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Experience of Prof.She Jilin in treating children with Tourette syndrome QIN Shengjuan,WANG Chengjiao,SHE Jilin Chinese Pediatrics of Integrated Traditional and Western Medicine    2018, 10 (1): 90-92.   DOI: 10.3969/j.issn.1674-3865.2018.01.028 Abstract （1077）      PDF（pc） （482KB）（287）       Knowledge map    Save This paper briefly introduces Prof. She Jilin’s experience in the treatment of children with Tourette syndrome from the aspects of etiology, pathogenesis, treatment principles and prescriptions. At onset stage, the disease manifests as "Shi Zheng"(with the symptom of high fever, no sweat, abdominal distension, etc.), and the treatment aims to calm the liver wind, clear away heart-fire, nourish Yin and clear the heat. At remission stage, the disease manifests as "Xu Zheng"(deficiency syndrome), and the treatment focuses on invagrating spleen, nourishing Yin and Yang, calming liver wind and nourishing liver and kindey. Meanwhile, Prof. She also pays attention to psychological behavior intervention. Prof. She thinks that this disease in children most often is related to allergy, which makes more attacks at the turn of seasons and becomes more severe after catch a cold. During treatment, anti-allergic medicine should be given and pay attention to the regulation of lung, in order to strengthen the children's physical condition and improve the allergic situation of the children. Related Articles | Metrics

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Observation on the results of comprehensive nursing intervention in autumn diarrhea in infants and young children WANG Hongling Chinese Pediatrics of Integrated Traditional and Western Medicine    2015, 7 (5): 534-537.   DOI: 10.3969/j.issn.1674-3865.2015.05.048 Abstract （480）      PDF（pc） （571KB）（1346）       Knowledge map    Save ObjectiveTo observe the clinical effect of comprehensive nursing intervention in autumn diarrhea in infants and young children.MethodsTotally 120 cases of autumn diarrhea in infants were randomly divided into observation group and control group with 60 cases in each group. In addition to conventional symptomatic treatment，routine nursing was given to the control group，while comprehensive nursing was given to the observation group. The total efficiency, satisfaction rate, length of hospital stay and costs were compared.ResultsThe satisfaction rate of children in observation group was 98.3%(59/60), and the total effective rate was 96.7%(58/60), which were significantly higher than 83.3%(50/60) and 83.3% (50/60) in the control group，the difference being statistically significant(P＜0.05); and in the observation group hospitalization costs were lower and hospital stay was shorter than the control group, the difference being statistically significant(P＜0.05).Conclusion Comprehensive nursing intervention can improve overall efficacy in children with diarrhea who receive symptomatic treatment, and it can also improve nursing satisfaction, which should be introduced. Related Articles | Metrics

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Chinese Pediatrics of Integrated Traditional and Western Medicine    2012, 4 (3): 234-235.   Abstract （162）      PDF（pc） （286KB）（161）       Knowledge map    Save Related Articles | Metrics

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Study on the relativity of the the related trace elements in serum with 25-(OH)D3 HE Yi,ZHONG Yan,ZHU Sha,DING Dawei Chinese Pediatrics of Integrated Traditional and Western Medicine    2016, 8 (5): 536-538.   DOI: 10.3969/j.issn.167-3865.2016.05.026 Abstract （407）      PDF（pc） （272KB）（222）       Knowledge map    Save Objective ：To measure the content of 25-(OH)D3(25-hydroxylase catalytic system generated ossification diol) in the blood serum of the children of different ages, and to probe into the relativity of 25-(OH)D3 with BAKP(bone alkaline phosphatase) and trace elements. Methods： Totally 382 cases of children were chosen, who took routine physical examination in the health care center of our hospital, as the research object.Divide the children into 5 groups according to their different ages:≤1，＞1～3，＞3～5，＞5～7 and ＞7～12. Detect the concentration of serum 25-(OH)D3, the serum BAKP and some trace elements, such as the Cu,Zn,Fe and Mg by using enzyme-linked immune testing method. Results： Children of all ages were obviously in lack of 25-(OH)D3.By using the Pearson correlation analysis, it was shown that the relativity between Zn and BAKP,Cu，between Fe and BAKP,Cu,Zn，between Mg and Cu,Z,Fe was very obvious(P<0.05).There was relativity between 25-(OH)D3 and BAKP(P<0.05).But there was no obvious relativity between 25-(OH)D3 and trace elements such as Cu,Zn,Fe and Mg(P>0.05). Conclusion： Children of 0～12 years old have different degree of 25-(OH)D3 deficiency, which is especially serious in the children of 0～3 years old.The relativity analysis shows that there is connection between 25-(OH)D3 and BAKP, but there is no connection between 25-(OH)D3 and such trace elements as Cu,Zn,Fe and Mg.Taking Zn and Fe can help improve the BAKP content,which is very beneficial to children′s health. Related Articles | Metrics

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Analysis of epidemiology and drug resistance in 200 children with mycoplasma pneumonia WU Juntian, ZHANG Jiabin, ZHOU Shuming Chinese Pediatrics of Integrated Traditional and Western Medicine    2017, 9 (2): 172-174.   DOI: 10.3969/j.issn.1674-3865.2017.02.027 Abstract （440）      PDF（pc） （312KB）（266）       Knowledge map    Save Objective：To analyze the epidemiology and drug resistance in 200 children with mycoplasma pneumonia and to provide reference for clinical treatment. Methods：Throat swabs were collected from 652 children with respiratory infection in out-patient department in our hospital. The swabs were cultured to detect MP. The MP infection was recorded according to seasons, ages and gender. The drug resistance to multiple antibiotics was detected. Results：MP culture showed that the positive rate was 30.67%;the infection rates in different seasons had differences, and the infection rate was the lowest in winter(15.00%), which was significantly lower than that in other seasons(P<0.05),and it was the highest in fall(38.50%);the infection rate in male children was slightly lower than the female patients(30.02% vs 31.80%,P>0.05);the infection rates in different age groups were significantly different(P<0.05):0-1-year-old group was higher than the 6-14-year-old group(P<0.008 3). Susceptibility test showed that drug resistance rates were significantly different to different antibiotics(P<0.05).ERY and ROX resistance rates were significantly higher than AZI(P<0.05). Conclusion：MP infection in children with respiratory tract infection has high proportion, which is age-related; it doesn't often occur in winter, and in the clinical treatment MP throat swab culture and drug sensitivity testing are required to guide the clinical administration. Related Articles | Metrics

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Effect of Xiyanping injection on expression of Bcl-2/Bax protein in adenovirus-infected Hep-2 cells ZHANG Xiuying, WANG Xuefeng, WANG Siyuan, PING Jing. Chinese Pediatrics of Integrated Traditional and Western Medicine    2017, 9 (2): 96-99.   DOI: 10.3969/j.issn.1674-3865.2017.02.002 Abstract （430）      PDF（pc） （474KB）（261）       Knowledge map    Save Objective:To explore mechanism of antiviral mechanism of Xiyanping injection in vitroby invstigating influence of  Xiyanping injection on expression of Bcl-2/Bax protein in adenovirus-infected Hep-2 cells. Methods:The Hep-2 cells were infected with adenovirus, which were interfered with high, medium and low dose of Xiyanping injection and ribavirin. Then expressions of Bcl-2/Bax protein were measured by immunohistochemistry. Results:The expressions of Bax protein in model group were significantly higher than normal groups（P<0.05）.The expression of Bax protein in all Xiyangping groups and ribavirin control group was lower than that of model group, and it was much lower in the high-dose Xiyanping group and ribavirin control group than in the model group(P<0.05). The expressions of Bal-2 protein in different groups had no significant difference（P>0.05）. ConclusionXiyanping injection can kill ADV by suppressing the expressions of Bax protein. The high-dose Xiyanping injection is better than others. Related Articles | Metrics

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Biostime probiotics combined with compound Huangbai solution in treatment of childhood eczema: an observation on the efficacy LI Fangfang Chinese Pediatrics of Integrated Traditional and Western Medicine    2017, 9 (2): 121-123.   DOI: 10.3969/j.issn.1674-3865.2017.02.009 Abstract （762）      PDF（pc） （327KB）（348）       Knowledge map    Save Objective：To investigate the clinical efficacy of biostime probiotics combined with compound Huangbai solution in the treatment of eczema in children． Methods：Totally 82 children with eczema treated in our hospital from Aug. 2014 to Jan. 2016 were selected as the subjects, and they were randomly divided into two groups: observation group(A) and control group(B),41 children in each group. Group A was given biostime probiotics combined with external treatment of Huangbai solution，while Group B was only given external treatment of Huangbai solution．The eczema area, EASI scores and the clinical curative effect of two groups were observed after two weeks of treatment． Results：After the treatment of one week and two weeks, the EASI scores were statistically different between the two groups(P<0.05),and the curative effect of Group A was better than that of Group B. The total effective rate in Group A and B was 92.1% and 65.7%, respectively and the difference was statistical(P<0.05)． Conclusion：For children with eczema, the treatment of oral biostime probiotics combined with compound Huangbai solution for external use can achieve significant effect． Related Articles | Metrics

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Effects of Anti-disease Sachet(a type of Zhuang medicine) on the secretion of respiratory sIgA and IgG in Qi-deficiency mice WANG Lining，ZHANG Yixian，DENG Puyuan，LI Jie，ZHOU Zhining Chinese Pediatrics of Integrated Traditional and Western Medicine    2018, 10 (1): 6-8.   DOI: 10.3969/j.issn.1674-3865.2018.01.002 Abstract （572）      PDF（pc） （436KB）（323）       Knowledge map    Save Objective To study the effect of Anti-disease Sachet(a type of Zhuang medicine) on local immune function in Qi-deficiency mice, and to explore its mechanism in prevention and treatment of recurrent respiratory tract infection. Methods A total of 24 SPF mice of Kunming species were chosen(male and female), whose body mass was 18-22 g. They were randomly divided into four groups: blank group, model group, incense module group and sachet group, with 6 mice in each group. They were intervened by Anti-disease Sachet for 4 weeks, and at the fourth week, Qi-deficiency model was established; after that, ELISA was used to determine the concentration of sIgA and IgG in the alveolar lavage fluid. Results There was no statistical difference in sIgA in alveolar fluid between model group and sachet group(P>0.05). The sIgA in alveolar fluid of mice was significantly higher in sachet group than in blank group and model group, and there was statistical difference(P<0.05). There was no statistical difference in IgG in alveolar fluid of mice among the four groups(P>0.05). Conclusion Anti-disease Sachet(a type of Zhuang medicine) is effective in improving respiratory immune function, so it can be used to prevent recurrent respiratory tract infection in children. Related Articles | Metrics

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Chinese Pediatrics of Integrated Traditional and Western Medicine    2015, 7 (4): 292-297.   DOI: 10.3969/j.issn.1674-3865.2015.04.002 Abstract （580）      PDF（pc） （751KB）（389）       Knowledge map    Save Related Articles | Metrics

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Nutritional status and influencing factors of 389 preschool children in Dadong District of Shenyang City LI Jinghui， REN Gang， ZHAN Jie， LI Jing， MA Lijie Chinese Pediatrics of Integrated Traditional and Western Medicine    2017, 9 (4): 340-342.   DOI: 10.3969/j.issn.1674-3865.2017.04.021 Abstract （459）      PDF（pc） （337KB）（365）       Knowledge map    Save Objective To investigate the nutritional status of preschool children in 4 kindergartens in Shenyang City， and to provide reliable for nutritional intervention in preschool children. Methods Height and weight were measured and Kaup index was cakulated in 389 preschool children in Dadong District. The food types and eating habits were surveyed by questionnaires. Analyze the relationship between the related factors and the nutritional status of children. Results In 389 cases of children the average Kaup index was 16.30±2.07， and it was 16.45±1.87 in the boys and 16.12±2.27 in the girls；the index was normal in 346 cases. There were 41 lean cases and 2 cases a little fat. The questionnaires showed that the causes of malnutrition in children were mainly: hating fish， meat， eggs， soybean， etc.，being picky eaters，eating slowly，not having three meals on time，and wrong idea about nutrition in parents. Conclusion Some preschool children in Dadong District of Shenyang city have the phenomenon of malnutrition. Related Articles | Metrics

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Research progress of animal model of anorexia LI Han, XIONG Lei, CHEN Bojun,XIE Yuhuan,ZHOU Yingqing, HUANG Yucheng Chinese Pediatrics of Integrated Traditional and Western Medicine    2017, 9 (1): 15-18.   DOI: 10.3969/j.issn.1674-3865.2017.01.004 Abstract （565）      PDF（pc） （556KB）（319）       Knowledge map    Save Anorexia is a common disease of unusual ingestive behavior of human, and building animal model is helpful to the intensive study of this disease. The related report on anorexia modeling method is little in China, and there is insufficiency of animal model which is used in anorexia experimental study, which is related to heredity, mentality, physiology, environment and other factors. This paper makes an analysis on the common anorexia modeling method both at home and abroad and its advantage and disadvantage, and points out the current problems which exist in the process of developing and evaluating the TCM animal model. Related Articles | Metrics

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Diagnosis and treatment of 839 cases of intussusception in children XU Feng，GUO Chunna Chinese Pediatrics of Integrated Traditional and Western Medicine    2016, 8 (5): 517-519.   DOI: 10.3969/j.issn.167-43865.2016.04.019 Abstract （984）      PDF（pc） （329KB）（208）       Knowledge map    Save Objective ：To study the clinical manifestations and diagnosis and treatment of intussusception in children. Methods： Analysis the clinical data of 839 cases of intussusception in children diagnosed by B ultrasound between Jan. 2013 and Jan. 2016. Results： Among the 839 cases, 599 were male and 240 were female, the ratio of male to female being 2.5∶1. Air enema reduction was successful in 758 cases, the success rate being 90.3%; 81 children were successfully treated by surgery; intussusception relapse occurred in 86 cases, with the recurrence rate being 10.2%, who received air enema reduction again and 85 were successfully treated, the success rate being 98.8%. In the pathological aspect: there were 805 cases of primary intussusception, 34 cases of secondary one(polyps in 5 cases, Meckel's diverticulum in 20 cases, intestinal duplication in 3 cases and allergic purpura in 6 cases). Intestinal necrosis was found in 33 cases during surgery, which was confirmed by pathology after surgery. Conclusion： Air enema reduction is an effective treatment for children with intussusception. Timely surgery is recommended in case of reduction failure in order to avoid intestinal necrosis. For the children with repeated intussusception, there may be the possibility of abnormal anatomy of ileum and cecum and secondary intussusception. Intestinal necrosis is related to the type and length of time of intussusception. Related Articles | Metrics

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Research progress of TCM treatment for functional abdominal pain in children MA Jinmei，CHEN Lu Chinese Pediatrics of Integrated Traditional and Western Medicine    2017, 9 (4): 293-295.   DOI: 10.3969/j.issn.1674-3865.2017.04.006 Abstract （684）      PDF（pc） （311KB）（282）       Knowledge map    Save A lot of literatures have shown that western medicine has its limitation in the treatment of functional abdominal pain in children, which is mainly anti-infectious, anti-viral, sedative and anti-allergic treatments. In traditional Chinese medical treatment, there are many ways which by combining the internal with the external therapies, has achieved rapid effect, and also, there is no obvious adverse reaction. For external treatment, there are external application, acupunction, moxibustion, cupping, massage and chiropractic therapy. All these treatments are easy to perform and without side effects, and the compliance in children is comparatively high. However, there has been no consensus on TCM treatment due to the recognition difference, so it is necessary to look for more suitable and more accurate ways and to standardize the process of diagnosis and treatment. Related Articles | Metrics

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Nursing intervention in children with lobar pneumonia GAO Xiaoling Chinese Pediatrics of Integrated Traditional and Western Medicine    2016, 8 (6): 638-640.   DOI: 10.3969/j.issn.1674-3865.2016.06.029 Abstract （316）      PDF（pc） （347KB）（212）       Knowledge map    Save Objective:To observe the effect of two different kinds of nursing intervention on the children with lobar pneumonia. Methods:Eighty cases of children with pneumonia, which were treated in the Fifth People's Hospital of Shenyang from January 2015 to January 2016, were randomly divided into two groups. Thirty-five cases of children with pneumonia in the experiment group received additional nursing intervention, including aerosol inhalation, postural drainage and chest physical therapy on the basis of routine drug treatment, while 45 cases in the control group only received the routine drug treatment. Compare the time that clinical symptoms disappeared, such as fever, asthma, cough and crackles. Nursing effect of two groups were compared. Results:Total effective rate of  nursing in experiment group was 94.3%(33/35),which was higher than that of control group(73.3%, 33/45)（P<0.05）. There were significant differences between the two groups on the disappearance time of crackles and asthma（P<0.05）, but there were no significant differences between the two groups on that of fever and cough（P＞0.05）. Conclusion：Appropriate nursing intervention is beneficial to the rehabilitation of the children with pneumonia. Related Articles | Metrics

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Influencing factors of hyperbilirubinemia in preterm infants MU Huaixin，LI Juan Chinese Pediatrics of Integrated Traditional and Western Medicine    2018, 10 (1): 56-58.   DOI: 10.3969/j.issn.1674-3865.2018.01.016 Abstract （546）      PDF（pc） （325KB）（350）       Knowledge map    Save Objective To study the influencing factors of hyperbilirubinemia in preterm infants. Methods A total of 237 cases of preterm infants under 37 weeks of gestational age diagnosed with hyperbilirubinemia were selected, who received phototherapy in Shengjing Hospital of China Medical University from June 2013 to Dec. 2016, and they were included as the observation group. A total of 142 preterm infants without hyperbilirubinemia hospitalized during the same period were chosen as the control group. Compare the gestational factors of the mothers，  the general condition of the preterm infants and their relationship with the diseases in preterm infants between the two groups. Results The cesarean section rate of observation group was 43.5%（103/237）， the rate of 1 min Apgar score≤7 was 22.8%（54/237）， and the rate of time of first meconium＞24 h was 27.4%（65/237）， all being higher than those of control group（25.4%,11.3% and 17.6%，respectively）， and there was statistical difference（P<0.05）. The incidence rate of acidosis（18.6%，44/237），neonatal sepsis（EOS/LOS）（8.4%,20/237）, neonatal hemolysis disease(5.9%,14/237), and suppurative meningitis(2.53%,6/237) was significantly higher than that of control group(18.3%,0.7%,1.4% and 0.7%, respectively), the difference being statistical(P<0.05). The gestational age of the observation group［(33.8±2.1)weeks］ and the birth weight［(2 259±515)g］ were significantly lower than the control group（P<0.05）. The hemoglobin level［(170±21)g/L］ was higher in the observation group than in control group［(163±22)g/L］(P<0.05). Multi-factor Logistic regression analysis showed that the 1 min Apgar score≤7（OR=8.189，P<0.05）, cesarean section（OR=2.461，P<0.05）， the time of first meconium>24 h（OR=3.214，P<0.05）, neonatal sepsis（EOS/LOS）（OR=45.385，P<0.05）， and high level of hemoglobin（OR=1.024，P<0.05） were the risk factors of hyperbilirubinemia in preterm infants. Conclusion Many perinatal factors can lead to hyperbilirubinemia in the preterm infants. It will reduce the incidence of hyperbilirubinemia in preterm infants to improve delivery technique， detect early and give timely gastrointestinal feeding. Related Articles | Metrics

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Chinese Pediatrics of Integrated Traditional and Western Medicine    2013, 5 (2): 107-109.   DOI: 10.3969/j.issn.1674-3865.2013.02.006 Abstract （229）      PDF（pc） （474KB）（223）       Knowledge map    Save Related Articles | Metrics

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Clinical observation of recombinant human growth hormone in the treatment of growth hormone deficiency and idiopathic short stature in children XIE Wen，HU Hongqing Chinese Pediatrics of Integrated Traditional and Western Medicine    2018, 10 (6): 510-512.   DOI: 10.3969/j.issn.1674-3865.2018.06.016 Abstract （461）      PDF（pc） （295KB）（174）       Knowledge map    Save Objective To observe the clinical effect of recombinant human growth hormone (rhGH) in the treatment of growth hormone deficiency(GHD) and idiopathic short stature (ISS) in children, and to explore the value and safety of IGF-1. Methods A total of 12 GHD children and 7 ISS children diagnosed in Yixing People Hospital from January 2016 to December 2017 were chosen as the research subjects and were treated with rhGH. They were divided into GHD group and ISS group according to the diagnosis. Subcutaneous injection of rhGH at 0.1-0.2 U/（kg·d） was given 30 min before going to bed for 6-7 times each week. The growth rate and IGF-1 were measured before treatment, and at 3 months and 6 months after treatment. The standard deviation integral was calculated, too. Results (1) The average height increase and growth rate in GHD group were significantly higher than those in ISS group, and the difference was statistically significant.(2) The standard deviation integral of IGF-1 in both groups increased significantly, with statistical significance, and the increase in GHD group was significantly higher than that in ISS group. ConclusionRhGH has obvious effect of promoting growth on children with short stature, especially on children with GHD, and IGF-1 is helpful for the evaluation of efficacy and safety. Related Articles | Metrics

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Simultaneous determination of six components in Xiaoer Bushen Gubiao granule by HPLC YANG Hui，PAN Dongming，QI Huanyang，HUANG Yiqi， LUO Youhua， ZHANG Qingling，XUE Zheng， YU Jianer，CHU Kedan Chinese Pediatrics of Integrated Traditional and Western Medicine    2019, 11 (2): 112-116.   DOI: 10.3969/j.issn.1674-3865.2019.02.006 Abstract （382）      PDF（pc） （427KB）（193）       Knowledge map    Save Objective To establish a method for the simultaneous determination of six components (prim-O-glucosylcimifugin，calycosin-7-glucoside， 5-O-methylvisammioside， baicalin， psoralen and angelicin) in Xiaoer Bushen Gubiao granule by HPLC. Methods The chromatographic conditions were determined by high performance liquid chromatography with C18 column (250 mm×4.6 mm，5 μm)，mobile phase being acetonitrile-0.2% formic acid aqueous for solution gradient elution; flow rate was 1.0 mL/min，and column temperature was 30 ℃， injection volume 10 μL; DAD detector was used with the detection wavelength being 254 nm and 280 nm. Results The six components were well separated and showed a good linear relationship with peak area (r≥0.999 0) within their respective concentration ranges. The average sample recovery rates of prim-O-glucosylcimifugin，calycosin-7-glucoside， 5-O-methylvisammioside， baicalin， psoralen and angelicin were 99.89%，101.86%，103.22%，99.59%，98.37%，98.12%，and RSD was 3.84%，2.80%，3.12%，4.29%，4.53% and 4.87%， respectively. Conclusion The method is accurate， simple， reproducible and sensitive. It can be used for the quality control of multi-components in Xiaoer Bushen Gubiao granule. Related Articles | Metrics

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Chinese Pediatrics of Integrated Traditional and Western Medicine    2011, 3 (3): 253-254.   Abstract （216）      PDF（pc） （259KB）（193）       Knowledge map    Save Related Articles | Metrics

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Clinical study of scalp acupuncture combined with transcranial ultrasound therapy and language training for children with mental retardation and language disorder WANG Xue Chinese Pediatrics of Integrated Traditional and Western Medicine    2021, 13 (2): 93-.   Abstract （414）      PDF（pc） （507KB）（421）       Knowledge map    Save Objective：To explore the effect of Scalp acupuncture with transcranial ultrasound therapy combined with language training in the treatment of children with mental retardation and language disorder. Methods：Totally 90 children with mental retardation and language disorder who were admitted to our hospital from June 1,2018 to December 31,2019 were selected as the study subjects. According to the order of admission, they were divided into test group, control group 1 and control group 2,30 cases each. Control group 1 was treated with traditional language cognitive training, Control Group 2 was treated with scalp acupuncture on the basis of language training, and test group was additionally treated with transcranial ultrasound therapy. Results：The intelligence level and language function of 3 groups were improved; the total effective rate of control group 2 was higher than that of control group 1, and the total effective rate of observation group was significantly higher than that of control group 1 and control group 2; all the differences were of statistical significance. Conclusion：Scalp acupuncture with transcranial ultrasound therapy combined with language training is significantly effective in the treatment of children with mental retardation and language disorder. Related Articles | Metrics