Table of Content

25 December 2020, Volume 12 Issue 6 Previous Issue    Next Issue

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Recognition of COVID-19 infection and characteristics of children's syndrome and treatment based on TCM theory WAN Ying，ZHAO Xiangyu 2020, 12 (6):  469.  Abstract ( 217 )   PDF (783KB) ( 97 )   Save The outbreak of COVID-19 infection has been worldwide and its clinical manifestations are complex and changeable.There is no effective medicine right now.China's measures to deal with the epidemic has demonstrated the characteristics and advantages of traditional Chinese medicine.There are various perspectives about the etiology, pathogenesis, treatment and prevention of the disease in TCM.There are many differences in clinical manifestations and disease evolution between children and adults.This article analyzes the novel coronavirus infection from the aspects of etiology, pathogenesis, disease location, disease nature and treatment based on the theory of TCM, and makes a comparative analysis of the special clinical manifestations of children. Related Articles | Metrics

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Professor Zhang Shiqing's experience in treating childhood epilepsy GAO LYu, LIU Lina,SHI Zhenggang,SHANG Jing,WU Liping 2020, 12 (6):  473.  Abstract ( 241 )   PDF (635KB) ( 77 )   Save Epilepsy is one of the common encephalopathies in children. Traditional Chinese medicine has obvious curative effect and advantages in treating epilepsy. This article mainly introduces Professor Zhang Shiqing's experience in treating infantile epilepsy with traditional Chinese medicine. According to the characteristics of epilepsy, Professor Zhang concluded that wind, phlegm and blood stasis are the key pathological factors for the occurrence and recurrent seizures of epilepsy. Phlegm and blood stasis obstruction and stagnation of brain orifices are the key pathogenesis for the occurrence and recurrent seizures of epilepsy. External wind-induced movement or internal liver wind-induced movement caused by body viscera imbalance are the important inducements for the occurrence and recurrent seizures of epilepsy. Based on wind-phlegm and stasis theory，the prescription of Pingxian granules is to promote blood circulation to remove blood stasis, reduce phlegm and prevent spasm, so as to prevent seizures. Related Articles | Metrics

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Meta-analysis of acupoint application therapy of "summer treatment for winter disease" for children with cough variant asthma LI Panpan，WU Liqun，XU Fangwei，WANG Dongsheng, LU Chen，HONG Jingyu. 2020, 12 (6):  477.  Abstract ( 140 )   PDF (3228KB) ( 49 )   Save Objective:To systematically evaluate the effectiveness of "summer treatment for winter disease" acupoint applications in the treatment of cough variant asthma(CVA) in children. Methods:Relevant studies of "summer treatment for winter disease" acupoint applications in the treatment of CVA in children were retrieved from electronic databases including China National Knowledge Infrastructure(CNKI), Wanfang database, Chongqing VIP information Chinese scientific journals database(VIP), Chinese Biomedical Literature database(CBM), PubMed, Cochrane Library and Embase database, from the inception to February 2020. Meta-analysis was conducted on the clinical trials selected according to the inclusion criteria. Results:In total, 10 randomized controlled trials(RCTs) involving 826 children were selected the meta-analysis. The analysis indicated that the use of acupoint applications in the treatment group was more effective than in the control group. In terms of the pulmonary function test and ACT scores, the forced expiratory volume in the first second(FEV1), forced expiratory volume in the first second/forced vital capacity(FEV1/FVC), peak expiratory flow rate(PEF) and ACT scores were better in the treatment group than in the control group, and the difference was statistically significant(P<0.05).In terms of immunoglobulins panel, IgM, IgG and IgA values in the treatment group were significantly higher than those in the control group, while IgE values of treatment group were significantly lower than those of the control group. Conclusion:The acupoint applications therapy of"summer treatment for winter disease" can increase the overall efficacy of treatment in children with CVA improve the pulmonary function, and regulate the body's immune status. Limited by the number and quality of included studies, large samples and high-quality studies are needed to further verify this conclusion. Related Articles | Metrics

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Research advances in the treatment of dysphagia in children with cerebral palsy YU Hengxi，LI Yin，XU Na，SHAN Exian，TAI Xiantao. 2020, 12 (6):  484.  Abstract ( 155 )   PDF (567KB) ( 65 )   Save To analyze the clinical research situation of dysphagia in children with cerebral palsy in the recent ten years，in order to provide reference for further optimizing the treatment plan and promoting the rehabilitation of children with cerebral palsy. A total of literatures were selected for analysis，induction and summary by searching the relevant documents of the four databases of CNKI，Wanfang，Weipu and Superstar in the recent ten years. In the treatment of dysphasia in children with cerebral palsy，two or more methods were used in combination in most cases，and the integrated treatment of traditional Chinese and western medicine has a significant effect，of which pediatric massage was safe and effective，simple and easy to operate with high compliance，so it was more suitable for children with cerebral palsy. Related Articles | Metrics

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Research progress in pathogenesis of primary enuresis in children ZENG Chuan，FANG Mingdong，SU Xiaolong，SUN Xiangjuan. 2020, 12 (6):  487.  Abstract ( 182 )   PDF (546KB) ( 52 )   Save The pathogenesis of primary enuresis is relatively complex. Currently，genetic factors，endocrine factors，bladder dysfunction，developmental retardation，nervous system dysplasia and mental factors are considered as the main research directions of the etiology of the disease. Based on the literatures related to the pathogenesis of primary enuresis in children in the databases, the pathogenesis is retrospectively reviewed, and the latest research progress in all levels is preliminarily summarized. After analysis, it is suggested that the pathogenesis of this disease tends to be multivariate, which provides the directions and lines of thinking for the research in making clinical comprehensive treatment plans. Related Articles | Metrics

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Treatment progress in Chinese and western medicine treatment for infectious mononucleosis in children SONG Meijun，SONG Zhe，ZHANG Heng，ZHANG Baoqing 2020, 12 (6):  492.  Abstract ( 205 )   PDF (760KB) ( 100 )   Save Infectious mononucleosis(IM) in children is mainly caused by EB virus. The disease is occult. The children are often in the state of carrying virus. The clinical manifestations of IM are various, likely to be a combined infection with a variety of pathogens. At present, western medicine treatment mainly starts with antiviral and symptomatic treatment, and new anti-EBV drugs are still developing; traditional Chinese medicine practitioners, by syndrome differentiation, base on traditional Chinese medicine theory and modern pharmacological research, have also achieved great success in the treatment of children's IM. This paper mainly describes the research progress in the Chinese and Western medicine treatment for infectious mononucleosis in children in recent years. Related Articles | Metrics

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Clinical application of Yinqiao Mabo powder in children CHEN Hongfei, SUN Xiangjuan, WU Lingyu. 2020, 12 (6):  496.  Abstract ( 214 )   PDF (550KB) ( 108 )   Save Yinqiao Mabo powder derives from Wu Jutong's book——Wenbing Tiaobian. It is a classic prescription in the treatment of throat diseases,used for dampness and warmness, and later it is also used for wind-heat and heat-toxin syndromes. The point is that pathogenic heat attacks the throat, so this prescription is widely used in the treatment of various diseases, and the effect is very good. This article makes a summary of the literatures concerning the clinical application of this prescription in acute tonsillitis, chronic pharyngitis, laryngeal cough, hand-foot-mouth disease, herpangina, myocarditis, hematuria and tic disorder, aiming to have a further understanding of the clinical application of Yinqiao Mabo powder in children. Related Articles | Metrics

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Effects of health education combined with anti-epileptic drugs on the level of serum cytokines and self-esteem in children with epilepsy based on a transtheoretical model SUN Xueyi,WANG Hongge,WANG Xufang,XU Ronghua 2020, 12 (6):  499.  Abstract ( 109 )   PDF (499KB) ( 62 )   Save Objective：To explore the effect of transtheoretical model based health education combined with antiepileptic drugs on serum cytokines and self-esteem levels in children with epilepsy. Methods：A total of 74 children newly diagnosed with epilepsy who were admitted to our hospital from February to October 2019 were selected as the research subjects and were randomly divided into control group and observation group with 37 cases each.Both groups were given antiepileptic drugs;the control group was given regular health education,and the observation group was given health education based on a transtheoretical model.After continuous intervention for 3 months,the serum cytokine levels and self-esteem levels of the two groups were observed. Results：The interleukin-2,interleukin-6 and tumor cytokine alpha of the observation group were lower than those of the control group,and the difference was statistically significant (P<0.05);the self-esteem scale score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05). Conclusion：Health education combined with anti-epileptic drugs based on a transtheoretical model can significantly improve the white blood cell level of children with newly diagnosed epilepsy,reduce serum cytokine levels,and improve self-esteem,which is of great significance to children′s early integration into society.  Related Articles | Metrics

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Effect of bilateral intensive training on gross motor function and walking function in children with spastic hemiplegia SHAO He，DU Xiubo，MA Bingxiang，LI Haifeng，CHANG Linlin，MI Xue 2020, 12 (6):  502.  Abstract ( 162 )   PDF (600KB) ( 45 )   Save Objective：To observe the effect of bilateral intensive training on gross motor function and walking function in children with spastic hemiplegia. Methods：The 30 children with spasmodic hemiplegia diagnosed and treated in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from Feb. 2014 to Dec. 2019 were randomly divided into control group(15 cases) and observation group(15 cases). Both groups received routine rehabilitation treatment, and bilateral intensive training was given to the observation group as exercise therapy; both groups were treated for 3 courses. The children were assessed before and after treatment by gross motor function scale assessment(GMFM-88), footprint analysis, 10-meter walk test and 1-minute walk test. Results：The scores in GMFM-88 test, step length, step width,10 m  walking time and 1 min walking distance in the two groups were better after treatment than before treatment(P<0.05), and the observation group was better than the control group(P<0.05). Conclusion：Bilateral intensive training combined with conventional rehabilitation can improve the gross motor function, correct abnormal gait, and increase walking speed, endurance and stability of children with spastic hemiplegia. Related Articles | Metrics

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Establishment of prediction model of recurrent wheezing after multifactor bronchiolitis TONG Zhijie,HUANG Jianjun,WU Peiqiong. 2020, 12 (6):  506.  Abstract ( 164 )   PDF (643KB) ( 55 )   Save Objective：To explore the establishment of a predictive model for recurrent wheezing after multifactor bronchiolitis. Methods：Totally 91 patients with multifactor bronchiolitis admitted to our hospital from May 2016 to February 2019 were selected.All the patients were followed up for one year after discharge.The patients were divided into two groups based on occurrence of wheezing after follow-up:repeated wheezing group(n=41) and nonwheezing group(n=50).General clinical data of the two groups were collected.Logistic regression was used to construct a combined detection factor model of repeated wheezing in children with bronchiolitis.The receiver operating characteristic curve(ROC) was drawn. Results：The proportion of tobacco contact history,lung texture thickening,eczema milk protein positive and no supplementation of vitamin A and D in the repeated wheezing group was higher than that in the non-wheezing group(P<0.05).Logistic regression analysis showed that tobacco contact history(OR=10.145,95%CI=1.541～20.728),supplementation of vitamin A and D(OR=5.652,95%CI=1.541～20.728),eczema (OR=1.370,95%CI=1.089～1.723),and milk protein(OR=1.711,95%CI=1.079～2.712) were independent risk factors for recurrent wheezing in children with bronchiolitis.The expression of joint detection factor model was:Logit（P）=-4.751＋2.317X1＋1.732X2＋0.315X3＋0.537X4.The best critical value of the combined detection factor model was 0.457,the sensitivity was 89.47%,the specificity was 86.79%,and the area under the curve was 0.852(0.651～0.977). Conclusion：Multifactor comprehensive construction combined detection factor model for children with bronchiolitis can better predict the occurrence of repeated wheezing. Related Articles | Metrics

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Analysis of the influencing factors of neurodevelopmental disorder after brain white matter injury in late preterm infants LI Xin，LI Tong 2020, 12 (6):  511.  Abstract ( 144 )   PDF (493KB) ( 35 )   Save Objective：Based on the magnetic resonance manifestations and clinical characteristics of brain white matter injury in late preterm infants(LPIs), to evaluate their mental development and psychomotor development, and to discuss the effects of different degrees of white matter injury on the neurological development of late preterm infants. Methods：From February 15,2013 to March 12,2018,139 late preterm infants accepted MRI examination at 8-14 days after birth in Shenyang Women and Children's Hospital.Totally,114 LPIs were followed up at one year old, and their mental development index(MDI) and psychomotor development index(PDI) were measured, which were used to evaluate the neurological development of these children. Results：In the 114 late preterm infants, those with mental dysfunction and psychomotor dysfunction had significantly lower average gestational age, birth body mass and l min Apgar score than the children with normal mental and psychomotor development; the time for taking low flow oxygen was significantly prolonged, and there was statistical difference(P<0.05). The more severe the brain white matter injury and the higher the degree of ventriculomegaly, the more likely the mental and psychomotor dysfunction in these children. Conclusion：The more severe the brain white matter injury and the ventriculomegaly in the late preterm infants, the poorer the outcome of neurological development.The more severe the brain white matter injury and the ventriculomegaly in the late preterm infants, the poorer the outcome of neurological development. Related Articles | Metrics

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Effect of nutritional support based on STRONGkids nutritional risk screening on nutritional status and clinical outcome of children after general surgery WANG Ranran，LI Na 2020, 12 (6):  515.  Abstract ( 138 )   PDF (441KB) ( 65 )   Save Objective：To explore the effect of nutritional support based on screening tool for risk on nutritional status and growth (STRONGkids) on nutritional status and clinical outcome of children after general surgery. Methods：A total of 131 postoperative children receiving operations in our department from June 2018 to December 2019 were selected as the research subjects, and they were divided into 65 cases in the control group and 66 cases in the observation group using a random number table method. The control group was given routine nutritional management after the operation; the observation group was given the nutritional support of STRONGkids nutritional risk screening after the operation, and the intervention effects were compared. Results：The levels of albumin (Albumin, Alb) and prealbumin(Prealbumin, PA) in the observation group were significantly higher than those in the control group at 7 days after surgery and at the time of discharge(P<0.05); the infection rate of parenteral nutrition(PN)-related catheters in the observation group was lower than that in the control group(P<0.05); the postoperative incision infection rate was significantly lower in observation group than in the control group(P<0.05); the incidence of anastomotic leakage was lower in observation group than in the control group(P<0.05). Conclusion：Nutrition support of STRONGkids nutritional risk screening can improve the nutritional status and clinical outcome of postoperative children in general surgery department. Related Articles | Metrics

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Analysis of the characteristics of amplitude integrated EEG at early stage after birth in preterm infants of different gestational ages WEI Enhuan，YANG Hui，LIN Huixiang. 2020, 12 (6):  518.  Abstract ( 101 )   PDF (441KB) ( 54 )   Save Objective：To investigate the characteristics of amplitude integrated electroencephalogram(aEEG) at early stage after birth in preterm infants of different gestational ages(GA). Methods：From January 2014 to December 2016, 209 preterm infants of different gestational ages were treated in the First Affiliated Hospital of Sanming of Fujian Medical University, who were divided into 6 groups according to the gestational age. NicoletOne brain function monitor was used to monitor the changes of aEEG within 24 hours after birth. The aEEG background continuity,sleepingwaking cycle, lower boundary voltage amplitude and bandwidth of the narrow band were retrospectively analyzed to study the regularity of the changes. Results：The aEEG wave form continuity of 209 preterm infants showed that: (1)In the group with GA<28 weeks, all of them were highly discontinuous,and with the increase of GA, the proportion of continuous voltage gradually increased. There was significant difference among the groups(P<0.01). (2)There was no noticeable changes in the sleep cycle in the group with GA<28 weeks. With the increase of GA, the frequency of sleep cycle gradually increased and matured, and there was a significant difference among the GA groups(P<0.01). (3) With the increase of GA, the amplitude of the lower boundary of the spectral band increased. The difference in the amplitude of the lower boundary among the groups of preterm infants was statistically significant(P<0.01); the bandwidth tended to become narrow. The difference among the groups of preterm infants was statistically significant(P<0.01). Conclusion：The aEEG shows some specific regularity at different GA in preterm infants，which provides a certain reference for clinical judgment of brain function in premature infants. Related Articles | Metrics

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Analysis of the clinical value of ultrasonography in the early diagnosis of pediatric hip dysplasia ZHOU Meixia，ZHOU Hao. 2020, 12 (6):  521.  Abstract ( 181 )   PDF (399KB) ( 64 )   Save Objective：To explore the clinical value of ultrasonography in the early diagnosis of pediatric hip dysplasia. Methods：A total of 158 children with suspected DDH admitted to our hospital from June 2018 to December 2019 were selected as the research subjects, and they were randomly divided into observation group and control group with 79 cases each. The control group was given X-ray examination, and the observation group was given high-frequency ultrasound examination. Results：The diagnosis rate of high-frequency ultrasound in the observation group was the closest to the clinical diagnosis rate, and the difference was not statistically significant (P<0.05); the X-ray diagnosis rate of the control group was 64.56%(51/79), which was significantly lower than the clinical diagnosis rate(96.20%,76/79), and the difference is statistically significant(P<0.05). Conclusion：The high-frequency color Doppler ultrasound has high clinical application value in the diagnosis of pediatric DDH, with clear diagnostic criteria and relatively mature and stable technology.  Related Articles | Metrics

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Analysis of lymphocyte subsets in peripheral blood of children with early stage of post-infectious bronchiolitis obliterans LI Linrui，ZHANG Xi，CHEN Yanping. 2020, 12 (6):  524.  Abstract ( 92 )   PDF (426KB) ( 55 )   Save Objective：To investigate the significance of lymphocyte subsets changes in peripheral blood for early identification of children with post-infectious bronchiolitis obliterans(BO). Methods：Forty-eight children admitted to Hunan Children's Hospital from June 2016 to June 2018, who were diagnosed with severe pneumonia at the initial stage of admission, were selected;the 24 cases of BO confirmed after adenovirus infection were in the observation group, and 24 children with severe pneumonia that did not progress to BO in the same period were selected as the control group.The lymphocyte subsets in both groups were determined by flow cytometry upon admission diagnosis of severe pneumonia. Results：There was no significant difference in the number or ratio of total T lymphocytes and total B lymphocytes between the two groups(P<0.05).The number and ratio of CD4 cells in the observation group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05).There was no statistically significant difference in the number of CD8 cells between the two groups(P<0.05), but the ratio of CD8 cells in the observation group was higher than that in the control group(P<0.05).The number and ratio of natural killer (NK) cells in the observation group were lower than those in the control group, and the difference was statistically significant(P<0.05).The difference in CD4/CD8 ratio between the two groups was statistically significant(P<0.05). Conclusion：The number and ratio of CD4 and NK cells in children with severe pneumonia of secondary postinfectious BO may be used as indicators for early identification of BO. Related Articles | Metrics

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Clinical characteristics of children with Henoch-Sehonlein purpura of abdominal type and the application value of endoscopic diagnosis under narrow band imaging LI Jiuying,LI Pingzhen,QIU Yaming 2020, 12 (6):  527.  Abstract ( 83 )   PDF (470KB) ( 27 )   Save Objective:To analyze the clinical characteristics of children with Henoch-Sehonlein purpura(HSP) of abdominal type and the application value of NBI endoscopy in the diagnosis and treatment of HSP of abdominal type. Methods:Seventy children with suspected HSP of abdominal type who were admitted to the hospital between May 2016 and May 2019 were selected as the subjects. They were examined with abdominal B ultrasound and NBI endoscopy. The clinical characteristics of children with HSP were summarized. Based on the pathological diagnosis results, the diagnosis rates of HSP of abdominal type by the two examination methods were compared. The application value of NBI endoscopy in the clinical diagnosis of children with HSP of abdominal type was analyzed. Results:In this study, all subjects had different degrees of abdominal pain, with or without paroxysmal exacerbation. The pain was not fixed, but was mainly around the navel, and all children had symptoms of skin purpura in the course of the disease. The diagnostic sensitivity, specificity and accuracy of NBI endoscopy for HSP of abdominal type were 95.24%(60/63), 71.43%(5/7) and 92.86%(65/70), respectively. Compared with 79.25%(42/53), 29.41%(5/17) and 67.14%(47/70) by abdominal B ultrasound examination, the differences in sensitivity and accuracy were significant (P<0.05). Conclusion:There are no specific gastrointestinal symptoms in children with HSP of abdominal type. The diagnostic sensitivity and accuracy of NBI endoscopy in children with HSP of abdominal type are high, which can provide a reliable basis for the clinical diagnosis and treatment of children with HSP and the clinical application value is high. Related Articles | Metrics

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Clinical observation of Ginseng-Schisandrae decoction combined with azithromycin in the treatment of children with lobar pneumonia caused by mycoplasma infection MAO Qingdong 2020, 12 (6):  530.  Abstract ( 360 )   PDF (610KB) ( 46 )   Save Objective：To observe the clinical efficacy of Ginseng-Schisandrae decoction combined with intravenous azithromycin in the treatment of children with lobar pneumonia caused by mycoplasma infection (syndrome of qi deficiency of lung and spleen). Methods：From January to December 2019,90 cases of lobar pneumonia (syndrome of qi deficiency of lung and spleen) caused by mycoplasma infection admitted to Pediatric Department in Wuhu Traditional Chinese Medicine Hospital were divided into treatment group and control group according to random number table method, with 45 cases in each group. Both groups were treated with azithromycin for anti-infection and symptomatic treatment, and the observation group was also treated with Ginseng-Schisandrae decoction. After 1 week of treatment, the clinical symptoms, signs and hospitalization time of the two groups were compared. The improvement in the scores of TCM syndrome of qi deficiency of lung and spleen before and after treatment,the improvement in serum inflammatory indicators(white blood cell count, neutrophils, C-reactive protein) before and after treatment,and the occurrence of adverse reactions were compared, and the clinical efficacy of the two groups were counted. Results：After treatment, the clinical symptoms, signs and hospitalization time in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05).The scores of primary and secondary symptoms of syndrome of qi deficiency of lung and spleen in the two groups were lower after treatment than before treatment, and those in the observation group were lower than those in the control group, with statistically significant differences(P<0.05).The serum inflammatory indicators (white blood cell count, neutrophils, C-reactive protein) of the two groups after treatment were all lower than those before treatment, and the serum inflammatory indicators of the observation group were all lower than those of the control group, with statistically significant differences(P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion：For the children with lobar pneumonia caused by mycoplasma infection (syndrome of qi deficiency of lung and spleen), giving Ginseng-Schisandrae decoction on the basis of intravenous azithromycin treatment can significantly improve clinical symptoms and signs, shorten the length of hospital stay, reduce inflammatory reactions and reduce the use of antibiotics, and It is safer. Related Articles | Metrics

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Predictors of severe adenovirus pneumonia in children KANG Xiaojun，SUI Xiaodong，ZHUO Zhiqiang 2020, 12 (6):  534.  Abstract ( 199 )   PDF (438KB) ( 70 )   Save Objective：To investigate the predictors of severe adenovirus pneumonia（SAP）in children. Methods：The clinical data of 200 children with SAP were retrospectively analyzed. Logistic regression analysis was performed to assess the predictors of SAP in children. Results：The univariate Logistic regression analysis showed that the lower the levels of HB, cholinesterase and plasma albumin, the higher the AST and LDH, and when combined with mycoplasma infection, adenovirus pneumonia was more likely to occur in children(P<0.05). Conclusion：Indicators such as HB, cholinesterase, albumin, AST, LDH and combination with MP infection have predictive value for SAP in children. Related Articles | Metrics

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Clinical effect of Huangqi Guizhi Wuwu decoction and Zhizhujiang decoction in the treatment of constipation in children HU Yingjie,HAN Xue, SUN Fengping 2020, 12 (6):  537.  Abstract ( 267 )   PDF (474KB) ( 26 )   Save Objective：To observe the clinical effect of Huangqi Guizhi Wuwu decoction and Zhizhujiang decoction in the treatment of constipation in children with weakness of the spleen and stomach. Methods：A total of 80 children with constipation were selected, who were treated in the outpatient department of Henan Children's Hospital from Sep. 2017 to Oct. 2018, and they were divided into control group and observation group, 40 in each group. The control group was given lactulose oral liquid, and the observation group received Huangqi Guizhi Wuwu decoction and Zhizhujiang decoction with addition of some medicinal herbs; the treatment lasted for two weeks as a course. After treatment, the changes in clinical total effective rate and TCM symptom score were compared between the two groups. Results：The clinical total effective rate of observation group was 87.5%(35/40), significantly higher than that of control group(67.5%,27/40), and the difference was of statistical significance(P<0.05).The major symptom score, minor symptom score and the total score of observation group were significantly reduced after treatment, and compared with those of control group, there was statistical differencee(P<0.05). Conclusion：Huangqi Guizhi Wuwu decotion and Zhizhujiang decoction with addition of some medicinal herbs can effectively improve the clinical symptoms of constipation in children with weakness of spleen and stomach and increase the clinical effect, which has some clinical application value.  Related Articles | Metrics

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Efficacy and safety analysis of self-prepared Xunjing Zhijing decoction in children with tic disorder DAI Weifeng，HAN Xue 2020, 12 (6):  541.  Abstract ( 119 )   PDF (539KB) ( 55 )   Save Objective：To study the efficacy and safety of self-made Xunjing Zhijing decoction in children with tic disorder. Methods：A total of 142 children with tic who were treated in our hospital from February 2018 to February 2019 were selected as observation subjects, and they were randomly divided into observation group and control group with 71 cases each. The control group was treated with haloperidol, auricular acupoint sticking and acupuncture, and the observation group was additionally treated with Xunjing Zhijing decoction on this basis. The treatment duration was 6 months. The efficacy, Yale tic overall severity scale(YGTSS) score and side effects were compared between the two groups. Results：The total clinical effective rate was 97.18%(69/71) in the observation group, which was significantly higher than that in the control group(88.73%,63/71), and the difference was statistically significant（P<0.05）.After treatment, the YGTSS scores of both groups were significantly lower than before treatment, and the observation group was lower than the control group, the difference being statistically significant（P<0.05）.The total incidence of side effects was 5.63%(4/71) in the observation group, which was significantly lower than 16.90%(12/71) in the control group, and the difference was statistically significant(P<0.05). Conclusion：The efficacy and safety of Xunjing Zhijing decoction are good, and it can also effectively improve the YGTSS score of children, which is worthy of promotion. Related Articles | Metrics

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Analysis of Du Ping's experience in treating children with recurrent respiratory tract infection with herbal paste MA Chuanzhen，WEN Yuling，WANG Jia 2020, 12 (6):  544.  Abstract ( 97 )   PDF (571KB) ( 52 )   Save Director Du Ping is the guiding teacher for the sixth batch of old Chinese medicine experts to inherit academic experience. Director Du Ping has been engaged in pediatric clinical work for more than 30 years and has rich clinical experience. She is good at treating children with recurrent respiratory tract infection with herbal paste. According to the physiological and pathological characteristics of children, she has summarized that the key pathogenesis of recurrent respiratory tract infection in children is the deficiency of vital energy and imbalance of yin and yang. Based on the physical characteristics of contemporary children, the herbal paste is used to regulate the qi, blood, yin and yang of children in order to prevent recurrent respiratory tract infection in them. Related Articles | Metrics

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A Meta-analysis of the clinical efficacy of the treatment for infantile pneumonia with modified Maxing Shigan decoction LIU Ziwei，XIE Linchen，CHU Hang，QIN Wen，LI Da 2020, 12 (6):  547.  Abstract ( 224 )   PDF (1574KB) ( 44 )   Save Objective:To perform a Meta-analysis by observing the clinical efficacy of the treatment for infantile pneumonia with modified Maxing Shigan decoction. Methods:The Chinese biomedical literature database(CBM), Chinese academic journal full-text database(CNKI), Wanfang database, Weipu database and PubMed were searched by computer to collect the randomized controlled trialsconcerning the treatment for infantile pneumonia with the modified traditional Chinese medicine prescriptions including Maxing Shigan decoction. The quality of included literature was evaluated by Cochrane systematic evaluation method, and the Meta-analysis of included literature was made by Revman 5.3 statistical software. Results:A total of 13 randomized controlled trials were included, involving 657 patients. The Meta-analysis results showed that the total effective rate of the treatment for infantile pneumonia with Chinese medicine prescription including modified Maxing Shigan decoction was better than that of western medicine, and the combined OR value was 2.31［95%CI(1.82,2.93)］. Conclusion:Compared with western medicine, the clinical efficacy of Chinese medicine prescriptionsincluding modified Maxing Shigan decoction in the treatment of acute pneumonia in children has certain advantages, and it has provided a reference basis for the promotion of novel coronavirus in the global treatment scheme. Related Articles | Metrics

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Observation on the therapeutic effect of Qinlian Zhixie decoction on chronic diarrhea in children ZHANG Yan，TANG Hong 2020, 12 (6):  551.  Abstract ( 109 )   PDF (577KB) ( 48 )   Save Objective：To evaluate the effect of Qinlian Zhixie decoction in the clinical treatment of chronic diarrhea in children. Methods：Totally 76 children with chronic diarrhea admitted to our hospital from March 2019 to January 2020 were randomly divided into two groups: the control group(38 cases) was treated with conventional western medicine，while the observation group(38 cases) was treated with Qinlian Zhixie decoction in addition to western medicine，and the inflammation control，immune function improvement and symptom improvement were observed. Results：The levels of IL-6， IL-10 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05) after treatment; after treatment, CD8+ in the observation group was lower than that in the control group，while IgA，IgG and CD4+，CD4+/CD8+ were higher than that in the control group(P<0.05);after treatment，the TCM symptom score and total score of the observation group were lower than those of the control group，the difference being statistically significant(P<0.05). The total effective rates of the two groups were 94.74%(36/38) and 78.95%(30/38)，respectively(P<0.05). Conclusion：On the basis of conventional symptomatic treatment and western medicine treatment，Qinlian Zhixie decoction, when used to treat patients with chronic diarrhea，can effectively improve the effect of inflammation control，better regulate the immune function of children，and help to improve the overall treatment effect. Related Articles | Metrics

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Clinical efficacy observation of pediatric massage as an adjuvant treatment for bronchopneumonia LI Liyang，SUN Xiaoxu 2020, 12 (6):  555.  Abstract ( 153 )   PDF (676KB) ( 35 )   Save Objective：To explore the effect of pediatric massage as an adjuvant treatment on the prognosis of children withbronchopneumonia. Methods：Select 40 children with bronchopneumonia who received pediatric massage in our hospital between November 2019 and January 2020 as the observation group.Another 40 children with pronchopneumonia who did not receive pediatric massage as adjuvant treatment in the same period were selected as the control group.Compare the differences between the two groups in terms of clinical efficacy, relief time of main symptoms and signs, length of clinical antibiotic use, and incidence of adverse reactions during the treatment cycle. Results：The clinical cure rate and total effective rate of the observation group were 80.0%(32/40) and 95.0%(38/40) respectively ,significantly higher than those of the control group［52.5%（21/40）、77.5%（31/40）］,and the difference was statistically significant（P<0.05）.The observation group had shorter than the control group in terms of body temperature returning to normal, cough relief, asthma relief and disappearance of lung rales,the difference being statistically significant（P<0.05）.The number of children in the observation group who used clinical antibiotics for 5 days was significantly higher than that in the control group, and the number of cases who used for 7 days and above was significantly lower than that of the control group,the difference being statistically significant（P<0.05）.The adverse reaction rate of children in the observation group was 5.0%(2/40),significantly lower than that of the control group(20.0%,8/40),the difference being statistically significant（P<0.05）. Conclusion：Adjuvant massage for children with bronchial pneumonia can effectively improve the clinical therapeutic effect，shorten the use time of clinical antibiotics and reduce the incidence of adverse reactions. Related Articles | Metrics

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Analysis of Ni Juxiu's experience in treating spasmodic cough of pertussis in children SUN Ting, SHEN Jiaying, HAN Haiqiong 2020, 12 (6):  559.  Abstract ( 134 )   PDF (601KB) ( 84 )   Save Director Ni Juxiu, based on her longterm accumulation of clinical experience, has come to the belief that the etiology and pathogenesis of pertussis in children are the exogenous disease inducing phlegm, which interact with each other, resulting in the blocking of air tube. The differentiated treatment is adopted, and the treatment of spasmodic cough is especially important. The treatment should focus on the cause of the disease instead of the symptoms, and the phlegmheat is the main cause in spasmodic cough; therefore, the treatment aims to relieve lung and remove phlegm, and San'ao decoction and Zhike powder with modification are used in clinical treatment. In addition, acupunction and point application are used as external therapy, which has achieved significant effect and greatly shortens the disease course. Related Articles | Metrics

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Clinical observation on the treatment for spasmodic cerebral palsy with Chinese herb bathing and wax therapy of the lower limbs SHEN Yan'e 2020, 12 (6):  562.  Abstract ( 210 )   PDF (501KB) ( 47 )   Save Objective：To investigate the clinical effect of lower limb herb bathing combined with wax therapy for spastic cerebral palsy. Methods：Sixty cerebral palsy children with spastic quadriplegia and diplegia, who were treated in Shenyang Children's Hospital from June 2017 to June 2019, were included as the research subjects, and they were randomly divided into control group(n=30) and observation group(n=30). Both groups received comprehensive rehabilitation training and wax therapy, and the observation group received additional lower limb herb bathing. Both groups were treated for 90 days as a course, for 2 courses. The effect was evaluated by gross motor function measurement(GMFM-88) before treatment, and at the end of one and two courses respectively. Results：The GMFM:-88 score was increased after treatment in both groups, and it was higher in observation group than in control group after one course and two courses of treatment(P<0.05). The total effective rate and the rate of obvious effect were both higher in observation group than in control group(P<0.05). Conclusion：In the treatment of spastic cerebral palsy, the combination of conventional rehabilitation training with lower limb herb bathing and wax therapy, which is the combination of traditional Chinese therapy with the modern rehabilitation treatment, has significant clinical effect. Related Articles | Metrics

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Clinical efficacy of chiropractic combined with abdominal massage for feeding intolerance in premature infants CHANG Xia, WANG Li, FENG Xiufang, HOU Guoqiang, YANG Miao 2020, 12 (6):  565.  Abstract ( 113 )   PDF (470KB) ( 41 )   Save Objective:To observe the clinical effect of chiropractic combined with abdominal massage for feeding intolerance of premature infants. Methods:A total of 80 premature infants hospitalized in the Neonatal Department of our hospital from March 2019 to February 2020 were randomly divided into a control group(n=40) and treatment group(n=40).The control group was given micro-feeding of breast milk or formula milk for preterm infants, and parenteral intravenous nutrition was added according to the nutritional recommendations for premature infants. The treatment group was given chiropractic and abdominal massage in addition to the treatment for the control group. After one-week treatment，the following indexes were observed: the symptom score, milk volume, enteral nutrition calorie, weight at 3 days after treatment, weight difference and the time reaching full feeding. Results:The weight of the infants had no statistical difference between the control group and the treatment group after treatment(P<0.05); the difference in body weight before and after treatment, milk volume, and enteral nutrition calories in the treatment group were higher than those in the control group, while the time reaching full feeding was lower，and the difference is significantly statistical(P<0.05).After treatment, the symptom score in treatment group was significantly lower than that in control group, the difference being statistical(P<0.05). Conclusion:Chiropractic combined with abdominal massage can regulate the spleen and stomach to treat feeding intolerance in premature infants, which can reduce vomiting and promote the recovery of enteral nutrition. The effect is good. Related Articles | Metrics