Abstract: Objective To observe the clinical effect of repeated transcranial magnetic stimulation combined with comprehensive rehabilitation training on children with global development delay．
Methods A total of 82 children with global development delay were included in the study, who were diagnosed in our hospital and received rehabilitation treatment from Oct. 2018 to Dec. 2019.They were divided into two groups according to whether the children cooperated and whether their families agreed to receive repeated transcranial magnetic stimulation: the observation group(n=45) and the control group(n=37). The two groups of children were evaluated by Gesell development scale and on S-S language development retardation before and after 3 months of treatment, and they also received comprehensive rehabilitation training. The observation group was treated with repeated transcranial magnetic stimulation in addition to comprehensive rehabilitation treatment. The changes in Gesell development scale and S-S language development scores were compared differences in clinical effect were compared between the two groups and among children with different degree of disease and at different age in the observation group.
Results Gesell development scale scores on adaptability, fine motion ability, language and social ability and S-S language development scores of the two groups were significantly higher after treatment than before treatment, and the scores of the observation group were higher than those of the control group（P<0.05). The total effective rate of the observation group was significantly higher than that of the control group, and there was statistical difference（P<0.05).In the observation group, the total clinical effective rate of the mild cases and the 3 to 4 years old children was significantly higher than the moderate and severe cases and the 4.1 to 5 years old children in Gesell development scale evaluation and S-S language developmental delay evaluation, and there was statistical difference（P<0.05).
Conclusion Repeated transcranial magnetic stimulation can improve the cognition and language ability of children with global developmental delay, and in the children at young age and with mild condition, the effect is especially significant.

Key words: Global developmental delayRepeated transcranial magnetic stimulation, Rehabilitation intervention, Child