Pediatric Medicine treats pediatric tic disorders mostly from the perspectives of soothing the liver, regulating the spleen and resolving phlegm, forming a distinctive approach characterized by "tonifying the acquired foundation and focusing on benefiting qi and invigorating the spleen, with soothing the liver to calm endogenous wind and resolving phlegm to stop convulsions as auxiliary therapies". It features a clear differentiation between the principal and auxiliary treatments, synergistic effects of medicinal categories and rigorous compatibility of herbs, and adheres to the core philosophy of "taking invigorating the spleen as the root and calming wind to resolve phlegm as the apparent treatment".

Key words: Tic disorders, Data mining, Huxiang Medical School, Clinical experience, Medication characteristics, Child