氧化应激在儿童病毒性肺炎中的作用机制及中西医干预研究进展

doi:10.20274/j.cnki.issn.1674-3865.2026.03.005

摘要/Abstract

摘要：

儿童病毒性肺炎是常见的下呼吸道感染性疾病，氧化应激在其发生发展中起着关键作用。病毒感染可诱发活性氧自由基风暴，打破机体氧化-抗氧化平衡，并通过激活Toll样受体、核因子κB及核转录因子红系2相关因子2等关键信号通路，促进病毒复制、过度炎症反应与肺组织损伤。目前，针对该病的抗氧化治疗研究已成为热点。本文在阐明氧化应激核心机制的基础上，进一步综述了中西医的干预策略。深入探讨氧化应激机制并整合中西医抗氧化策略，将为儿童病毒性肺炎的临床防治提供新的思路与药物研发靶点。

关键词: 病毒性肺炎, 氧化应激, 信号通路, 抗氧化剂, 中医药治疗, 儿童

Abstract:

Viral pneumonia is a common lower respiratory tract infection in children, and oxidative stress plays a pivotal role in its occurrence and development. Viral infection can induce a storm of reactive oxygen species, disrupting the systemic oxidant-antioxidant balance, and promoting viral replication, excessive inflammatory responses and lung tissue damage by activating key signaling pathways such as Toll-like receptors(TLR), nuclear factor kappa-B(NF-κB), and nuclear factor erythroid-2 related factor 2(Nrf2). Currently, antioxidant therapy for this disease has become a focus of research. Based on elucidating the core mechanism of oxidative stress, this article reviews interventional strategies of traditional Chinese and western medicine. An in-depth exploration of the oxidative stress mechanism is made and antioxidant strategies based on TCM and western medicine are integrated, which will provide novel insights and drug development targets for the clinical prevention and treatment of viral pneumonia in children.

Key words: Viral pneumonia, Oxidative stress, Signaling pathway, Antioxidant, Traditional Chinese medicine therapy, Child

中图分类号:

R725.6

李木子, 周朋. 氧化应激在儿童病毒性肺炎中的作用机制及中西医干预研究进展[J]. 中国中西医结合儿科学, 2026, 18(3): 214-219.

Muzi LI, Peng ZHOU. Mechanism of oxidative stress in children with viral pneumonia and research advances in integrated Chinese and western medicine interventions[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2026, 18(3): 214-219.

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