Abstract: Objective: To study the clinical value of the changes in blood flow parameters of lenticulostriate artery in the evaluation of neonates with hypoxic ischemic encephalopathy(HIE).Methods: A total of 80 children with HIE treated in our hospital from Jan. 2018 to Feb. 2020 were included as the observation group, among whom 32 were mild, 22 were moderate and 26 were severe. During the same period, 40 healthy neonates were chosen as the control group. The changes in peak systolic velocity(Vs), end-diastolic velocity(Vd) and resistance index(RI) of lenticulostriate artery at 24h, 48h and 72h after birth were determined.Results: At 24h after birth, the Vs and Vd of lenticulostriate artery in HIE children of observation group were significantly lower than those in control group, and RI was significantly increased compared with control group, the differences being statistically significant(P<0.05). There were also statistical differences in Vs, Vd and RI between mild HIE children and moderate and severe HIE children(P<0.05). There was no statistical difference in Vs, Vd or RI between moderate groups and severe group(P>0.05). At 48h and 72h after birth, the Vs, Vd and RI in mild and severe HIE children were close to normal or completely normal(P>0.05), while they were still lower in severe group than in mild, moderate and control group, and RI was continuously increasing, the differences being of statistical significance(P<0.05).Conclusion: The changes in blood flow parameters of lenticulostriate artery have significant clinical value in the evaluation of brain injury in HIE children, which can provide imaging evidence for early clinical intervention.

Key words: Hypoxic-ischemic encephalopathy, Craniocerebral ultrasound, Lenticulostriate artery, Neonate