Table of Content

25 August 2020, Volume 12 Issue 4 Previous Issue    Next Issue

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General knowledge on TCM understanding and treatment of children with multiple tic syndrome 2020, 12 (4):  277-280.  doi: 10.3969/j.issn.1674-3865.2020.04.001 Abstract ( 395 )   PDF (499KB) ( 106 )   Save The understanding of traditional Chinese medicine for multiple tic syndrome is as follows: in terms of syndrome differentiation and treatment, most medical doctors mainly focus on organ differentiation and illness; in terms of pathogenesis, most medical doctors believe that the pathogenesis of this disease is the deficiency in origin and excess in superficiality, specifically manifested as deficiency in liver, spleen and kidney, and wind, fire and phlegm are interlinked; in terms of disease location, the main disease location of multiple tics is in the liver, and is closely related to the heart, lung, spleen, kidney and other organs. Based on the above knowledge, experimental researches and clinical researches on multiple tics are carried out in TCM, which shows that TCM treatment for multiple tics can control the symptoms of tics and improve the quality of life of children. Therefore, Chinese medicine is one of the effective methods in treating children with multiple tics. Related Articles | Metrics

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Analysis of Professor Xiong Lei 's experience in treating children with Tic disorder by the method of Expelling excess with mild diaphoretic 2020, 12 (4):  281-284.  doi: 10.3969/j.issn.1674-3865.2020.04.002 Abstract ( 246 )   PDF (572KB) ( 140 )   Save Tic disorder is a chronic neuropsychiatric disorder with the onset at childhood, which is mainly manifested as involuntary, repeated, rapid and sudden attack as well as arrhythmic sports tics or vocal tics of one or multiple muscle groups. The pathogenesis of this disease is not yet clear, and in recent years its incidence has been obviously increasing. The condition of the disease is likely to vary or relapse and with a relatively long course, which affects the life quality and physical and mental health of the children. Professor Xiong Lei has rich experience in managing the disease, and she is especially good at using the method of Expelling excess with mild diaphoretic is analyzed based on the theories, clinical experience and prescriptions, aiming to provide diverse thoughts on the treatment of the disease. Related Articles | Metrics

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Clinical observation on Anshen Ningzhi massage combined with traditional Chinese medicine for children's tic disorder 2020, 12 (4):  284-287.  doi: 10.3969/j.issn.1674〖-3865.2020.04.003 Abstract ( 151 )   PDF (507KB) ( 91 )   Save Objective To observe the clinical effect of Anshen Ningzhi massage combined with traditional Chinese medicine orally taken in the treatment of children with tic disorder(hepatic hyperactivity and windinduced phlegm syndrome). Methods Seventy children with tic disorder (hepatic hyperactivity and wind-induced phlegm syndrome),who were treated in our pediatric clinic from Aug. 2018 to Aug. 2019, were randomly divided into treatment group and control group, with 35 cases in each group. The treatment group received Anshen Ningzhi massage combined with Chinese medicine decoction, while the control group was treated with Chinese medicine decoction alone. After 4 weeks of treatment, YGTSS scale scores and TCM syndrome quantified scores were evaluated. Results After 4 weeks of treatment, the motion score and the total score of the observation group were lower than those of the control group, the difference being statistical(P>0.05). The TCM syndrome quantified score of the observation group was lower than that of the control group after treatment(P<0.05).There was no statistical difference in the total effective rate between the two groups after 4 weeks of treatment(P>0.05).The cured and effective rate was 65.7%(23/35) in the observation group, significantly higher than that of the control group(40.0%,14/35), and there was statistical difference(P<0.05). Conclusion Anshen Ningzhi massage combined with oral Chinese medicine can significantly improve the tic symptoms in children with tic disorder (hepatic hyperactivity and wind-induced phlegm syndrome), and the clinical effect is positive. Related Articles | Metrics

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Professor Juwei's experience in the prevention and treatment of ADHD in children based on the children's constitution 2020, 12 (4):  288-290.  doi: 10.3969/j.issn.1674-3865.2020.04.004 Abstract ( 218 )   PDF (416KB) ( 78 )   Save This article mainly introduces Professor Juwei's experience in the prevention and treatment of ADHD in children based on the children's constitution. Professor Ju Wei advocates that syndrome differentiation should be made first, and then constitution differentiation. During the treatment, traditional Chinese medicine should be combined with western medicine. The diagnosis clarified based on the thoughts of western medicine, and the disease is managed based on TCM thoughts. Thus, the advantages of TCM and western medicine are fully utilized and the effect is very good. Related Articles | Metrics

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Research progress in postinfection-bronchiolitis obliterans in children 2020, 12 (4):  291-294.  doi: 10.3969/j.issn.1674-3865.2020.04.005 Abstract ( 290 )   PDF (441KB) ( 86 )   Save Postinfection-bronchiolitis obliterans in children is the most common bronchiolitis obliterans in children. The pathological features are small airway stenosis and occlusion in lung, and pulmonary fibrosis. Clinical manifestations mainly include persistent cough and asthma, polypnea and dyspnea，with poor prognosis. The diagnosis also depends on the related auxiliary examinations. In the treatment, glucocorticoid drugs can be used as the targeted therapy drugs, and the macrolides, leukotriene receptor antagonist and oxygen therapy are also useful. Because of the poor prognosis, transplantation is feasible in very few children. Related Articles | Metrics

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Application of the combination of Periostracum cicadae and Bombyx batryticatus in the treatment of childhood common diseases 2020, 12 (4):  295-297.  doi: 10.3969/j.issn.1674-3865.2020.04.006 Abstract ( 279 )   PDF (441KB) ( 109 )   Save Periostracum cicadae and Bombyx batryticatus can affect lung and liver meridian, and have the effect of dispelling wind pathogens, relieving spasm, clearing heat and relieving sore throat, eliminating urticaria to relieve itching, and so on. Modern pharmacological studies have shown that they have bacteriostatic, anti-inflammatory, antipyretic, analgesic, antiasthmatic, and antiallergic effects. According to the effects, they are often used in combination clinically to treat exopathogenic fever, pertussis-like syndrome, urticaria, and Tourette syndrome in children, and get pretty good clinical therapeutic effect. Related Articles | Metrics

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Study on the mechanism of Uncaria rhynchophylla in the treatment of febrile convulsion based on network pharmacology 2020, 12 (4):  298-303.  doi: 10.3969/j.issn.1674-3865.2020.04.007 Abstract ( 363 )   PDF (671KB) ( 72 )   Save Objective To explore the molecular mechanism of Uncaria rhynchophylla in the treatment of febrile convulsion by using network pharmacology. Methods The main active components of Uncaria rhynchophylla were obtained through TCMSP database and literature mining, and the targets of active components of Uncaria rhynchophylla were predicted and screened by Perl language analysis, OMIM and Gene Cards database. Cytoscape software was used to construct component-target-pathway-disease network. A protein interaction network was mapped using the String database. With the help of Bioconductor-cluster Profiler database, GO analysis and KEGG pathway analysis were carried out on targets. Results Totally 27 active components of Uncaria rhynchophylla were screened, mainly alkaloids, terpenes and flavonoinds, and alkaloids accounted for the most part, and 46 targets were involved. Uncaria rhynchophylla could play a role in treating FC by regulating AGE-RAGE, IL-17, HIF-1,TNF,PI3K-Akt and other signaling pathways. Conclusion The active components, such as alkaloids, terpenes and flavonoids, in Uncaria rhynchophylla may be the material basis for treating FC, and their mechanism of action involves signal pathways such as AGE-RAGE,IL-17,HIF-1,TNF,PI3K-Akt.Uncaria rhynchophylla is effective in treating FC by regulating inflammatory response, cell apoptosis and the adaptability of neurons to hypoxia. Related Articles | Metrics

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A study on the seasonal trend of asthmatic diseases in children based on time series 2020, 12 (4):  304-308.  doi: 10.3969/j.issn.1674-3865.2020.04.008 Abstract ( 192 )   PDF (815KB) ( 46 )   Save Objective To analyze and study the seasonal regularity of wheezing children in pediatric emergency. Methods Count and record the visits of children with wheezing diseases in Guangdong Provincial Hospital of Traditional Chinese Medicine from January 2014 to December 2019. Based on the time series prediction module of SPSS Statistics 24 software, the data were analyzed; the original series were seasonally decomposed, stabilized; the best model was established and selected; the fitting effect and prediction effect of the model were evaluated. Among them, the data from January 2013 to June 2019 were used for modeling, and the data from July to December 2019 were used as an internal verification set to evaluate the prediction effect of the model. Results Both the original series and the seasonal factor series showed obvious seasonal trend, and the exponential smoothing model was selected by smoothing the original series. The model had good fitting ability, and the predicted values were within 95% confidence interval. Conclusion The incidence of wheezing diseases in children has an obvious seasonal trend. Related Articles | Metrics

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Effect of early swallowing training on dysphagia in children with severe viral encephalitis 2020, 12 (4):  308-311.  doi: 10.3969/j.issn.1674-3865.2020.04.009 Abstract ( 372 )   PDF (463KB) ( 63 )   Save Objective To investigate the effect of early bedside swallowing training on the recovery of swallowing function in children with severe viral encephalitis. Methods A total of 72 children with severe viral encephalitis admitted to our hospital from January 2018 to October 2019 were enrolled. They were divided into observation group (early bedside swallowing training group) and control group (conventional treatment group)，each with 36 cases, according to the random number table method. Both groups were given conventional Chinese and Western medicine treatment for viral encephalitis. For the observation group，the rehabilitation therapist provided bedside swallowing function training. After a treatment of one month，3 months and 6 months，the recovery of swallowing function and the incidence of complications were observed and compared between the two groups. Results The total effective rate of the observation group after the early bedside swallowing training was better than that of the control group after 3 months and 6 months of treatment(P<0.05). The incidence of complications was lower in the observation group than that in the control group after 6 months of treatment(P<0.05). Conclusion Early bedside swallowing training can not only promote the recovery of swallowing function in children with severe viral encephalitis complicated with dysphagia，but also effectively reduce the occurrence of complications and ensure the implementation of other rehabilitation treatments，which is worthy of clinical promotion. Related Articles | Metrics

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Study on the rule of drug administration in traditional Chinese medicine treatment for children with bronchiolitis obliterans 2020, 12 (4):  312-316.  doi: 10.3969/j.issn.1674-3865.2020.04.010 Abstract ( 348 )   PDF (729KB) ( 53 )   Save Objective To study the rules of drug administration and prescription in traditional Chinese medicine(TCM) treatment for children with bronchiolitis obliterans based on TCM inheritance system software. Methods The prescriptions for bronchiolitis obliterans in children were collected and sorted out in respiratory ward of Pediatric Department of the First Hospital Affiliated to Henan University of Traditional Chinese Medicine. The unsupervised data-mining methods, such as the Apriori algorithm and the complex system entropy clustering, were adopted to find out frequency of drug use and the association rules among drugs, and to analyze the characteristics of drug use and the prescription rules in TCM treatment for children with bronchiolitis obliterans. Results A total of 122 prescriptions were included, involving 109 Chinese medicines. Twenty kinds of medicines were used more than 50 times; when the support degree was 72 and the confidence degree was 0.96, there were 22 drug combinations. In addition, 28 core compatible combinations and 14 new prescriptions were discovered, which could be used in the treatment of the disease. Conclusion The pathogenesis of bronchiolitis obliterans in children is associated with stagnation of sputum, blood stasis, deficiency and blockade. The treatment should be performed according to phases. During the acute phase, the drugs with the effect of clearing lungs and reducing phlegm, relieving cough and asthma and dispelling stasis and dredging collaterals, should be used; besides, attention should be paid to the use of drugs for warming Yang and strengthening body. Related Articles | Metrics

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Effects of traditional Chinese medicine fumigation combined with rehabilitation training on motor function and muscle tension of children with spastic cerebral palsy 2020, 12 (4):  316-319.  doi: 10.3969/j.issn.1674-3865.2020.04.011 Abstract ( 274 )   PDF (523KB) ( 82 )   Save Objective To investigate the effects of traditional Chinese medicine fumigation combined with rehabilitation training on motor function and muscle tension of children with spastic cerebral palsy. Methods Totally 86 cases of children with spastic cerebral palsy admitted to our hospital from July 2018 to December 2019 were selected and divided into two groups according to the random number table method, with 43 cases in each group. The control group was given comprehensive rehabilitation training for intervention, and the children in the observation group received traditional Chinese medicine fumigation in addition to the intervention for the control group. The motor function and muscle tension of the two groups were compared, and the incidence of adverse reactions were recorded. Results There was no significant difference in GMFM-88,PDMS-FM or Ashworth between the two groups before the intervention(P>0.05). After treatment, GMFM-88 and PDMS-FM scores in the observation group were (88.49±7.60) and (59.26±9.85), respectively, higher than those in the control group ［(75.78±6.92) and (50.67±8.14)］; after treatment, Ashworth score in the observation group was (1.46±0.81), lower than that in the control group (1.87±0.70); both of the differences were statistically significant(P<0.05). In the observation group, three children had mild adverse reactions, which did not affect the treatment. Conclusion Traditional Chinese medicine fumigation combined with rehabilitation training can effectively improve the motor function of children with spastic cerebral palsy and significantly reduce the muscle tension. The recovery effect is good, and the safety is high. It is worthy of clinical popularization and application. Related Articles | Metrics

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Effect of suspension exercise on rehabilitation results of children with spastic cerebral palsy 2020, 12 (4):  320-323.  doi: 10.3969/j.issn.1674-3865.2020.04.012 Abstract ( 217 )   PDF (415KB) ( 51 )   Save Objective To investigate the effect of suspension exercise on rehabilitation results of children with spastic cerebral palsy(CP). Methods A total of 76 children with spastic cerebral palsy admitted to our hospital from September 2018 to August 2019 were selected as study subjects, and were randomly divided into control group and observation group, with 38 cases in each group. The control group received conventional rehabilitation training, and the observation group was given suspension exercise in addition to the conventional rehabilitation training. After a continuous intervention of 3 months, the gross motor function measure scale-88 (GMFM-88) was used to evaluate the motor function of children in D and E regions; the modified Ashworth scale (MAS) was used to evaluate the muscular tension of the lower extremity; trunk impairment scale (TIS) was used to evaluate the following three dimensions: dynamic balance, static balance and coordination.  After intervention, GMFM88 scores in D and E regions of the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The MAS scores of lower extremity of the observation group at different time points after intervention were lower than those of the control group, and the differences were statistically significant (P<0.05). After intervention, TIS scores in the above three dimensions were higher than those of the control group, and there was statistical difference (P<0.05). Conclusion Suspension exercise can improve gross motor function of the children with spastic cerebral palsy, reduce muscular tension and increase the ability of balance. Related Articles | Metrics

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Analysis of genetic and clinical characteristics of 4 cases of PCDH19 gene-related epilepsy misdiagnosed 2020, 12 (4):  323-327.  doi: 10.3969/j.issn.1674-3865.2020.04.013 Abstract ( 285 )   PDF (2495KB) ( 58 )   Save Objective To improve the ability of clinicians in early disease identification and reduce misdiagnosis and missed diagnosis by analyzing the genetic characteristics and clinical phenotype of 4 cases of PCDH19 gene-related epilepsy misdiagnosed. Methods The clinical data of 4 children with epilepsy related to PCDH19 gene misdiagnosed from 2017 to 2018 were retrospectively analyzed, and the genetic characteristics of the patients were analyzed by Next generation sequencing. The clinical characteristics of the disease and the causes of misdiagnosis were summarized based on the cases in the literature. Results All the 4 children were female, with recurrent fever and convulsion as clinical symptoms, which showed a general rigidity attack, and all of them were characterized by cluster seizures and heat sensitivity. Two patients had different degrees of language developmental disorders. Genetic testing showed that all the 4 children had heterozygous mutation of PCDH19 gene, which were de novo and pathogenic. Conclusion PCDH19 gene-related epilepsy is rare and the symptoms are similar to those of Dravet syndrome, which is likely to be misdiagnosed or missed, but the prognosis is relatively good. The clinical understanding of PCDH19 gene-related epilepsy should be improved, which will be helpful for the early diagnosis and proper treatment of children with epilepsy, as well as provide follow-up guidance for family genetic counseling and prenatal diagnosis. Related Articles | Metrics

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Clinical significance of the determination of N-terminal pro brain natriuretic peptide in children with fulminant myocarditis 2020, 12 (4):  328-330.  doi: 10.3969/j.issn.1674-3865.2020.04.014 Abstract ( 290 )   PDF (313KB) ( 21 )   Save Objective To investigate clinical value of N-terminal pro brain natriuretic peptide(NT-proBNP) detection in children with fulminant myocarditis(FM), in order to guide the diagnosis and treatment of children with FM. Methods A total of 14 children with FM and 14 children with mild myocarditis treated in our hospital from 2008 to 2018 were selected. Fourteen healthy children were selected as healthy control group. The level of NT-proBNP was tested by automatic biochemical analyzer. Results The level of NT-proBNP in FM children at acute stage was significantly higher than that in FM children at recovery stage, the children with mild mycarditis and healthy control group（P＜0.05）. The level of NT-proBNP in mild myocarditis was significantly higher than that in healthy control group（P＜0.05）. Conclusion The level of NT-proBNP may be used as an important marker in the diagnosis and the judgement of prognosis of fulminant myocarditis. Related Articles | Metrics

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Effect of hormone therapy on bone health of patients with Duchenne's muscular dystrophy 2020, 12 (4):  330-334.  doi: 10.3969/j.issn.1674-3865.2020.04.015 Abstract ( 309 )   PDF (550KB) ( 71 )   Save Objective To explore the effect of glucocorticoid on the growth and development of children with Duchenne's muscular dystrophy(DMD) and bone metabolism. Methods This study retrospectively analyzed DMD children with complete dual-energy X-ray absorptiometry (DEXA) bone density reports who were admitted to the neuromyopathy clinic of Children's Hospital of Fudan University from January 2018 to December 2019. Anthropometric measurements, bone mineral density and serum levels of 25 hydroxyvitamin D were collected, and the above data were analyzed. Results All the 99 patients enrolled were boys, with an average age of (7.2±2.1) years. Fifty-two children(52.5%) received glucocorticoids therapy, with an average duration of hormone therapy of 12.0(IQR 3.9,16.7) months. The age of the patients without glucocorticoids therapy were younger than the patients who received glucocorticoids therapy，［(6.3±2.0) years vs. 8.0±1.9 years, P<0.05］. The Z value of the age for height of the patients without glucocorticoids therapy was (-1.6±1.1), and the Z value of the patients with glucocorticoids therapy was (-2.1±1.5), P=0.095. The Z score of BMI of the patients without glucocorticoids therapy was (0.17±1.50), and in the patients with glucocorticoids therapy it was (0.19±1.40), P=0.35. There was no significant difference in Z score of bone mineral density(BMD) between the patients treated with hormone and those without hormone therapy, P=0.294. The serum 25-hydroxyvitamin D value of patients treated with hormone was higher than that of children who were not treated with hormone ［(19.8±8.5)μg/L vs. (17.7±1.3)μg/L, P=0.45］. Conclusion The monitoring and followup of relevant bone metabolism indicators should be routinely improved in children with DMD. Glucocorticoids therapy within 2 years will not significantly affect bone mineral density if relevant nutrient supplements are given to patients. Related Articles | Metrics

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Analysis of modified Wuling powder in the treatment of infantile enuresis 2020, 12 (4):  335-337.  doi: 10.3969/j.issn.1674-3865.2020.04.016 Abstract ( 498 )   PDF (382KB) ( 91 )   Save Enuresis in children is a common disease in pediatrics, and Wuling powder is the common prescription from Zhang Zhongjing to treat water-drink syndrome. At present, there are many reports on Wuling powder to treat this disease. In clinical practice, syndrome differentiation is the main focus, and the powder is modified based on tongue condition, which results in significant effect. The cases in this paper are school-age children with persistent illness, which affects the physical and mental health of children. This article mainly describes the Wuling powder as the main prescription, with additional relief of liver and clearing of mind, to treat recurrent enuresis in children, and the efficacy is accurate. Related Articles | Metrics

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Bronchodilation test in asthmatic children under 5 years old 2020, 12 (4):  337-340.  doi: 10.3969/j.issn.1674-3865.2020.04.017 Abstract ( 193 )   PDF (414KB) ( 23 )   Save Objective To study clinical application of bronchodilation test of tidal breathing lung function test in asthmatic children under 5 years old. Methods A total of 190 asthmatic children who came to our hospital for diagnosis and treatment between Jan. 1,2018 and Oct. 31,2019 were recruited as research subjects. They were divided into three groups according to their ages: group Ⅰ( 6 months to 1 year old,26 cases) , group Ⅱ(1 to 3 years old,72 cases), group Ⅲ(3 to 5 years old,92 cases). According to the degree of bronchial obstruction, the patients were divided into light, medium and severe groups. All received 0.5% salbutamol. Tidal breathing flowvolume loop and parameters obtained before and after aerosol inhalation were evaluated.〖JP〗 Results (1)There was significant difference in TPTEF/TE and VPEF/VE in 190 asthmatic children and the children in groups Ⅱ before and after inhaling the drug(P<0.05).(2)There was significant difference in TPTEF/TE and VPEF/VE in medium and severe groups before and after inhaling the drug(P<0.05).(3)There was significant difference in the positive rate of bronchodilation test among the three groups with different degrees of obstruction(P<0.05). Conclusion Bronchodilation test of tidal breathing lung function test can reflect the reversibility of airway obstruction in asthmatic children under 5 years old. Bronchodilation test of tidal breathing lung function test is of great value in the diagnosis of asthmatic children with severe obstruction. Related Articles | Metrics

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Study on the dynamic change in hemodynamics indexes in 575 neonates of different days and different body weight 2020, 12 (4):  341-344.  doi: 10.3969/j.issn.1674-3865.2020.04.018 Abstract ( 216 )   PDF (306KB) ( 53 )   Save Objective To monitor the dynamic changes in the following indexes with ultrasonic cardiac output monitor(USCOM) in the neonates without circulatory disorder, including cardiac output, stroke volume index(SVI), systemic vascular resistance index(SVRI), cardiac index(CI),ejection fraction(EF) and stroke volume variation(SVV), and to study the reliability of USCOM for dynamic monitoring Methods A total of 575 neonates without circulatory disorder treated in our Neonatal Department from November 2013 to April 2015 were included, and the dynamic changes in CO,SVI,CI,SVRI,EF and SVV of these neonates were determined on 1,3,7 and 14 days after birth. Meanwhile these neonates were divided into two groups: group 1 with body weight over 2 500 g and group 2 no more than 2 500 g; they were also divided into 4 groups based on their days of age, which were group 11,group 13,group 17 and group 114,and group 21,group 23,group 27 and group 214.The results of the determination in aortic region and pulmonary artery region were compared among the neonates of the groups. Results In the neonates of group 1, there was statistical difference in ASVI and ASVRI between 1-day neonates and 3-day neonates(P<0.05), while there was no statistical difference in the other indexes(P>0.05); only ACI had statistical difference between 3-day and 7-day neonates(P=0.03), and no statistical difference existed in the other indexes; there was no statistical difference in FEF, ASVV or FSW between 7-day and 14-day neonates(P>0.05), while the other indexes had statistical difference(P<0.05).In group 2,there was statistical difference in AEF,ACI,FSVI,FCO,FCI and FSVRI between 1-day and 3-day neonates(P<0.05),while there was no statistical difference in the other indexes(P>0.05); there was statistical difference in ACI,FCO and FCI between 3-day and 7-day neonates(P<0.05), while the difference in the other indexes was not statistically significant(P>0.05);between 7-day and 14-day neonates, there was no statistical difference in any index(P>0.05). Conclusion For the neonates without circulatory disorder with body weight over 2 500 g at 3 to 7 days after birth and those no more than 2 500 g at 7 to 14 days after birth, there is no big difference in hemodynamic indexes, so the hemodynamic monitoring with USCOM is of some significance, but the changes in hemodynamic indexes in those at 1 to 3 days after birth are not stable, so there is not much significance in the monitoring. Related Articles | Metrics

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Professor Ding Ying's experience in treating renal hematuria in children 2020, 12 (4):  345-348.  doi: 10.3969/j.issn.1674-3865.2020.04.019 Abstract ( 170 )   PDF (549KB) ( 53 )   Save The purpose of this paper is to introduce Professor Ding Ying's experience in the treatment of renal hematuria in children. Professor Ding Ying summarize the pathogenesis of the disease into three aspects: "heat, blood stasis and deficiency". The disease mainly attacks the kidney and bladder, the heatevil is concentrated in the lower Jiao, disturbing the blood collaterals, and blood overflow is the key to the occurrence of the disease. Yin deficiency with internal heat is the most common clinical syndrome of the disease, and blood stasis is the pathological state throughout the whole course of the disease. At the same time, based on the theory of "collateral disease", it is believed that the stagnation of kidney collaterals is the root cause of difficult recovery of renal hematuria. In terms of treatment, with nourishing Yin and clearing heat, activating blood circulation and dredging collaterals as the treatment principle, Professor Ding creates "Qingre Zhixue prescription" and "Wuteng Tongluo Yin" by herself, which are modified according to the syndrome, and the curative effect is very good. Related Articles | Metrics

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Clinical effect of repeated transcranial magnetic stimulation as auxillary intervention for children with developmental delay 2020, 12 (4):  349-353.  doi: 10.3969/j.issn.1674-3865.2020.04.020 Abstract ( 343 )   PDF (511KB) ( 51 )   Save Objective To observe the clinical effect of repeated transcranial magnetic stimulation combined with comprehensive rehabilitation training on children with global development delay． Methods A total of 82 children with global development delay were included in the study, who were diagnosed in our hospital and received rehabilitation treatment from Oct. 2018 to Dec. 2019.They were divided into two groups according to whether the children cooperated and whether their families agreed to receive repeated transcranial magnetic stimulation: the observation group(n=45) and the control group(n=37). The two groups of children were evaluated by Gesell development scale and on S-S language development retardation before and after 3 months of treatment, and they also received comprehensive rehabilitation training. The observation group was treated with repeated transcranial magnetic stimulation in addition to comprehensive rehabilitation treatment. The changes in Gesell development scale and S-S language development scores were compared differences in clinical effect were compared between the two groups and among children with different degree of disease and at different age in the observation group. Results Gesell development scale scores on adaptability, fine motion ability, language and social ability and S-S language development scores of the two groups were significantly higher after treatment than before treatment, and the scores of the observation group were higher than those of the control group（P<0.05). The total effective rate of the observation group was significantly higher than that of the control group, and there was statistical difference（P<0.05).In the observation group, the total clinical effective rate of the mild cases and the 3 to 4 years old children was significantly higher than the moderate and severe cases and the 4.1 to 5 years old children in Gesell development scale evaluation and S-S language developmental delay evaluation, and there was statistical difference（P<0.05). Conclusion Repeated transcranial magnetic stimulation can improve the cognition and language ability of children with global developmental delay, and in the children at young age and with mild condition, the effect is especially significant. Related Articles | Metrics

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Cohort study on 1 010 children with Henoch-Schonlein purpura receiving different treatment programs 2020, 12 (4):  353-356.  doi: 10.3969/j.issn.1674-3865.2020.04.021 Abstract ( 186 )   PDF (445KB) ( 60 )   Save Objective To investigate the effect of the ladder treatment with traditional Chinese and western medicine in the prevention of early renal injury of Henoch-Schonlein purpura(HSP). Methods A total of 1 010 children with HSP from January 2014 to January 2015 were collected, and were divided into program 1(731 cases) and program 2(279 cases). Different programs were adopted for the ladder treatment. By cohort study, renal injury rates were compared in treatment, abdominal pain, and clinical typing. Results (1)The rate of renal damage after treatment was 13.82%(101/731) and 18.64%(52/279) for program 1 and program 2,respectively, and there was no statistical difference between the two programs(P>0.05).The rate of mild+moderate renal damage was 90.1%(91/101) for program 1, which was higher than that for program 2（76.9%,40/52）(P<0.05); the degree of renal damage for program 1 was lower. The duration of renal involvement in program 1 was （52.48±31.44）d, and it was （40.39±27.18）d in program 2, the difference being statistically significant(P<0.05).(2)In the 1 010 HSP children, 462 had abdominal pain,87(18.83%) had renal damage within 3 months, and the rate of renal damage in the children with ,moderate and severe abdominal pain was higher than in those with mild pain, and there was statistical difference(P<0.05). The rate of renal damage was 19.61% (41/209) in the abdominal type and 18.18% (46/253) in the mixed type, which was higher than that in the skin type(11.16%,24/215）,the difference being statistical(P<0.05). Conclusion (1)Both of the two kinds of programs can reduce the rate of renal damage in HSP, and the combination ladder treatment of traditional Chinese medicine with western medicine is effective in the prevention of renal damage. (2)Renal damage is more likely to occur in children with abdominal-type and mixed-type HSP, and the more severe the abdominal pain, the higher the rate of renal damage. Related Articles | Metrics

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Clinical and genetic analysis of a child with congenital disorder of glycosylation with new mutations of PMM2 gene 2020, 12 (4):  357-361.  doi: 10.3969/j.issn.1674-3865.2020.04.022 Abstract ( 288 )   PDF (738KB) ( 86 )   Save This article reports the clinical features of one case of congenital disorders of glycosylation caused by new mutations of the PMM2 gene and the features of PMM2 gene mutation(PMM2-CDG). The child was a 9-month old girl who presented with psychomotor retardation, abnormal liver enzyme, large ears, esotropia of left eye and hypermyotonia. Two heterozygous mutation points in the child's PMM2 gene was found by Sanger sequencing: c.430T> C (p.F144L) in exon 5 and c.556G＞A（p.G186R） in exon 7.The former mutation came from her father and was a known hot-pathogenic mutation, and the latter came from her mother and was a novel mutation unreported. PMM2-CDG should be considered at the presence of multiple organ damage of unknown causes, especially in infants and young children, which is combined with general developmental delay, neurological disease, liver damage, eye abnormalities, and ear abnormalities, etc. The PMM2 gene test is beneficial to accurate diagnosis, The outcome can be evaluated based on the mutation site. Related Articles | Metrics

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Clinical observation on the treatment of asthma associated with mycoplasma pneumoniae infection by integrated traditional Chinese and western medicine 2020, 12 (4):  362-365.  doi: 10.3969/j.issn.1674-3865.2020.04.023 Abstract ( 151 )   PDF (440KB) ( 36 )   Save Objective To observe the clinical effect of integrated traditional Chinese and western medicine on mycoplasma pneumoniae infection-related wheeze. Methods June 2017 to May 2019 Seventy-two children with Mycoplasma Pneumoniae infection-related wheeze treated in the pediatric clinic of Cenxi Hospital of Traditional Chinese Medicine.They were randomly divided into observation group and control group with 36 cases in each group.The control group was treated with Azithromycin and nebulized budesonide,The observation group was treated with Azithromycin and Maxing Erchen decoction,14 days as a course of treatment. Results Treatment for 14 days,the total effective rate of the observation group was 94.4% respectively,higher than the control group 72.2%,the differences was statistically significant(P<0.05).After treatment,the symptoms of asthma and cough disappeared or alleviated in a shorter time in the observation group than in the control group,the difference was statistically significant(P<0.05).During the 3-month followup period,the frequency of lower respiratory tract infection or asthma in the observation group was less than that in the control group,the difference was statistically significant(P<0.05). Conclusion Clinical signs and symptoms of integrated traditional Chinese and Western medicine in effectively relieving mycoplasma Pneumoniae infection-related asthma,the clinical effect is more ideal. Related Articles | Metrics

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Application of evidence-based nursing in the management of children with asthma 2020, 12 (4):  365-368.  doi: 10.3969/j.issn.1674-3865.2020.04.024 Abstract ( 131 )   PDF (433KB) ( 62 )   Save Objective To explore the application value of evidence-based nursing in the management of childhood asthma. Methods Sixty children with bronchial asthma admitted to our hospital from August 2018 to July 2019 were randomly divided into control group(30 cases) and observation group(30 cases). The control group received routine nursing, while the observation group received evidence-based nursing intervention on the basis of routine nursing. Observe the effects of two kinds of nursing methods on the remission time of symptoms in children with bronchial asthma, parents' understanding of the incidence of asthma and follow-up observation. Results The time of symptom relief, parents' understanding of asthma, degree of acceptance and satisfaction with nursing methods in the observation group were significantly higher than those in the control group, and the difference was statistically significant(P<0.05). Conclusion Evidence-based nursing can effectively improve the treatment effect, reduce asthma attacks, improve the satisfaction of the family members of children with nursing work, and shorten the hospitalization time of children, so it is worthy of clinical promotion. Related Articles | Metrics