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Observation on the effect of Weijing Ditan decoction in the treatment of children with protracted bacterial bronchitis WANG Shengnan, WANG Guojie, WANG Hai Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 281-.   Abstract （657）      PDF（pc） （544KB）（28）       Knowledge map    Save Objective:To observe the therapeutic effect of self-made Weijing Ditan decoction on children with protracted bacterial bronchitis. Methods:From March 2017 to March 2018，82 children with protracted bacterial bronchitis were treated in the First Affiliated Hospital of Heilongjiang TCM University, and they were randomly divided into experimental group(42 cases) and control group(40 cases). The experimental group was treated withWeijing Ditan decoction，while the control group was treated with ambroxol hydrochloride oral solution combined with amoxicillin and clavulanate potassium, for 3 weeks. The effective indexes were cough symptom score， TCM syndrome score and lung CT abnormality score. Results:After 3 weeks of treatment，the total effective rate of the experimental group was 88.1%(37/42)， which was significantly higher than that of the control group (70.0％，28/40) (P<0.05).After treatment， the cough symptom score， the primary andsecondary symptom scores of Tanzhuoyunfei and Feishixuanjiang syndrome of the two groups were significantly lower than thosebefore treatment (P<0.05)， and the reduction effect of the experimental group was significantly better than that of the control group，the differences being statistically significant(P<0.05). After treatment， among the 17 cases of obstructive ventilation disorder，16 cases turned to normal after 3 weeks of treatment，and 1 case turned to moderate after 2 weeks of treatment.After treatment， the CT severity scores of 17 cases in the experimental group and 14 cases in the control group were significantly reduced compared with those before treatment，and the influenceof CT in experimental group was more significantly reduced(P<0.05). Conclusion:Weijing Ditan decoction in the treatment of children with protracted bacterial bronchitis can significantly improvecough symptoms and TCM syndromes， and significantly improve pulmonary ventilation function and HRCT performance. Related Articles | Metrics

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Construction of Atg7-gene-knockout human brain microvascular endothelial cell line based on CRISPR/cas9 technology LI Wenhui, LIU Hui, LI Zeye, WEI Jiayi, CHEN Yuhua Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 286-.   Abstract （603）      PDF（pc） （1826KB）（44）       Knowledge map    Save Objective:To construct Atg7-gene-knockout human brain microvascular endothelial cells(HBMEC) by CRISPR/cas9 technology, so as to provide an in vitro cell model for the role of Atg7 in the development of cerebral vessels, the mechanism of Atg7 participating in the formation of blood-brain barrier and thestudy of cerebrovascular diseases. Methods:Two pairs of guiding RNA sequences(sgRNA) were designed according to exon 1 of human Atg7. HBMEC was transfected with lentivirus; puromycin and Pyricularia oryzae were used to screen for cells successfully transfected. RT-qPCR and Western blotting were used to detect the mRNA and protein of the target gene, and the morphological changes were observed under the microscope. Results:The CRISPR/cas9 plasmid targeting Atg7 was constructed. The results of RT-qPCR, Western blot and immunofluorescence showed that stable Atg7-knockout human brain microvascular endothelial cell line was  obtained by monoclonal screening. No obvious morphological changes were observed under light microscope. Conclusion:The successful construction of human brain microvascular endothelial cells with Atg7 gene knockout by CRISPR/cas9 technology is beneficial to the development of cerebral vessels, the mechanism of blood-brain barrier morphogenesis and the study of cerebrovascular diseases. Related Articles | Metrics

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Research progress in clinical application of Huaiqihuang granules in pediatrics HAN Jing, XU Yan, SUN Liping Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 292-.   Abstract （555）      PDF（pc） （718KB）（30）       Knowledge map    Save Huaiqihuang granules is a Chinese patent medicine commonly used in modern pediatric clinic, which is composed of bacterial substance of Sophora japonica, wolfberry fruit and polygonatum. It has the effect of comprehensiveregulation and nourishment on the human body, and is widely used in pediatric clinic. This paper reviewsthe research progress in the clinical application of Huaiqihuang granules in pediatric department in recent years, which shows that there have been more and more researches in Huaiqihuang granules, but there is a lack of large-sample multicenter research and real-world research, and there is less research in its application safety, so the treatmenteffect of Huaiqihuang granules on different types of various diseases needs to be further and carefully studied. With the deepening of experimental research, especially the application of cytobiological and molecular biological technology, the functional mechanism and clinical application of Huaiqihuang granules should be further investigated. Related Articles | Metrics

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Yangyin Qingfei mixture in the treatment of cough(yin-deficiency and lung-heat syndrome) after mycoplasma infection in children:a clinical observation SONG Lichao, WANG Xuefeng, GUAN Xuefeng, ZHANG Xiuying, LIU Yue Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (3): 253-255.   Abstract （489）      PDF（pc） （375KB）（41）       Knowledge map    Save Objective: To observe the effect of Yangyin Qingfei mixture on cough (yin-deficiency and lung-heat syndrome) after Mycoplasma pneumoniae infection. Methods: From January 2018 to June 2020,120 children with cough after mycoplasma infection (yin-deficiency and lung-heat syndrome) in Pediatric Outpatient Department and ward of Affiliated Hospital of Liaoning Universityof Traditional Chinese Medicine were randomly divided into two groups,60 cases in the treatment group and 60 cases in the control group.The control group was treated with western medicine.The treatment group was given YangyinQingfei mixture on the basis of western medicine.Both groups were treated for 7 days continuously,and the effect was observed. Results: After treatment,the scores in cough,dry stool,feverishness in palms and soles and night sweating and the total scores were significantly lower in observation group than in control group(P<0.05).After treatment,the total effectiveness in observation group was better than that in control group(P<0.05).After treatment,the effective rate in observation group was 96.67% (58/60),which was higher than in the control group (81.67%,49/60)(P<0.05). Conclusion: Yangyin Qingfei mixture has a significant effect on cough (yin-deficiency and lung-heat syndrome) after mycoplasma infection in children. Related Articles | Metrics

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Effects of modified Jiegeng decoction on children with allergic rhinitis with underlying heat in lung meridian SUN Xiangjuan, LIU Li, WENG Dongbo, YU Qiuxiang, ZHANG Fenghua Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 350-.   Abstract （457）      PDF（pc） （488KB）（15）       Knowledge map    Save Objective: To observe the clinical efficacy of modified Jiegeng decoction in the treatment of allergic rhinitis in children with underlyingheat of lung meridian. Methods: Totally 101 children with allergic rhinitis treated in the pediatric clinic of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January to December 2019 were randomly divided into 52 cases in the observation group and 49 cases in the control group. The observation group was treated with modified Jiegeng decoction, and the control group was treated with Loratadine Tablets for 3 weeks, respectively. Then, the efficacy and safety for the two groups were preliminarily evaluated. Results: After 3 weeks of treatment, the effective rate for rhinitis in the observation group was 92.3% (48/52), which was significantly higher than 61.2%(30/49) in the control group(P<0.05); the effective rate for the syndrome of underlying heat in lung meridian in the observation group was 92.3%(48/52), which was significantly higher than 79.6%(39/49) in the control group(P<0.05). The scores in sneezing, nasalcongestion, runny nose, nasal itching, nasal mucosal swelling, pharyngeal dryness, pharyngeal itching and pharyngeal redness in the observation group were lower than those in the control group(P<0.05). There were no adverse reactions in the two groups. Conclusion: After the treatment of modified Jiegengdecoction, the condition of children with allergic rhinitis has been significantly improved, and the clinical effect is significant and safe. Related Articles | Metrics

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Comparative analysis of cranial CT and magnetic resonance imaging in the evaluation of brain injury in children with hyperbilirubinemia CHEN Yizhou, HUANG Yuxin, MA Chunnong Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 340-.   Abstract （373）      PDF（pc） （599KB）（13）       Knowledge map    Save Objective:To observe the diagnosis and evaluation of brain injury in children with hyperbilirubinemia by brain CT and magnetic resonance imaging(MRI). Methods:A total of 63 children with hyperbilirubinemia treated in our hospital from February 2019 to April 2020 were selected as the observation group; 50 healthy newborns in the same period were selected as the control group. The NBNA score and TB level were determined; the brain CT and MRI techniques were used and the evaluation results of brain injury in children with different methods were analyzed. The measurement of brainstem auditory evoked potential was the gold standard. Results: The TB level in the observation group was significantly higher than that in the control group, while the NBNA score was lower(P<0.05). Comparing the diagnostic results of the two methods, the accuracy andsensitivity of MRI were higher than those of CT(P<0.05). The incidence of hyperbilirubinemia within 3 days in children with positive cranial MRI was 79.41%(27/34), which was higher than 17.24%(5/29) in children with negative cranial MRI(P<0.05); the NBNA score of positive children was (32.50±1.36), which was lower than that of negative children (34.14±1.40) (P<0.05). The cost-effectiveness ratio of brain MRI technology is lower thanthat of brain CT technology, and the economic benefit of MRI technology is higher. Conclusion: Compared with cranialCT, MRI has higher accuracy and sensitivity in the diagnosisof hyperbilirubinemia in children, and combined with NBNA score, it can be used as an important method for early evaluation of brain injury in children. Related Articles | Metrics

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Correlation analysis of serum albumin with liver function and coagulation function in children with NICCD PAN Wangui, LIN Yihui, JIANG Fuliang Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 336-.   Abstract （364）      PDF（pc） （489KB）（6）       Knowledge map    Save Objective:To analyze the correlation between serum albumin(ALB) and liver function and coagulation function in childrenwith intrahepatic cholestasis(NICCD). Methods:The clinical data of 56 children with NICCD treated in our hospital between March 2017 and March 2020 were retrospectively analyzed. Based on the level of serum ALB, these children weredivided into low-ALB group(ALB<30 g/L)(26 cases) and normal-ALB group (ALB≥30 g/L)(30 cases). Compare the differences in the degree of subcostal hepatomegaly and the coagulation indexes［(activatedpartial thromboplastin time(APTT), prothrombin time(PT), thrombin time(TT) and fibrinogen(FIB)］. Spearman correlation analysis method was used to analyze the correlation of the level of serum ALB with the degree of subcostal hepatomegaly and coagulation indexes in children with NICCD. Based on the prognosticliver function of NICCD children, they were divided into good-prognosis group (ALB=35-55 g/L, alanine transaminase≤40 U/L)(43 cases) and bad-prognosis group(ALB<35 g/L or ALB>55 g/L, alaninetransaminase>40 U/L)(13 cases). ROC was used to describe the efficiency of the degree of subcostal hepatomegaly and coagulation indexes in predicting the prognostic liver function of NICCD children. Results:The degree of subcostal hepatomegalyand the APTT level were significantly higher in low-ALB group than in normal-ALB group,while FIB level was significantly lower, and there was statistical difference (P<0.05); there was no statistical difference in the PT level or TT level between the two groups(P>0.05). Pearson correlation analysis showedthat the ALB level was negatively correlated with the degree of subcostal hepatomegaly and APTT level, andpositively correlated with FIB level (P<0.05), but not correlated with PT or TT level(P>0.05). The degree of subcostal hepatomegaly and APTT level were significantly lower in good-prognosis group than in bad-prognosis group, while FIB level was significantly higher(P<0.05), but there was no statistical difference in PT or TT level between the two groups(P>0.05). The cut-off value of the degree of subcostal hepatomegaly, APTT and FIB in predicting bad prognosis of NICCD children was 3.3 cm, 46.7 s and 1.4 g/L, respectively. Conclusion:The level of serum ALB is related to the degree of subcostal hepatomegaly and coagulation function inNICCD children, and the degree of subcostal hepatomegaly and the level of APTT and FIB of NICCD children are closely correlated with their prognostic liver function, so the detection of them can be used in the prevention and treatment of bad prognosis of liver function in neonates. Related Articles | Metrics

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Expert consensus in integrated traditional Chinese and western medicine prevention and treatment for influenza in children Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (5): 369-374.   Abstract （355）      PDF（pc） （830KB）（235）       Knowledge map    Save Children are the highrisk population of influenza(flu) and its severe cases. The morbidity is high in the flu season, and in severe cases it may result in death. Currently, the effective western medicines for flu viruses are limited, and the treatment with western medicines alone has its limitations. In the theory of traditional Chinese medicine, flu belongs to seasonal cold, which is highly infectious, and it also belongs to "plague" in traditional Chinese medicine has had valuable experience in the prevention and treatment of "plague", but it also has its limitations. Therefore, the integration of Chinese with western medicine which takes advantage of both traditional Chinese and western medicine, will have its unique advantages, especially in the early intervention of mild cases. Based on the review on the advances in modern prevention and treatment of flu in children, the analysis of literatures on Chinese medicine treatment for child flu, the drug assessment questionnaire and the application experience of the experts, the consensus aims to standardize the combined use of Chinese and western medicines, in order to find solutions to the clinical problem of the prevention and treatment for influenza in children, especially for mild cases. Related Articles | Metrics

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Evaluation of therapeutic effect of Yiqi Huayu Qingre decoction on pediatric hormone-sensitive nephrotic syndrome GAO Xuguang, YANG Meng, ZHANG Maohua, ZHAI Wensheng Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 358-.   Abstract （345）      PDF（pc） （600KB）（14）       Knowledge map    Save Objective: To observe the curative effect of Yiqi Huayu Qingre decoction on hormone-sensitive nephrotic syndrome in children. Methods: A total of 69 outpatients or inpatients with hormone-sensitive nephrotic syndrome treated in the First Affiliated Hospital of Henan University of Chinese Medicine and Zhengzhou Children's Hospital from July 2017 to July 2018 were enrolled in this study. Prospective cohort study was used. The 32 outpatients or inpatients with hormone-sensitive nephrotic syndrome in the First Affiliated Hospital of Henan University of ChineseMedicine were treated with Yiqi Huayu Qingre decoction on the basis of western medicine(observation group), and the 37 children with hormone-sensitive nephrotic syndrome treated with western medicine in outpatient or inpatient department of Zhengzhou Children's Hospital were selected as the control group. The control group was treated with glucocorticoid, and the observation group was treated with Yiqi Huayu Qingredecoction on the basis of glucocorticoid. The efficacy and hormone-related side effects were observed before treatment and 2 weeks,4 weeks,8 weeks,12 weeks and 36 weeks after treatment. Results:After 2 weeks of treatment, there were 15 cases of complete remission and 17 cases of partial remission in observation group. In the control group,6 cases were completely relieved,28 cases were partially relieved, and 3 cases were not relieved. The curative effect of the observation group was better than that of the control group, and the difference was statistically significant(P=0.008).During the 36-week treatment, the recurrence rate of the observation group was 12.5%(4/32),which was significantly lower than that of the control group(35.1%,13/37),and the difference was statistically significant(P=0.048).The incidence of infection in the observationgroup was 31.3%(10/32),which was lower than 59.5%(22/37) in the control group, and the difference was statistically significant(P=0.029).There was no significant difference in buffalo hump or moon facecaused by hormones between the two groups(P>0.05).After 8 weeks of treatment, the sweating score and irritability score of the observation group were significantly lower than those of the control group, and the differencewas statistically significant(P<0.05). Conclusion: Yiqi Huayu Qingre decoction can shorten the remissiontime of nephrotic syndrome, reduce the number of infections, reduce the recurrence rate, and reduce the sweating and irritability caused by hormones. Related Articles | Metrics

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Study on the correlation between early language development and sleep in toddlers aged 12 to 30 months LIU Fang, TANG Zhijuan, TAN Lijun, LEI Yanbo, LIANG Yi, SHI Yun, LUO Zuying, ZHOU Liting, NONG Ruizhen Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 317-.   Abstract （313）      PDF（pc） （542KB）（23）       Knowledge map    Save Objective:To study the correlation between early language development and sleep in children. Methods:A total of 255 toddlers aged 12 to 30 months were chosen, who underwent physical examination in the Child Healthcare Clinicof Liuzhou Traditional Chinese Hospital from April 2019 to June 2020. Besides the physical examination, Early Language Development Progression Scale was used to evaluate the language development of the toddlers, and at the same time, the Brief Infant Sleep Questionnaire(BISQ) was adopted to collect the sleep information, and the results were statistically analyzed. Results:The evaluation of the early language development in these 255 toddlers showedthat the total development quotient was (32.04±19.09); the total development age was (13.09±9.19)months; the total sleep duration was (12.52±2.83)hours: the day sleep duration was (3.08±5.66), and the number of night wakening was (1.54±1.41); the correlation coefficient of the total development months of the Early Language Development Progression Scale and the development months and the development quotient of the subscale A with total 24h sleep duration was 0.6 to 0.8, which showed that there was a strong positive relationship. The correlation coefficient of the total development quotient of the Early Language Development Progression Scale, the development months and development quotient of subscale B and subscale C with total 24h sleep duration was 0.4 to 0.6, which showed that there was a moderate positive relationship.There was a moderate negative relationship between the evaluation results of early language development and the number of night wakening, no relationship with night sleep duration, a weak relationship with day sleep duration, and a weak negative relationship with night wakening duration. Conclusion:There is a strong positive relationship between early language development and sleep duration of the toddlers and a weak positive relationship with day sleep duration. Related Articles | Metrics

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Analysis of the curative effect of modified Sangbaipi decoction on pertussis-like syndrome in children MAIYuechang, LIN Qianwen Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 362-.   Abstract （303）      PDF（pc） （521KB）（35）       Knowledge map    Save Objective: To explore the effect of modified Sangbaipi decoction on children with pertussis-like syndrome. Methods: Forty cases of children withpertussis-like syndrome treated in our hospital from January 2017 to December 2019 were randomly divided into control group(20 cases, treated with azithromycin) and observation group(20 cases, treated with Sangbaipi decoction and azithrpmycin). The total effective rate, inflammatory factor level, pulmonary function index, disappearance time of main symptoms, recovery time of blood routine and hospitalization time were compared between the two groups. Results: The total effective rate of the observation group(95.0%,19/20) was higher than that of the control group(65.0%,13/20)(P<0.05);the respiratory rate of the observation group after treatment was lower than that of the control group, and the tidal volume and inspiration/expiration ratio after treatment were higher than those of the control group(P<0.05); the white blood cell count and C-reactive protein level in the observation group werelower than those in the control group(P<0.05); the disappearance time of main symptoms and the recovery time of blood routine in the observation group were all lower than those in the control group(P<0.05). Compared with thecontrol group, the hospitalization time was shorter(P<0.05). Conclusion: The application of modified Sangbaipi decoction in the treatment of children with pertussis-like syndrome is helpful to enhance the curative effect, improve the lung function, reduce the inflammatory reaction and accelerate the recovery of the disease. Related Articles | Metrics

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Clinical effects of budesonide combined with pulmonary surfactant on bronchopulmonary dysplasia in preterm infants ZHU Xiyi, WEN Zhihong, LI Fubing, XIE Yuyan, WEI Xiuzhen Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 277-.   Abstract （296）      PDF（pc） （486KB）（23）       Knowledge map    Save Objective:To construct Atg7-gene-0knockout human brain microvascular endothelial cells(HBMEC) by CRISPR/cas9 technology, so as to provide an in vitro cell model for the role of Atg7 in the development of cerebral vessels, the mechanism of Atg7 participating in the formation of blood-brain barrier and thestudy of cerebrovascular diseases. Methods:Two pairs of guiding RNA sequences(sgRNA) were designed according to exon 1 of human Atg7. HBMEC was transfected with lentivirus; puromycin and Pyricularia oryzae were used to screen for cells successfully transfected. RT-qPCR and Western blotting were used to detect the mRNA and protein of the target gene, and the morphological changes were observed under the microscope. Results:The CRISPR/cas9 plasmid targeting Atg7 was constructed. The results of RT-qPCR, Western blot and immunofluorescence showed that stable Atg7-knockout human brain microvascular endothelial cell line was obtained by monoclonal screening. No obvious morphological changes were observed under light microscope. Conclusion:The successful construction of human brain microvascular endothelial cells with Atg7 gene knockout by CRISPR/cas9 technology is beneficial to the development of cerebral vessels, the mechanism of blood-brain barrier morphogenesis and the study of cerebrovascular diseases. Related Articles | Metrics

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Clinical study of modified Xiaoqinglong decoction in the treatment of children with bronchial asthma of external-coldness and internal-drink type during acute onset WAN Jun, YU Zhou, TAN Yinghui, YANG Zeyi, YANG Xiangzheng Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 353-.   Abstract （278）      PDF（pc） （643KB）（43）       Knowledge map    Save Objective: To study the clinical effect of modified Xiaoqinglong decoction in the treatment of children with bronchial asthma ofexternal-coldness and internal-drink type. Methods: A total of 80 children with bronchial asthma of external-coldness andinternal-drink type were treated in our hospital between February 2019 and August 2020, and they were divided into observation group and control group, with 40 cases in each group. Both groups were treated with conventional western medicine, and the observation group was also treated given modified Xiaoqinglong decoction, and the use of hormone was reduced by a half. After one week of treatment, the clinical effect wascompared between the two groups, and compare the total traditional Chinese syndrome score, FEV1%, FEV1/FVC, PEF andFeNO before and treatment, the childhood asthma control test and the adverse reactions were evaluated. Results: After treatment, the total effective rates of the observation group and the control groupwere 92.3% and 71.0%, respectively, with statistically significant differences between the twogroups(P<0.05). After one week of treatment, the total score of TCM syndromes in the observation group was significantly lower than that of the control group(P<0.01), lung function was significantly better(P<0.05), FeNO was significantly lower than that of the control group, and the control test of asthmain the observation group was better than that in the control group(P<0.01). No adverse reactions occurred in both groups during the treatment. Conclusion: On the basis of conventional western medicine treatment, the dosage of hormone is halved, and Xiaoqinglong decoction can be used to treat children with  bronchial asthma of external-cold and internal-drink type during acute onset, which is effective and worthy of further clinical promotion. Related Articles | Metrics

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Analysis of clinical characteristics of children with orthostatic intolerance in Inner Mongolia CHANG Xin, CHEN Liqing Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (3): 274-277.   Abstract （271）      PDF（pc） （350KB）（23）       Knowledge map    Save Objective: To explore the clinical characteristics of children with orthostatic intolerance(OI), strengthen the understanding of OI, and improve the level of diagnosis and treatment of OI. Methods: A retrospectiveanalysis of 102 cases of orthostatic intolerance was conducted, who were treated from January 2018 to December 2019 in the Maternal and Child Health Hospital of Inner Mongolia Autonomous Region to explore the clinical characteristics of orthostatic intolerance. Among them, 62 children with orthostatic intolerance confirmed by HUTT were included as the observation group, and 40 children with negative HUTT were included as the control group. Results: In 62 cases of OI, 43 cases (69.4%) were VVS, 17 cases(27.4%) were POTS and 2 cases(3.2%) were OHT. Among the 62 cases, 55 cases(88.7%) had induced factors, including 20 cases(32.2%) of longterm standing, 17 cases(27.4%) of posture change, 14 cases(22.6%) of strenuous exercise. Among the 62 cases,52 cases(83.8%) had precursory symptoms in head-up tilt test(HUTT). The common manifestations were dizziness in 33 cases(53.2%), chest tightness in 24 cases(38.7%), palpitation in 23 cases(37.1%), and color change in 23 cases(37.1%). Arrhythmias were found in all OI children, including 55 cases(88.7%) of sinus tachycardia and 13 cases(21.0%) of sinus bradycardia. Conclusion: The main inducing factors of OI are standing for a long time, body position change, etc., and the main precursory manifestations are dizziness, chest pain, palpitation, etc. Related Articles | Metrics

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Advances in research on the treatment for upper airway cough syndrome based on TCM syndrome differentiation YUAN Jianzai, ZHANG Li, YUAN Yehong, MA Shuxia Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 301-.   Abstract （245）      PDF（pc） （844KB）（33）       Knowledge map    Save Upper airway cough syndrome(UACS) used to be described as "postnasal drip syndrome", which is the main cause of chronic wet cough in children at 1 year old and above. The treatment based on syndrome differentiation for this disease bytraditional Chinese medicine has the characteristics of quick efficacy, few side effects, low recurrence rate andenhanced immunity and has been widely recognized. It is summarized that the cause of the disease is wind,phlegm, deficiency and stasis, and the core pathogenesis is "the deficiency of lung and spleen qi, retention of wind and phlegm, binding of phlegm and stasis, and discomfort in lung, noseand throat". It is suggested that the diagnosis by western medicine should be combined with TCM syndrome differentiation and constitution differentiation, and the treatment should be to disperse wind and relieve the lung and fever, strengthen the spleen and reduce phlegm and stasis, which is the main treatment principle, and the symptomatic treatment, such as clearing fever, nourishing yin, moistening dryness and promoting digestion, can also be used. Meanwhile, pay attention to some TCM exterior therapies, including external application of Chinese medicines, massage for children and indirect moxibustion. Related Articles | Metrics

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Spectrum analysis of acute respiratory virus infection in children in Lanzhou city from 2017 to 2018 SHAO Lili, DONG Xinfang, DING Xia, JIAO Qiongjie, ZHANG Shimei, NI Qian Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (3): 269-274.   Abstract （238）      PDF（pc） （819KB）（9）       Knowledge map    Save Objective: To understand the viral pathogen composition and epidemic characteristics of children aged 0-14 year old with acute respiratory tract infection(ARTI) in Lanzhou city from 2017 to 2018, and to provide clinical basis for the diagnosis and prevention of ARTI in children. Methods: A total of 188 pharyngeal swabs of children with ARTI were collected from outpatient department, whichmeet the inclusion criteria, in Lanzhou University Second Hospital from October 2017 to September 2018. Capillary electrophoresiswas used to detect Influenza virus(IFV)A and B(IFVA, IFVB), respiratory syncytial virus(RSV)A and B(RSVA, RSVB), parainfluenza virus (PIV)1.4(PIV1.4), adenovirus(ADV), human metapneumonia virus(HMPV), human bocavirus(HBoV), rhinovirus/human enterovirus(HRV/HEV), and human coronavirus(HCoV).  Results: At least one kind of viruses was detected in 173 out of 188 cases, the overall positive rate was 92.02%. The positive rate of RVS was highest with a value of 34.0% (64/188), followed by IFV 30.9% (58/188), PIV 22.9% (43/188), ADV 19.1%（36/188）, HRV/HEV 10.6%（20/188）, HCoV 7.4%（14/188）, HBoV 3.2%（6/188）and HMPV 2.1%（4/188）. There were 44 cases(23.4%) of mixed infectionof two or more kinds of viruses. There was no significant seasonal difference in the positive rate of RSV, IFV and ADV, and the positive rate of PIV, HRV/HEV and HCoV was significantly increased. The positive rate of respiratory virus in children under 1 year old was the highest, reaching 100.0%.  Conclusion: Child ARTI in Lanzhou city from October 2017 to September 2018 are mainly caused by RSV, IFV, PIV and ADV, and should be controlled through the whole year. Virus infection is the main pathogen at early stages of child ARTI under 1 year old, and the routine use of antimicrobial agents is not appropriate. Related Articles | Metrics

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Analysis of medication rules in children with pharyngitis based on data mining YUE Sicong, ZHANG Weidong, TANG Shubin Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (3): 213-218.   Abstract （232）      PDF（pc） （829KB）（7）       Knowledge map    Save Objective: To explore the medication data in children with pharyngitis treated by Prof. Zhang Weidong, the chief physician, and to study the characteristics of his medication and the rules of prescription. Methods: The clinical prescriptions of Prof. Zhang in the treatment of children with pharyngitis were collected. Excel and IBM SPSS 22.0 softwares were used to establish the database. A total of 700 prescriptions were analyzed by IBM SPSS Modeler 18 and Apriori algorithm of association rules, concerning the types and channel tropism of medicines, frequency in use, and the medication rules. The charts were used to describe them. Results: The top five drugs, based on the frequency in use, were Baikal Skullcap, radix scrophulariae,scorched hawthorn fruit, licorice and Forsythia suspensa. The top three types of drugs with high frequency were heat-clearing drugs, the drugs for relieving cough and reducing sputum and the drugs for tonifying deficiency. The drugs were mainly cold, warm and mild in nature, and they were mostly sweet, bitter and pungent. The top three types of channel tropism of high-frequency drugs were in turn liver meridian, lung meridian and stomach meridian. According to association rules analysis, it was concluded that radix scrophulariae, Fritillariathunbergii, scorched hawthorn fruit, Baikal Skullcap, Forsythia suspensa, Licorice and dark plum were the core drugs. Conclusion: Based on the analysis of the frequency in drug use, association and organs, it is shown that Prof. Zhang focuses on nourishing Yin, clearing heat, detoxification and resolving phlegm and blood stasis in the medication. Related Articles | Metrics

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Diagnosis and treatment status of related diseases after group A hemolytic streptococcus infection YANG Yanxia, WANG Hong Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 306-.   Abstract （210）      PDF（pc） （605KB）（12）       Knowledge map    Save Group A hemolytic streptococcus(GAS) is gram-positive cocci, which can cause diseases all over the world. The incidence rate in children is higher than that in adults. After infection, it can cause a variety of diseases. The infection ranges from superficial infections (pharyngitis and local skin infections), to invasive infection (toxic shock due to GAS infection), and it can also cause autoimmune diseases. At present, the treatment for streptococcal infection has not been standardized. Penicillin is the first choice for the symptoms and signs of acute infection. Azithromycin, erythromycin, and vancomycin are theother choice drugs for patients with penicillin allergy. Systemic anti-infection treatment can reduce long-term complications.  Related Articles | Metrics

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Analysis of the effect of psychomotor therapy combined with behavioral therapy on children with attention-deficit-hyperactivity-disorder aged 4 to 6 XU Xichang, SUN Yinghong, ZHOU Fan, YANG Jie, JIN Shengli Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (5): 388-391.   Abstract （206）      PDF（pc） （488KB）（38）       Knowledge map    Save Objective:To explore the therapeutic effect of psychomotor therapy combined with behavioral therapy on children with attention-deficit hyperactivity disorder(ADHD) aged 4 to 6. Methods:Forty children aged 4 to 6 with ADHD were divided into an observation group(20 cases) and a control group(20 cases) according to a random number table. They were diagnosed and received therapy in Affiliated Hospital of Jiangsu University from January to December 2019. The observation group received 24 weeks of psychomotor therapy combined with behavioral therapy and the control group only received 24 weeks of behavioral therapy. The Conners Parent Symptom Questionnaire(PSQ) was used to evaluate the observation group and the control group before treatment, during treatment (12th week) and after treatment. Results:Compared with before treatment, the observation group has different PSQ during and after treatment. The scores of each factor were significantly reduced, with statistical differences(P<0.01). There were statistical differences in the behavior problems(P<0.01) and psychosomatic disorders(P<0.05) of the control group during the treatment, but there were no differences in other factors. The PSQ factor scores of the control group were significantly reduced after treatment, with statistical differences(P<0.01). During and aftertreatment, the scores of PSQ factors of the observation group were all lower than those of the control group, the differences being statistically significant (P<0.01). Conclusion:Psychomotor therapy combined with behavioral therapy can effectively solve some problems in children with ADHD. It is effective at 12 weeks of treatment, and the effect is significant after long-term treatment. Related Articles | Metrics

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Different doses of dexmedetomidineby nasal dripping in surgery for pediatric hernia LI Peng Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (4): 328-.   Abstract （205）      PDF（pc） （436KB）（16）       Knowledge map    Save Objective:To investigate the efficacy and safety of dexmedetomidine (DEX) by nasal dripping in surgery for pediatric hernia. Methods:A total of 90 children undergoing elective hernia surgery were divided into 3 groups with 30 cases in eachgroup by random number table method. They were divided into saline solution control group (control group), DEX 1.0 μg/kg group (low dose group), DEX 2.0 μg/kg group (high dose group).The time of anesthesia, operation, wake-up and extubation and total dosage of remifentanil and propofol during anesthesia were recorded, respectively. HR and SpO-2 were recorded before and at 10 min, 20 min and 30 min after intranasal DEX administration. After the operation, the agitation was evaluated by agitation scoring method on wake-up and at 15 min, 30 min and 60 min after wake-up. Results:There was no statistically significant difference in the time of anesthesia, operation, wake-up and extubation among the 3 groups(P>0.05). The dosage of remifentanil and propofol in control group was significantly higher than that in the other two groups, and the dosage in the high dose group was significantly lower than that in the low dose group, the difference being statistically significant. There was no significant difference in the HR at any time points(P>0.05). Compared with SpO-2before intranasal DEX administration, SpO-2 in low dose group was decreased at 30 min(P<0.05), and SpO-2 was decreased at every time points after intranasal administration in high dose group(P<0.05). SpO-2 in high dose group was significantly lower than that of control group at every time points(P<0.05). The agitation scores after at each time point after wake-up in the high dose group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05). Conclusion:Nasal dripping pretreatmentwith 2.0 μg/kg DEX can significantly reduce the dosage of other intravenous anesthetics and the occurrence of agitation during hernia operation without prolonging the time of wake-up, which is worthy of clinical promotion and popularization. Related Articles | Metrics