肠道菌群参与新生儿黄疸的机制及研究进展

doi:10.20274/j.cnki.issn.1674-3865.2025.05.004

Abstract

Abstract:

The neonatal period represents a critical period for gut microbiota colonization and immune system development, exerting profound impacts on individual health. Neonatal jaundice is the most common clinical manifestation during this period, and its pathological process is closely associated with the imbalance of bilirubin metabolism. Gut microbiota plays a pivotal role in bilirubin metabolism through regulating the enterohepatic circulation. This review systematically reviews the composition and development of neonatal gut microbiota, provides an in-depth analysis of its role in bilirubin metabolism and its effects on serum bilirubin levels, and elaborates in detail on the potential mechanisms of enzymatic reactions, immune regulation and intestinal barrier function that affect bilirubin metabolism. The aim is to provide theoretical basis for clinical prevention and treatment of neonatal jaundice, thereby promoting the healthy development of neonates.

Key words: Neonatal jaundice, Gut microbiota, Enterohepatic circulation, Bifidobacterium

CLC Number:

R722.17

Xin PENG, Yuqian WANG, Liu YANG. Mechanism and research progress of gut microbiota involved in neonatal jaundice[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(5): 382-386.

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Mechanism and research progress of gut microbiota involved in neonatal jaundice

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