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Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (5): 399-401.

Value of the combination detection of β2-microglobulin and neutrophil gelatinase-associated lipocalin in early renal injury in children with infectious mononucleosis

Objective:To study the value of combination detection of β2-microglobulin and neutrophil gelatinase-associated lipocalin(NGAL) in the diagnosis of early renal injury in children with infectious mononucleosis (IM).#br# Methods:Totally 85 children with IM were chosen, who were hospitalized for treatment from Jan. 2016 to Oct. 2019. They were divided into renal injury group(42 children，group A) and no-renal-injury group(43 children, group B). Forty healthy children receiving physical examination in our hospital in the same period were included as the healthy control group(group C). Compare the levels of urinary β2-microglobulin, NGAL, microalbumin/creatinine and NAG.#br# Results:The level of β2-microglobulin, NGAL, microalbumin/creatinine and NAG and the positive rate in group A were all higher than those in group B and group C, and the difference was statistically significant(P<0.05). There was no statistical difference between group B and group C(P<0.05).#br# Conclusion:The combination detection of β2-microglobulin, NGAL, microalbumin/creatinine and NAG is effective in the diagnosis of early renal injury in children with infectious mononucleosis. The samples are easy to obtain and the operation is simple, which helps to promote the method.

Testing Department of Qixian County People's Hospital of Henan Province, Hebi 456750, China

Online:2021-10-25 Published:2021-11-18

Abstract

Abstract: Objective:To study the value of combination detection of β2-microglobulin and neutrophil gelatinase-associated lipocalin(NGAL) in the diagnosis of early renal injury in children with infectious mononucleosis (IM).
Methods:Totally 85 children with IM were chosen, who were hospitalized for treatment from Jan. 2016 to Oct. 2019. They were divided into renal injury group(42 children，group A) and no-renal-injury group(43 children, group B). Forty healthy children receiving physical examination in our hospital in the same period were included as the healthy control group(group C). Compare the levels of urinary β2-microglobulin, NGAL, microalbumin/creatinine and NAG.
Results:The level of β2-microglobulin, NGAL, microalbumin/creatinine and NAG and the positive rate in group A were all higher than those in group B and group C, and the difference was statistically significant(P<0.05). There was no statistical difference between group B and group C(P<0.05).
Conclusion:The combination detection of β2-microglobulin, NGAL, microalbumin/creatinine and NAG is effective in the diagnosis of early renal injury in children with infectious mononucleosis. The samples are easy to obtain and the operation is simple, which helps to promote the method.

Key words: Infectious monondeosis, Early renal injury, β2-microglobulin, Child

NIU Zhenbing, LIU Jing, FENG Lili. Value of the combination detection of β2-microglobulin and neutrophil gelatinase-associated lipocalin in early renal injury in children with infectious mononucleosis[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(5): 399-401.

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Value of the combination detection of β2-microglobulin and neutrophil gelatinase-associated lipocalin in early renal injury in children with infectious mononucleosis

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