Abstract:

Objective To analyze the changes of lung function and characteristics of exhaled nitric oxide in children with bronchial asthma and allergic rhinitis.Methods A retrospective analysis was performed in 85 children with mild to moderate acute episodes of bronchial asthma from September 2020 to February 2021 in the pediatric outpatient department of our hospital.According to the group of presence or absence of allergic rhinitis,the 85 children were divided into the bronchial asthma group and the group of asthma combined with rhinitis.According to whether children with asthma and rhinitis used nasal corticosteroids (NICS),the 47 children were divided into combined treatment group(n=28) and the group of inhalation of corticosteroids(ICS group,n=19).The lung function and FeNO were compared between bronchial asthma group and the group of asthma with rhinitis at acute stage.Compare the lung function and exhaled nitric oxide in the ICS treatment group and the combined treatment group after 3 months of treatment.Results (1)During the acute episode,there was no statistical difference in the following pulmonary function indexes：PEF%pred,FEV1%pred,FEV1/FVC%pred,FEF50%pred,FEF75%pred or MMEF%pred between the asthma combined with rhinitis group and the bronchial asthma group(P>0.05);FeNO in the asthma combined with rhinitis group was higher than that in the bronchial asthma group,and the difference was statistically significant(P<0.01).(2)After 3 months of treatment in children with asthma and rhinitis,FEF50%pred,FEF75%pred,and MMEF%pred in the combined treatment group were higher than those in the ICS treatment group,the difference being statistically significant(P<0.05);the FeNO value of the combined treatment group was lower than that of the ICS treatment group,and the difference was statistically significant(P<0.05).(3)In the asthma combined with rhinitis group,the level of FeNO was negatively correlated with FEF50%,FEF75% and MMEF% of small airway indicators of lung function during acute attack and at 3 months of treatment(P<0.05).Conclusion FeNO in children with bronchial asthma and allergic rhinitis is significantly increased,and combined treatment is more conducive to improving lung function and airway inflammation in children.

Key words:

Bronchial asthma, Allergic rhinitis, Lung function, Exhaled nitric oxide, ICS, Child