ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (5): 399-401.

• 临床研究 • 上一篇    下一篇

β2-微球蛋白与中性粒细胞明胶酶相关脂质运载蛋白联合检测在传染性单核细胞增多症 患儿早期肾损伤的价值分析

目的：探究β2-微球蛋白与中性粒细胞明胶酶相关脂质运载蛋白（NGAL）联合检测对传染性单核细胞增多症患儿早期肾损伤的诊断价值分析。
方法：选取我院2016年1月至2019年10月收治住院的传染性单核细胞增多症患儿85例，根据是否有肾损伤分为肾损伤组42例和无肾损伤组43例，同期选取我院健康体检儿童40例为健康对照组。对比尿液β2微球蛋白、NGAL、微量白蛋白/肌酐、N-α-乙酰基-β-D氨基葡萄糖苷酶(NAG)水平。
结果：肾损伤组β2-微球蛋白、NGAL、微量白蛋白/肌酐、NAG水平及阳性率均高于无肾损伤组和健康对照组，差异均有统计学意义（P<0.05）；无肾损伤组和健康对照组对比差异均无统计学意义（P>0.05）。
结论:β2-微球蛋白、NGAL、微量白蛋白/肌酐、NAG四项联合检测可有效诊断传染性单核细胞增多症患儿早期肾损伤，标本来源容易、操作简单，利于推广。   

  1. 456750 河南 鹤壁，河南省淇县人民医院检验科（牛震丙，刘静）；475000 河南 开封，开封市肿瘤医院检验科（冯利利）
  • 出版日期:2021-10-25 发布日期:2021-11-18
  • 通讯作者: 牛震丙，E-mail：qxnzbyx@163.com
  • 作者简介:牛震丙（1989-）,女，主管检验师。研究方向：医学检验

Value of the combination detection of β2-microglobulin and neutrophil gelatinase-associated lipocalin in early renal injury in children with infectious mononucleosis

Objective:To study the value of combination detection of β2-microglobulin and neutrophil gelatinase-associated lipocalin(NGAL) in the diagnosis of early renal injury in children with infectious mononucleosis (IM).#br# Methods:Totally 85 children with IM were chosen, who were hospitalized for treatment from Jan. 2016 to Oct. 2019. They were divided into renal injury group(42 children，group A) and no-renal-injury group(43 children, group B). Forty healthy children receiving physical examination in our hospital in the same period were included as the healthy control group(group C). Compare the levels of urinary β2-microglobulin, NGAL, microalbumin/creatinine and NAG.#br# Results:The level of β2-microglobulin, NGAL, microalbumin/creatinine and NAG and the positive rate in group A were all higher than those in group B and group C, and the difference was statistically significant(P<0.05). There was no statistical difference between group B and group C(P<0.05).#br# Conclusion:The combination detection of β2-microglobulin, NGAL, microalbumin/creatinine and NAG is effective in the diagnosis of early renal injury in children with infectious mononucleosis. The samples are easy to obtain and the operation is simple, which helps to promote the method.   

  1. Testing Department of Qixian County People's Hospital of Henan Province, Hebi 456750, China
  • Online:2021-10-25 Published:2021-11-18

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摘要： 目的：探究β2-微球蛋白与中性粒细胞明胶酶相关脂质运载蛋白（NGAL）联合检测对传染性单核细胞增多症患儿早期肾损伤的诊断价值分析。
方法：选取我院2016年1月至2019年10月收治住院的传染性单核细胞增多症患儿85例，根据是否有肾损伤分为肾损伤组42例和无肾损伤组43例，同期选取我院健康体检儿童40例为健康对照组。对比尿液β2微球蛋白、NGAL、微量白蛋白/肌酐、N-α-乙酰基-β-D氨基葡萄糖苷酶(NAG)水平。
结果：肾损伤组β2-微球蛋白、NGAL、微量白蛋白/肌酐、NAG水平及阳性率均高于无肾损伤组和健康对照组，差异均有统计学意义（P<0.05）；无肾损伤组和健康对照组对比差异均无统计学意义（P>0.05）。
结论:β2-微球蛋白、NGAL、微量白蛋白/肌酐、NAG四项联合检测可有效诊断传染性单核细胞增多症患儿早期肾损伤，标本来源容易、操作简单，利于推广。

关键词: 传染性单核细胞增多症, 早期肾损伤, β2-微球蛋白, 儿童

Abstract: Objective:To study the value of combination detection of β2-microglobulin and neutrophil gelatinase-associated lipocalin(NGAL) in the diagnosis of early renal injury in children with infectious mononucleosis (IM).
Methods:Totally 85 children with IM were chosen, who were hospitalized for treatment from Jan. 2016 to Oct. 2019. They were divided into renal injury group(42 children，group A) and no-renal-injury group(43 children, group B). Forty healthy children receiving physical examination in our hospital in the same period were included as the healthy control group(group C). Compare the levels of urinary β2-microglobulin, NGAL, microalbumin/creatinine and NAG.
Results:The level of β2-microglobulin, NGAL, microalbumin/creatinine and NAG and the positive rate in group A were all higher than those in group B and group C, and the difference was statistically significant(P<0.05). There was no statistical difference between group B and group C(P<0.05).
Conclusion:The combination detection of β2-microglobulin, NGAL, microalbumin/creatinine and NAG is effective in the diagnosis of early renal injury in children with infectious mononucleosis. The samples are easy to obtain and the operation is simple, which helps to promote the method.

Key words: Infectious monondeosis, Early renal injury, β2-microglobulin, Child