Abstract: Objective
To observe the clinical characteristics and prognosis of children with late-onset GBS pyemia， and analyze the factors influencing the prognosis of patients.
Methods
A total of 102 children with GBS pyemia treated in our hospital from June 2014 to October 2017 were selected as the research subjects; according to the type of disease, they divided into early-onset group(48 cases) and late-onset group(54 cases). Observe the difference between the two groups of children in the clinical manifestations and laboratory indexes. Compare the incidence of complications and prognosis between the two groups, and analyze the factors influencing the prognosis of patients.
Results
The incidence rate of fever or hypothermia, shortness of breath, convulsions, apnea, jaundice and pneumonia in late-onset group was  significantly higher than that in the early-onset group, the difference having statistical significance (P<0.05). The Index of WBC, CRP, IL-6 and TNF-αlevel in late onset group were significantly higher than those in the early-onset group, while PLT was lower, the difference being statistically significant(P<0.05). The complication rate of purulent meningitis, NEC, MOF septic shock and DIC in late-onset group was significantly higher than in the early-onset group, the difference being statistically significant(P<0.05). The cure rate of late-onset group(46.3%,25/54) was significantly lower than that in the early-onset group(87.5%,42/48)(P<0.05)；mortality rate was significantly higher in late-onset group(31.5%,17/54) than in the early-onset group(8.3%,4/48)(P<0.05); GBS was the risk factor of the death of children(P<0.05).
Conclusion
The clinical manifestations of late-onset GBS pyemia is serious, with high mortality and poor prognosis.

Key words: Pyemia, CytokineGBS, Complication