ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2026, Vol. 18 ›› Issue (2): 157-167.doi: 10.20274/j.cnki.issn.1674-3865.2026.02.013

• 小儿中药应用研究 • 上一篇    下一篇

基于数据挖掘探讨许华教授干预造血干细胞移植后患儿经验

黄宝仪1,2, 易立琛3, 陈亚宾1,2, 许华1,2()   

  1. 510405 广州,广州中医药大学第一附属医院儿科、广东省中医临床研究院(黄宝仪,陈亚宾,许华)
    510006 广州,广州中医药大学针灸康复临床医学院(易立琛)
  • 收稿日期:2025-09-18 修回日期:2025-11-11 出版日期:2026-04-25 上线日期:2026-04-25
  • 通讯作者: 许华 E-mail:xuhua212@126.com
  • 作者简介:黄宝仪(1997-),女,医学博士,医师。研究方向:中医药防治儿童血液病、脾胃病
  • 基金资助:
    广东省许华名中医传承工作室建设项目(粤中医办函〔2023〕108号);国家中医优势专科建设项目(儿科)(国中医药医政函〔2024〕90号);广州市科技计划项目(2023A04J1172);广州中医药大学许华教学名师工作室(广中医校办〔2020〕75号)

Exploring Professor Xu Hua's experience in treating pediatric patients post-hematopoietic stem cell trans⁃plantation based on data mining

Baoyi HUANG1,2, Lichen YI3, Yabin CHEN1,2, Hua XU1,2()   

  1. 1.The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China
    2.Guangdong Clinical Research Academy of Chinese Medicine,Guangzhou 510405,China
    3.Guangzhou University of Chinese Medicine,Guangzhou 510405,China
  • Received:2025-09-18 Revised:2025-11-11 Published:2026-04-25 Online:2026-04-25
  • Contact: Hua XU E-mail:xuhua212@126.com
  • Supported by:
    Guangdong Provincial Xu Hua Famous Traditional Chinese Medicine Inheritance Studio Cons?truction Project

摘要:

目的 通过数据挖掘技术探讨许华教授干预造血干细胞移植(HSCT)后患儿的中药用药规律,总结其临证经验,为推广中医药在儿童HSCT领域的临床应用提供参考。 方法 收集2021年1月1日至2024年12月12日许华教授在广州中医药大学第一附属医院儿科门诊或儿科住院部诊治HSCT后患儿的处方,通过中药用药频次、剂量、属性分析,中药关联规则分析、构建中药复杂网络、核心中药聚类分析、配伍中药社团分析等多种数据挖掘技术,客观呈现许华教授的用药规律和临证经验。 结果 共纳入处方230首,中药177味,所用中药四气以温、平、微温性为主,五味以甘、辛、苦味为多,归经以脾经、肺经和胃经为主。两中药共现频率位列前5的关联中药有法半夏-茯苓、麸炒白术-茯苓、麸炒白术-法半夏、陈皮-麸炒白术、陈皮-茯苓,置信度达100%的关联中药有蜜麻黄-苦杏仁、前胡-苦杏仁、龙骨-牡蛎、毛冬青-蜜麻黄、毛冬青-苦杏仁、蛤壳-法半夏。获得6类核心中药处方,类别1(太子参、茯苓、麸炒白术、木香、葛根、广藿香、法半夏、陈皮、焦山楂、甘草片)所含中药用药频次位居前列。 结论 许华教授干预HSCT后患儿以健运脾气为主,配合益气养阴、调补肺肾,以及化痰、祛瘀,喜用药食同源之品,助力HSCT后患儿气血津液化生及运行,使多脏腑功能失调甚至虚衰得到改善。

关键词: 造血干细胞移植, 中医药, 名医经验, 用药规律, 数据挖掘, 儿童

Abstract:

Objective To explore the patterns of traditional Chinese medicine (TCM) usage in Professor Xu Hua's interventions for pediatric patients post-hematopoietic stem cell transplantation (HSCT) through data mining techniques, summarize her clinical experience, and provide references for promoting the clinical application of TCM in the field of pediatric HSCT. Methods Prescriptions from pediatric patients treated by Professor Xu Hua at the First Affiliated Hospital of Guangzhou University of Chinese Medicine (outpatient or inpatient) between January 1, 2021, and December 12, 2024, were collected. Various data mining techniques, including frequency, dosage, and property analysis of TCM, association rule analysis, complex network construction, core TCM clustering analysis, and community analysis of compatible TCM, were employed to objectively present Professor Xu Hua's medication patterns. Results A total of 230 prescriptions involving 177 TCM herbs were included. The four natures of the herbs were predominantly warm, neutral, and slightly warm, while the five flavors were mainly sweet, pungent, and bitter. The meridians most frequently targeted were the spleen, lung, and stomach. The top five herb pairs with the highest co-occurrence frequency were Pinellia ternata(Fabanxia)-Poria(Fuling), stir-fried Atractylodes macrocephala(Fuchaobaizhu)-Poria(Fuling), stir-fried Atractylodes macrocephala(Fuchaobaizhu)-Pinellia ternata(Fabanxia), tangerine peel(Chenpi)-stir-fried Atractylodes macrocephala(Fuchaobaizhu), and tangerine peel(Chenpi)-Poria(Fuling). Herb pairs with 100% confidence included honey-fried Ephedra(Mimahuang)-bitter apricot kernel(Kuxingren), Peucedanum praeruptorum(Qianhu)-bitter apricot kernel(Kuxingren), dragon bone(Longgu)-oyster shell(Muli), Ilex pubescens(Maudongqing)-honey-fried Ephedra(Mimahuang), Ilex pubescens(Maudongqing)-bitter apricot kernel(Kuxingren), and clam shell(Haqiao)-Pinellia ternata(Fabanxia). Six categories of core TCM prescriptions were identified, with Category 1(comprising Pseudostellaria heterophylla(Taizishen), Poria(Fuling), stir-fried Atractylodes macrocephala(Fuchaobaizhu), Aucklandia lappa(Muxiang), Pueraria lobata(Gegen), Pogostemon cablin(Guanghuoxiang), Pinellia ternata(Fabanxia), tangerine peel(Chenpi), charred hawthorn(Jiaoshanzha), and licorice slice(Gancaopian) containing the most frequently used herbs. Conclusion Professor Xu Hua's interventions for pediatric patients post-HSCT primarily focus on strengthening the spleen's function, complemented by replenishing qi and nourishing yin, regulating the lung and kidney, resolving phlegm, and dispelling stasis. She prefers using herbs that serve both medicinal and dietary purposes, aiding in the generation and circulation of qi, blood, and body fluids in post-HSCT children, thereby improving the dysfunction or deficiency of multiple organs.

Key words: Hematopoietic stem cell transplantation, Traditional Chinese medicine, Famous physician experience, Medication patterns, Data mining, Child

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