ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (5): 450-453.doi: 10.3969/j.issn.1674-3865.2015.05.015

• 临床研究 • 上一篇    下一篇

大剂量维生素C辅助治疗小儿急性肾小球肾炎疗效观察

王勇,方红星,孙雅军,刘惠敏   

  1. 475000 河南 开封,开封市儿童医院内科六病区
  • 出版日期:2015-10-25 发布日期:2015-11-19
  • 作者简介:王勇(1972-),男,副主任医师。研究方向:小儿呼吸和泌尿系统疾病的诊断与治疗,E-mail:zhyputong@163.com。

Effect observation of large-dose vitamin C in treating acute glomerulonephritis in children

WANG Yong, FANG Hongxing, SUN Yajun, LIU Huimin   

  1. Children's Hospital of Kaifeng City,Kaifeng 475000,China
  • Online:2015-10-25 Published:2015-11-19

摘要:
目的
:观察大剂量维生素C辅助治疗小儿急性肾小球肾炎的临床疗效。
方法:80例急性肾小球肾炎患儿按治疗方法不同分为对照组与观察组各40例。对照组采用常规西药方法进行治疗,观察组在对照组基础上增加采用大剂量维生素C进行治疗,连续治疗4周,观察两组患者的水肿消退、血沉、尿常规、补体等变化及治疗效果。
结果:两组总有效率比较差异无统计学意义(P>0.05);观察组痊愈率为70.0%(28/40),高于对照组47.5%(19/40),差异有统计学意义(P<0.05)。观察组患儿在水肿消退、血压、血沉、尿常规及补体方面恢复正常时间均明显低于对照组,差异有统计学意义(P<0.05)。
结论:大剂量维生素C在小儿急性肾小球肾炎的治疗中发挥重要辅助作用,值得大力推广应用。

关键词: 肾小球肾炎/治疗, 维生素C/治疗应用, 儿童

Abstract:
Objective:
To investigate the clinical effect of large-dose vitamin C in treating acute glomerulonephritis.
Methods:Eighty cases of acute glomerulonephritis were divided into control group and observation group, 40 cases in each group. The control group was given conventional western medicine and observation group was given large-dose vitamin C in addition to the conventional western medicine. After 4 weeks of treatment, observe the extinction of edema,blood sedimentation, routine urine test and complement change of the two groups.
Results:Total effective rate of the two groups had no statistical significance(P>0.05). Cure rate of observation group was 70.0%(28/40), higher than control group(47.5%,19/40), the difference being statistically significant(P<0.05). Extinction of edema, blood sedimentation, routine urine test and complement of observation group had shorter recovery time than control group, the difference being statistically significant(P<0.05).
Conclusion:Large-dose vitamin C plays an important role in the treatment of acute glomerulonephritis. It is worthy of wide application.

Key words: glomerulonephritis/treatment, vitamin C/treatment application, children

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