ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (5): 432-434.doi: 10.3969/j.issn.1674-3865.2017.05.022

• 临床研究 • 上一篇    下一篇

重组人表皮生长因子治疗小儿疱疹性口龈炎疗效观察

刘芙蓉，罗如平   

  1. 410007 长沙，湖南省儿童医院感染科
  • 出版日期:2017-10-25 发布日期:2017-12-18
  • 通讯作者: 刘芙蓉，E-mail：564549384@qq.com
  • 作者简介:刘芙蓉（1982-），女，医学硕士，主治医师。研究方向：儿童感染性疾病的诊治

Observation on the effects of recombinant human epidermal growth factor in treatment of infantile herpetic gingivitis

LIU Furong，LUO Ruping   

  1. Department of Infectious Diseases, Hunan Children's Hospital, Changsha 410007, China
  • Online:2017-10-25 Published:2017-12-18

PDF (PC)

124

摘要：
目的
观察重组人表皮生长因子治疗小儿疱疹性口龈炎的临床效果。
方法
2014年3月至2016年9月湖南省儿童医院感染科收治住院的疱疹性口龈炎患儿60例，随机分为对照组和观察组各30例。对照组给予单磷酸阿糖腺苷抗病毒治疗，观察组在对照组治疗基础上加用重组人表皮生长因子——金因肽喷雾剂直接喷在口腔、牙龈等患处。两组均治疗7 d，比较两组临床疗效及牙龈红肿消退时间，开始进食时间，溃疡、疱疹愈合时间。
结果
观察组总有效率为93.3%（28/30），显著高于对照,73.3%（22/30），差异有统计学意义（P<0.05）。观察组在牙龈红肿消退时间，开始进食时间，溃疡、疱疹愈合时间方面均少于对照组，差异有统计学意义(P<0.05)。
结论
单磷酸阿糖腺苷联合重组人表皮生长因子治疗小儿疱疹性口龈炎效果优于单用单磷酸阿糖腺苷，药物毒副作用少、易于患儿接受，值得临床应用推广。

关键词: 疱疹性口龈炎, 重组人表皮生长因子, 儿童

Abstract:
Objective
To observe the clinical effect of recombinant human epidermal growth factor in the treatment of children with herpetic gingivitis.
Methods
Totally 60 children with herpetic gingivitis treated in Hunan Children's Hospital from Mar. 2014 to Sep. 2016 were randomly divided into two groups: 30 in control group and 30 in observation group. Both groups were given antivirus treatment with adenosine monophosphate, and the observation group was also given recombinant human epidermal growth factor——Jinyintai spray, which was sprayed in the oral cavity and on gingiva. The treatment lasted for 7 days. Compare the clinical effect, the time of recession of gum swelling and beginning to eat, and the healing time of ulcer and herpes.
Results
The total effective rate of observation group was 93.3%(28/30), significantly higher than that of control group(73.3%,22/30), and there was statistical difference(P<0.05). All the above-mentioned time was shorter in the observation group, and the difference was statistical(P<0.05).
Conclusion
Adenosine monophoshate combined with recombinant human epidermal growth factor is better than adenosine monophosphate alone in the treatment of children with herpetic gingivitis, and there is fewer adverse reactions, which is easy for children to accept and worthy of clinical application.

Key words: Herpetic gingivitis, Recombinant human epidermal growth factor, Children