ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (6): 479-481.doi: 10.3969/j.issn.1674-3865.2018.06.006

• 专栏 • 上一篇    下一篇

喜炎平注射液治疗小儿细菌性下呼吸道感染的临床研究

陈晓媛，马金海   

  1. 750004 银川，宁夏医科大学总医院儿科
  • 出版日期:2018-12-25 发布日期:2019-03-25
  • 通讯作者: 马金海，E-mail：makhcn@163.com
  • 作者简介:陈晓媛（1990-），女，医学硕士，主治医师。研究方向：小儿呼吸系统疾病的诊治

Clinical research of Xiyanping injection in the treatment of pediatric bacterial lower respiratory tract infection

CHEN Xiaoyuan,MA Jinhai   

  1. Ningxia Medical University Hospital of Pediatrics, Yinchuan 750004，China
  • Online:2018-12-25 Published:2019-03-25

PDF (PC)

105

摘要：
目的
观察喜炎平注射液治疗小儿细菌性下呼吸道感染的临床疗效。
方法选择2015年1月至2016年1月宁夏医科大学总医院儿科收治的下呼吸道感染（痰培养阳性）患儿212例为研究对象，随机分为观察组和对照组各106例。对照组应用抗生素、雾化吸入等常规治疗，观察组在对照组基础上给予静脉滴注喜炎平注射液，疗程7 d。观察两组患儿临床疗效，退热时间、咳嗽缓解时间、肺部体征消失时间、住院时间，C反应蛋白、血沉、白细胞计数和肺功能（潮气呼气峰流速）的恢复情况。
结果观察组临床总有效率为94.3%（100/106），显著高于对照组76.4%（81/106），差异有统计学意义（P<0.05）。治疗5 d后观察组患儿痰培养阳性率为7.3%（15/106），显著低于对照组28.3%(30/106)，差异有统计学意义（P<0.05）。观察组患儿退热时间、咳嗽缓解时间、肺部体征消失时间、住院时间均显著低于对照组，差异有统计学意义（P<0.05）。治疗后观察组C反应蛋白、血沉、白细胞计数均低于对照组，潮气呼气峰流速高于对照组，差异有统计学意义（P<0.05）。
结论喜炎平注射液治疗小儿细菌性下呼吸道感染效果显著。

关键词: 下呼吸道感染, 细菌性, 喜炎平, 儿童

Abstract:
Objective
To observe the clinical effect of Xiyanping injection in the treatment of pediatric bacterial lower respiratory tract infection.
Methods
A total of 212 children treated for lower respiratory tract infection(positive sputum culture) in General Hospital of Ningxia Medical University from Jan. 2015 to Jan. 2016 were chosen as the research subjects, who were randomly divided into observation group and control group(106 cases in each group).Conventional treatment with antibiotics and atomization inhalation was given to both groups, and observation group was also given venous dripping of Xiyanping injection. The treatment lasted for 7 days.The improvement in the following aspects were observed in the two groups: clinical effect, fever-relief time, cough-relief time, time for pulmonary signs to disappear, hospitalization time, C-reactive protein, erythrocyte sedimentation rate(ESR),white blood cell count and lung function(tidal expiratory peak velocity).
Results
The clinical total effective rate in observation group was 94.3%(100/106),which was significantly higher than that in control group(76.4%,81/106)(P<0.05).After 5 days of treatment, the positive rate of sputum culture in observation group was 7.3%(15/106),significantly lower than that in control group(28.3%,30/106)(P<0.05).The fever-relief time and cough-relief time, the time for pulmonary signs to disappear and the length of hospital stay were all significantly shorter in observation group than in control group(P<0.05). The Creactive protein, erythrocyte sedimentation rate and WBC counts in observation group were lower than those in control group after treatment, while the tidal expiratory peak velocity was higher, the difference being statistically  significantly(P<0.05).
ConclusionXiyanping injection has good effect in the treatment of bacterial lower respiratory tract infection in children.

Key words: Lower respiratory tract infection, Bacterial, Xiyanping, Child