Abstract: Objective:To investigate the effects of electroacupuncture on the expression of brain-derived neuotrophic factor(BDNF) in the brain tissues of the young offspring of rats with congenital brain damage.Methods:Prepare the brain damage models by injecting LPS 450 μg/(kg·d）into abdominal cavity of pregnant rats on d17 and d18;injecting equally sterile NS into abdominal cavity of contrasting pregnant rats.The LPS young offspring of rats were randomly divided into the non-intervention group and the electroacupuncture group.The electroacupuncture group began intervention from d7 until d28,once a day.Select Baihui,Quchi and Zusanli as intervention points.The control group and the non-intervention group were given regular feeding.Immunohistochemistry was used to detect the expression of BDNF in d1,d14,d21 and d28.Results:The expression of BDNF of the non-intervention group was higher than the control group（P<0.01）in d1,and there was significant difference between the two groups.Compared with the non-intervention group and the control group,the expression of BDNF of the electroacupuncture group was higher（P<0.05）in each period and the difference was significant (P<0.01).Conclusions:Intrauterine infection can cause the increase of the expression of BDNF in neonatal rats with brain damage.Electroacupuncture can persistently increase the expression of BDNF in neonatal rats with brain damage.

Key words: Intrauterine infection, Brain damage, Electroacupuncture, BDNF