ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (3): 218-221.doi: 10.3969/j.issn.1674-3865.2019.03.010

• 综述 • 上一篇    下一篇

阻塞性睡眠呼吸暂停低通气综合征在妊娠期高血压及胎儿低氧血症发病机制中的研究进展

徐畅，丛芳   

  1. 116044 大连，大连医科大学附属第二学院2015级临床医学专业本科生（徐畅）；110002 沈阳，大连医科大学附属沈阳市口腔医院科研科（丛芳）
  • 收稿日期:2019-02-25 出版日期:2019-06-25 上线日期:2019-06-25
  • 通讯作者: 丛芳，E-mail：grasscf@sina.com
  • 作者简介:徐畅(1997-)，女，大连医科大学附属第二学院2015级本科生在读。研究方向：新生儿低氧血症的研究

Research progress of OSA in the pathogenesis of HDP and maternal hypoxemia

XU Chang，CONG Fang   

  1. Second College Affiliated to Dalian Medical University，Dalian 116044，China
  • Received:2019-02-25 Published:2019-06-25 Online:2019-06-25
  • Contact: CONG Fang，E-mail：grasscf@sina.com

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摘要： 肥胖在中国孕妇中日益普遍，15%～20%的肥胖孕妇患阻塞性睡眠呼吸暂停（OSA）。未经治疗的OSA将导致一系列心血管、肺和代谢性合并症。妊娠期高血压（HDP）是孕产妇和新生儿发病率和死亡率的主要原因。孕期的OSA可能面临先兆子痫或子痫的风险，导致胎儿的不良结局。OSA与HDP及两者所致的胎儿低氧血症和新生儿相关并发症的关系尚未明确阐明。本文将OSA与HDP之间的关系及其可能的机制，以及减轻这些不良后果方面的有效性加以综述。

关键词: 阻塞性睡眠呼吸暂停, 妊娠期高血压, 胎儿低氧血症, 发病机制

Abstract: Obesity is increasingly common among pregnant women in China; 15%-20% of obese pregnant women have obstructive sleep apnea(OSA). Untreated OSA will result in a range of cardiovascular, pulmonary and metabolic complications. Hypertensive disorder complicating pregnancy (HDP) is the leading cause of maternal and neonatal morbidity and mortality. OSA during pregnancy may be at risk of pre-eclampsia or eclampsia, leading to a poor outcome in the fetus. The relationship between OSA and HDP and its fetal hypoxemia and neonatal related complications has not been clearly elucidated. In this review, we review the relationship between obstructive sleep apnea and hypertensive disorders of pregnancy, its possible mechanisms, and the effectiveness of alleviating these adverse consequences.

Key words: Obstructive sleep apnea, Gestational hypertension, Maternal hypoxemia, Pathogenesis