Abstract: Objective To explore whether the use of Reduning injection can improve the effectiveness and safety of the treatment for pediatric viral pneumonia by Meta-analysis.Methods Literatures on Reduning injection and pediatric viral pneumonia were searched in CNKI,VIP, Wanfang, CBM, PubMed and Embase databases, with the time limit from database construction to September 2021.Duplicate literature was excluded by Endnote X9 software; literature was screened according to the exclusion criteria,and data were extracted and quality evaluated.Data were recorded and Meta-analyzed using Stata 15.1 software.Finally, a sensitivity analysis was used to assess the outcome reliability.Funnel plots were used to evaluate the publication bias of the literature.Results A total of 21 literature articles were included, and the total sample size of the study was 2 632 cases.The results by Meta-analysis showed that the effective rate of test group was significantly higher than that of the control group with RR=1.13,95%CI(1.05,1.21).The incidence of adverse reactions in the test group was significantly lower than that in the control group, with RR=0.43,95%CI(0.29,0.64).Cough disappearance time［SMD=-2.73, 95%CI(-3.45, -2.00)］, lung rale disappearance time［SMD=-1.28, 95%CI(-1.40, -1.13)］,sore throat disappearance time［SMD=-1.26, 95%CI(-2.00, -0.52)］, X-ray chest ray shadow disappearance time［SMD=-2.38, 95%CI(-3.38, -0.88)］, time of fever relief［SMD=-2.14, 95%CI(-2.85, -1.43)］,and time of hospital stay［SMD=-1.97, 95%CI(-2.79, -1.14)］, in the test group were all better than those in the control group.Conclusion Reduning injection is very effective in the treatment of viral pneumonia in children,and can increase the effective rate and reduce the incidence of adverse reactions.

Key words: Viral pneumonia, Reduning injection, Meta-analysis, Child