ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (5): 394-400.doi: 10.3969/j.issn.1674-3865.2019.05.008

• 临床研究 • 上一篇    下一篇

培土生金法治疗儿童哮喘缓解期的Meta分析与系统评价

李丽香,张任攀,张静蓉,陈四文   

  1. 350122 福州,福建中医药大学2018级中医儿科学专业研究生(李丽香,张任攀),2017级中医儿科学专业研究生(张静蓉);361009福建 厦门,福建中医药大学附属厦门中医院(陈四文)
  • 出版日期:2019-11-01 发布日期:2019-11-08
  • 通讯作者: 陈四文,E-mail:1317103916@qq.com
  • 作者简介:李丽香(1994-),女,福建中医药大学2018级硕士研究生在读。研究方向:小儿呼吸系统、神经系统的中医临床研究
  • 基金资助:
    2018年厦门市医疗卫生项目(3502Z20189059)

Method of reinforcing earth to generate metal for asthma in remission in children: a systematic review and Meta-analysis

LI Lixiang, ZHANG Renpan, ZHANG Jingrong, CHEN Siwen   

  1. Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
  • Online:2019-11-01 Published:2019-11-08

摘要:
目的
系统评价培土生金法治疗儿童哮喘缓解期的有效性。
方法
由两位独立评价者利用计算机全面检索CNKI、Wanfang、CMB、PubMed、Cochrane数据库,纳入培土生金方药与西药治疗儿童哮喘缓解期疗效的临床随机对照试验。检索时限为建库至2019年1月1日。对纳入的数据采用RevMan 53软件对文献进行Meta分析。
结果
纳入21个RCT试验,共1 483例患者。Meta分析结果示:培土生金方药在提高总有效率[RR=1.25,95%CI(1.17,1.32),P<0.000 01];减少发作次数[WMD=-0.65,95%Cl(-0.83,-0.46),P<0.000 01];提高中医证候积分[SMD=-1.44,95%CI(-1.81,-1.07),P<0.000 01];改善肺功能、生化指标条目方面均优于西药。
结论
培土生金方药治疗儿童哮喘缓解期(肺脾气虚证)疗效明显优于西药,疗效肯定。但现有的文献质量偏低,仍需更多高质量研究来验证结论。

关键词: 哮喘, 培土生金法, 缓解期, 儿童, Meta分析

Abstract: Objective
To systematically assess the effectiveness of the Method of Reinforcing Earth to Generate Metal (MREGM) for the treatment of asthma in remission in children.
Methods
Some databases including CNKI, Wanfang, CMB, PubMed and Cochrane were searched by two independent researchers for the related clinical randomized controlled trials(RCTs) about the MREGM and western medicines for treating asthma in remission. The search time was from the inception of the databases to January 1st, 2019. Metaanalysis was performed to analyze all the included data by using Review Manager 5.3.
Results
A total of 21 RCTs involving 1 483 patients were included in this meta-analysis. The results demonstrated that MREGM had better effects in increasing the total effective rates[RR=1.25, 95%CI(1.17, 1.32), P<0.000 01], decreasing the number of asthmatic attack[WMD = -0.65, 95%CI(-0.83, -0.46),P<0.000 01] ,increasing the TCM syndrome scores[SMD =-1.44, 95%CI(-1.81, -1.07),P<0.000 01], and improving pulmonary function and biochemical indexes than western medicine.
Conclusion
MREGM is more effective than western medicine in the treatment of childhood asthma in remission(lung-and-spleen-qi deficiency syndrome). However, due to the low quality of the trials included in this study, more high-quality RCTs are needed to further verify this conclusion.

Key words: Asthma, Method of Reinforcing Earth to Generate Metal, Remission period, Children, Meta-analysis